Knee OA (not Hand) is Associated with Higher Mortality in Women

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"Doc....the pain is killing me."

This oft heard patient complaint may be truer than you think.

Increasing Risk of Septic Arthritis with Age

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A retrospective population-based study from New Zealand examined the epidemiology, clinical features, and microbiology of adult native joint septic arthritis.

Vertebral Fractures in 10% of Spondyloarthritis Patients

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Vertebral fractures are not uncommon in patients with ankylosing spondylitis and spondyloarthritis.

Physical Therapy Has Modest Effects on Acute Low Back Pain

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A new JAMA study shows new onset back pain treated with physical therapy yields modest short-term (3 months) improvement. 

Prescription Opioid Use Falls While Abuse Rises

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From 2003 to 2013, the percentage of nonmedical use of prescription opioids decreased among adults in the U.S., while the prevalence of prescription opioid use disorders, frequency of use, and related deaths increased, according to a study in the October 13 issue of JAMA.

Circadian Efficacy with Cathepsin K Inhibitor ONO-5334

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Osteoporosis is associated with significant morbidity, and hip fractures as sequelae confer a 1-year mortality risk of 8.4–36%.

Increasing Numbers of Knee Replacements

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Knee replacement surgery is on the rise, and so is the cost.

Prolonged Breastfeeding Associated with Postmenopausal Osteoporosis

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The effects of prior breastfeeding on bone density of postmenopausal women have been controversial. Several studies suggest that breastfeeding and childbirth lead to maternal calcium loss and a decline in bone mineral density (BMD).

A Controlled Trial of Yoga Benefits Arthritis Patients

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Yoga and stretching appear to be important forms of exercise for patients with fibromyalgia, but their utility has seldom been explored in patients with rheumatoid or osteoarthritis.

Age and Comorbidity Contribute to Higher Death Risk Following Hip Fracture Surgery

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Patients undergoing surgery for a hip fracture appear to have higher death rates than those having elective total hip replacement.

Overuse and Underuse of Osteoporosis Drugs

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A population-based sudy 824 post-menopausal women ≥50 years old from Valencia, Spain was studied to estimate the percentage of women eligible for treatment, and the proportion of overuse and underuse of antiosteoporotic treatment according to highly-influentia

A Rule of Five Spots Spine Disease

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A combined rule of five -- the presence of at least five fatty lesions/erosions in the sacroiliac (SI) joint, at least five fatty lesions in the spine, or at least five spinal inflammatory lesions on magnetic resonance imaging (MRI) -- is highly specific for axial spondyloarthritis in patients wi

Romosozumab Surpasses Teraparitide in the STRUCTURE Study

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The experimental bone drug, romosozumab, has succeeded in meeting its primary endpoint by showing it was significantly more effective than teriparatide in a 12-month study assessing total hip bone density in postmenopausal women with osteoporosis.  

Bicycle Injuries and Fatalities Increasing in Older Americans

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JAMA reports the number of traumatic injuries related to bikes in adults nearly doubled from 1998 to 2013 -- going from 8,791 to 15,427. The researchers used data from the National Electronic Injury Surveillance System, which includes data from of 100 emergency departments, and U.S.

MOST Study: End Stage Knee Osteoarthritis Shows Dynamic Change by MRI

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Guermazi and colleagues have investigated whether end-stage knee osteoarthritis (OA), assessed as grade 4 Kellgren and Lawrence (KL) radiographic changes, are really "end stage".   

Growth Hormone Protects Against Osteoporotic Fractures

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In a decade-long study of the effects of growth hormone (GH), 80 women with osteoporosis on HRT, between ages of 50-70 yrs were randomized to receive GH 1.0 U or GH 2.5 U recombinant human GH or placebo sc daily during 3 years and compared to an age-matched populatoin sample of (n=120).

BMI at Age 20 Influences Future Risk of Low Back Pain

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A nationwide, cross-sectional study of men aged 30–50 years (n=1385) examined the relationship between weight and back pain over time.

"Eye of Newt" Leads Regenerative Therapy in Osteoarthritis

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Regeneration of cartilage is the holy grail of osteoarthritis research.

Osteoarthritis Update August 2015

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Different Phenotypes for Osteoarthritis of the Foot. Osteoarthritis is often characterized as either a symmetric polyarticular (often involving DIPs, PIPs and CMC1), asymmetric oligoarticular or monarticular (knee or hip OA), but OA may also affect the foot.