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Xeljanz Cancer Risks Detailed

d MedPage Today

The degree to which the oral rheumatology drug tofacitinib (Xeljanz) seems to promote new malignancies is now fleshed out in the latest, and at least somewhat reassuring, report from a landmark safety study.

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Bimekizumab Efficacy in TNF-Refractory Psoriatic Arthritis

d Jack Cush, MD

Bimekizumab, a selective inhibitor of interleukin (IL)-17F and IL-17, has shown superior efficacy and safety in a 16 week trial in patients with active psoriatic arthritis who previously failed therapy with tumour necrosis factor-α (TNFi) inhibitors.

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The Top 10 Research Priorities in Psoriatic Arthritis

d Jack Cush, MD

A survey of 317 carers and clinicians focused on psoriatic arthritis has set an agenda of the top 10 research questions for psoriatic arthritis (PsA).

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Multi-ancestry analysis reveals novel genetic loci associated with Osteoarthritis

d Jack Cush, MD

The first large multi-ancestry genetics study of osteoarthritis (OA) has found 10 novel OA-associated genetic loci, and results showed some of the OA-associated regions are robustly found in every population ancestry studied. 

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GCA: What we feel and what we can't Dr. David Liew ( @drdavidliew) discusses Abstracts 0483 and 0486 at #ACR22 Convergence. https://t.co/Pobsb2anLa https://t.co/RQS4N3TqgK

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Timely Fetal Screening Important in Positive Anti-Ro Antibody Pregnancies Dr. Yusof ( @Yuz6Yusof) discusses Abstract 0957 presented at #ACR22. https://t.co/yl4K7jZMGr https://t.co/6733AEhRyX

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Imaging in PMR One of the major limitations of PMR management is the lack of a gold standard investigation or biomarker of disease activity. https://t.co/sZtgWKAtFv https://t.co/4H4tAY6CIZ

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Why treatment of pre-RA isn't ready for prime time The ACR Great Debate was on "To treat or not to treat in pre-RA?" and it was stressed that autoimmunity may start well before clinical symptoms occur. https://t.co/A0dx3PFyiJ https://t.co/wqBuM8XD7M

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Familial Mediterranean Fever mimics Dr Baspinar et al. performed a large case-control study in Turkey to assess whether acute abdomen episodes which led to appendectomies could be misdiagnosed as appendicitis rather than FMF-associated serositis.#ACR22 https… https://t.co/fHgeoLjNOu
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Hydroxychloroquine: Cumulative Doses and Thresholds Dr. Sheila Reyes ( @RHEUMarampa) discusses Abstracts 0982 and 0344 at #ACR22 Convergence. https://t.co/k33LUNnTmV https://t.co/AJSBdT4rJC

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Spondyloarthritis: Novel Therapies, Diagnostic Dilemmas and Depression Dr. Lianne Gensler ( @lianegensler discusses the following abstracts presented at #ACR22. Abstracts 1597, 1598, 1599 (treatment) and 1613, 1609 and 1614 (diagnosis and outcomes) https://t.co/0wCxKyFM0u https://t.co/8vaZ1ZncjF

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Comorbidities in Ankylosing Spondylitis Dr. Akhil Sood ( @AkhilSoodMD) discusses Abstract 1609 at #ACR22 Convergence. https://t.co/tX0gP3mYmW https://t.co/PYLpoczz08

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Vaccines Work! Dr. Eric Dein ( @ericdeinmd) and Dr. Caoilfhionn Connolly discuss abstracts 2275 & 0797 at #ACR22 Convergence. https://t.co/xXcs5yQPSi https://t.co/1C4Cj9Ykei

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Systematic review of MSK findings in patients with acute lymphoblastic leukemia finds 29 pts with peripheral arthritis (7), axial manifestations (17), and osteolytic lesions (21 pts) & Vertebral Fx (4) Hypercalcemia in 9 cases. https://t.co/DhCMMlMs7f https://t.co/HjjL4aF22a

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Comparison of 227 Systemic Sclerosis pts w/ & without ILD shows SSc-ILD to have more muscle Dz [OR 2.55], LVDD [OR 2.36], PAH [OR 9.13], dcSSc [OR 2.86], PLR [OR 1.005], elevated KL-6 [OR 2.03], and anti-Scl-70 [OR 3.1]. https://t.co/Pzx9N5rPcF https://t.co/F8mBQ1u5iL

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Fat and bone are never alone: osteoporotic fracture in RA Dr. David Liew ( @drdavidliew) discusses Abstract 889 at #ACR22. Abstract 889: Serum Adipokines Predict Incident Osteoporotic Fracture in Patients with Rheumatoid Arthritis https://t.co/jSFmOiQb6N https://t.co/JTXugoxofP

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Gender Differences in axSpA In abstract 1614, Dr. Poddubnyy presents the results of the PROOF study which assessed the probability of achieving inactive disease or low disease activity among males and females who were recently diagnosed with axSpA. https://t.co/DL2TDgXJnG https://t.co/XSQxWWnQgD

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Lupus Linked With Greater Risk of Cardiovascular Complications of Childbirth Pregnant women with SLE were more prone to cardiovascular complications during delivery, and their risk seems to have increased over the past 15 years, according to data. https://t.co/mRUOVrKbt2 https://t.co/m18DWxSV20

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Retrospective study of US National Inpatient Sample data 2015-2019 looked at 60,360 gout admissions, roughly 1/4 had Arrhythmias (mostly older pts; AFib (88%), atr flutter (6.2%), VTach (3.2%). Gout-arrhythmia pts had more deaths (adj OR 2.06) https://t.co/L1WEsybI7h https://t.co/xwAfFVJOuk

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In pts undergoing hip or knee arthroplasty for OA, aspirin (3.45%) compared with enoxaparin (1.82%) resulted in a significantly higher rate of symptomatic VTE within 90 days, defined as below- or above-knee DVT or pulmonary embolism https://t.co/7hgLbynNx6 https://t.co/HMc4UbMcdy

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