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Low Dose IL-2 Therapy in Sjögren’s

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d Jack Cush, MD

Nov 29, 2022

There is a large, unmet need in treating Sjögren’s syndrome, yet a new randomized clinical trial has shown that low-dose interleukin 2 (LD-IL-2) was effective effective and well tolerated in patients with primary Sjögren’s syndrome (pSS), with evidence of restored immune balance.

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ACR meeting education

ACR22 Takeaways: Pre-RA, Lupus, PsA and AS

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d Robert Chao, MD

Nov 29, 2022

ACR22 Convergence left us bountiful with information from all over the world. Here are a few of my personal highlights and key takeaways.

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lupus SLE

Tyk2 Inhibition Effective in SLE

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d Jack Cush, MD

Nov 28, 2022

Deucravacitinib, an oral, selective TYK2 inhibitor, has demonstrated efficacy in a phase II trial active systemic lupus erythematosus (SLE) patients.

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How Underweight Women Can Reduce Hip Fracture Risk

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d EurekAlert!

Nov 28, 2022

How women can reduce the risk of hip fracture?

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Cancer Screening Recommendations in Idiopathic Inflammatory Myopathy

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d Rachel Tate, DO

Nov 28, 2022

Idiopathic inflammatory myopathy (IIM) is associated with increased risk of lung, ovarian, colorectal, lymphoma, breast, and naso-pharyngeal cancers, often within three years of disease onset. At ACR22, plenary abstract 0002, Oldroyd, et al, reviewed the 18 recommendations provided by the International Myositis Assessment and Clinical Studies Group (IMACS) steering committee.

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Treatment Persistence and Switching Patterns of an Adalimumab Biosimilar Dr. Julian Segan ( @JulianSegan) discusses Abstract 1425 at #ACR22 Abstract 1425: Treatment Persistence and Switching Patterns of AMGEVITA® in German Patients with RD https://t.co/MpNnrqYxGJ https://t.co/Sfi1kxOXLX

Links:

https://bit.ly/3GWpXga

Dr. John Cush RheumNow ( View Tweet)

Nov 29, 2022

Fat and bone are never alone: osteoporotic fracture in RA Dr. David Liew discusses Abstract 889 at #ACR22. Abstract 889: Serum Adipokines Predict Incident Osteoporotic Fracture in Patients with Rheumatoid Arthritis https://t.co/4IrdQBq1z2 https://t.co/2HySVG1SGY

Links:

https://bit.ly/3UhZVGU

Dr. John Cush RheumNow ( View Tweet)

Nov 29, 2022

Topic Podcasts #ACR22 - SpA Part3 -Opioids and Health Care Utilization in PsA and AS -Reproductive health in a post-Roe world -SpA: Novel Therapies, Diagnostic Dilemmas and Depression -Tapering TNFi in nonradiographic AxSpA and more https://t.co/hXPlQaxPWs https://t.co/2SRYS6EOr7

Links:

https://bit.ly/3VjQc4g

Dr. John Cush RheumNow ( View Tweet)

Nov 29, 2022

How Underweight Women Can Reduce Hip Fracture Risk https://t.co/Czf3YJbD2r https://t.co/xKaZPTTOcS

Links:

https://bit.ly/3VFRO8t

Dr. John Cush RheumNow ( View Tweet)

Nov 29, 2022

Tyk2 Inhibition Effective in SLE Deucravacitinib, an oral, selective TYK2 inhibitor, has demonstrated efficacy in a phase II trial active systemic lupus erythematosus (SLE) patients. https://t.co/cpbDnkfUIS https://t.co/xct8dACBAY

Links:

https://bit.ly/3XKtP9K

Dr. John Cush RheumNow ( View Tweet)

Nov 29, 2022

RCT data on BTK inhibitor evobrutinib shows it to be well tolerated. Ph 2 RCT data on 1083 pts (RA, MS, SLE) Rx w/ evobrutinib(861) or placebo(271) for ~ 6 mos. No diff in TEAEs or EAIR , 2 deaths (SLE), SIE 2-3/100PY https://t.co/4HOTKuCAUi https://t.co/u7KSD6RN4q

Links:

https://bit.ly/3ubpXB8

Dr. John Cush RheumNow ( View Tweet)

Nov 29, 2022

Study of 294 SLE pts on HCQ (2005-2021): 37 (13%) developed CHF w/ low EF (HFrEF), arrhythmia or cardiac death. After adjustments, wt-based dosing of HCQ not assoc w/ cardiac events(sHR 0.62; 0.41,0.92) & may decrease risk in non-smokers https://t.co/ufYcnuMI2r https://t.co/cOPIUpwpHf

Links:

https://bit.ly/3AS3qNv

Dr. John Cush RheumNow ( View Tweet)

Nov 29, 2022

JAMA - Update/Review of Hemochromatosis Dx and Rx. - 5 gene defects in hepcidin. 95% HFE & the C282Y variant - 90%are asymptomatic - Suspicion w/ arthralgias, LFTs, hepatomegaly, cardiomyopathy, 1st degr relative - Untreated, 9% risk of cirrhosis https://t.co/nuq8Ioralk https://t.co/djwlVsIk3b

Links:

https://bit.ly/3EDapuS

Dr. John Cush RheumNow ( View Tweet)

Nov 29, 2022

#ACR22 - SpA Part2 -Comorbidities in Ankylosing Spondylitis -Early Diagnosis of AxSpA -Fertility issues in SpA -Gender in AxSpa -Inadequate Dosing of HCQ Leads to Hospitalizations in SLE -JAK inhibitors in RD -Opioid use in PsA and SpA https://t.co/1xJzSmekR2 https://t.co/kxpLGi8Ky4

Links:

https://bit.ly/3Vv0Ftq

Dr. John Cush RheumNow ( View Tweet)

Nov 29, 2022

#ACR22- SpA Part1 -AI Future of Sacroiliitis Assessment AI in Detecting Sacroiliitis -AxSpA: gender differences -Can we alter neonatal gut microbiome to prevent SpA? -Comorbidities in AxSpA -Do Disease Activity Measures Really Capture AS in Women? https://t.co/sFIZz7pKSF https://t.co/CAh5TZ4FEX

Links:

https://bit.ly/3ieffXX

Dr. John Cush RheumNow ( View Tweet)

Nov 28, 2022

PreRA to Treat or Not! Dr. Janet Pope ( @Janetbirdope ) weighs in. #ACR22 https://t.co/778jWLizeW https://t.co/ZHIQTuYyyg

Links:

https://bit.ly/3GTP1Eq

Dr. John Cush RheumNow ( View Tweet)

Nov 28, 2022

Prescribing Methotrexate in Post-Roe Era Dr. Cassy Sims ( @DrCassySims) reports live from #ACR22. L09: Impact on Access to Methotrexate in the Post-Roe Era https://t.co/GwgSqBj5EX https://t.co/WzFGnJyIf3

Links:

https://bit.ly/3gBsrWB

Dr. John Cush RheumNow ( View Tweet)

Nov 28, 2022

Is exercise the missing medicine in lupus? Sarah Patterson, MD from UCSF will present oral abstract #2225 entitled “Physical Inactivity is Associated with Increased Expression of T cell inflammatory genes in Systemic Lupus.” https://t.co/LomZ8U8pzj https://t.co/PEZHypeasB

Links:

https://bit.ly/3Ud6VF6

Dr. John Cush RheumNow ( View Tweet)

Nov 28, 2022

To Switch or Not: Biosimilars in Inflammatory Arthritis Dr. Jonathan Kay reports on abstract 1112 at #ACR22 Convergence. https://t.co/nrsH7yB7wu https://t.co/TngS4Kk6YK

Links:

https://bit.ly/3Vwff42

Dr. John Cush RheumNow ( View Tweet)

Nov 28, 2022

Artificial Intelligence in Detecting Sacroiliitis Dr. Akhil Sood ( @AkhilSoodMD) discusses Abstract 0383 at #ACR22. https://t.co/U52eAFOePr https://t.co/8WcecoF5Sr

Links:

https://bit.ly/3gCcIqd

Dr. John Cush RheumNow ( View Tweet)

Nov 28, 2022

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