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RheumNow Podcast – Tofacitinib Safety Concerns (2.5.2021)

Jack Cush, MD

Dr. Jack Cush reviews and discusses the news and journal reports from the past week on RheumNow.com.

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Hydroxychloroquine Fails to Prevent COVID-19

Jack Cush, MD

There is a preponderance and mounting evidence that hydroxychloroquine is ineffective in COVID-19 infection; and now the NEJM reports a the results of a trial where HCQ given as post-COVID exposure therapy failed to prevent SARS-CoV-2 infection or symptomatic Covid-19 in healthy persons.

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Adverse Events with Anti-malarials during the COVID Pandemic

Jack Cush, MD

For a variety of reasons, the use of anti-malarials (chloroquine and hydroxychloroquine) rose dramatically in the pandemic; notable was the lack of proven benefit and the dramatic risk in reported adverse drug reactions (ADRs) associated with these drugs being used to treat SARS-CoV-2.

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RheumNow Podcast – Rheumatology Burnout (1.29.2021)

Jack Cush, MD

Dr. Jack Cush reviews this past week's journal articles and news features on RheumNow.com. Colchicine, vaccine rollout, risk of RA in endometriosis patients, tREACH trial, lupus nephritis news, rheumatology burnout and more.

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Protective Effects of Colchicine in Non-Hospitalized COVID-19

Jack Cush, MD

A press release from Montreal Heart Institute announced that the COLCORONA clinical trial provided evidence of the protective effect of colchicine; demonstrating a 21% reduced risk of death or hospitalizations in patients with COVID-19 compared to placebo. COLCORONA trial was a contact-less, randomized, double-blind, placebo-controlled study of 4,488 non-hospitalized patients from Canada, the U.S., Europe, South America and South Africa.

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OpenSAFELY analysis shows that NSAIDs safe w/ COVID. Study 1: 1/2 million NSAID users vs ~2 mill non-users found no difference in COVID-19 death (HR 0.96); Study 2: 1.7 million RA/OA pts, 10% on NSAIDs had a lower risk of COVID-19 death (HR 0.78) https://t.co/1f3JBmaf2e

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Dr. John Cush RheumNow ( View Tweet)

Adverse Events with Anti-malarials during the COVID Pandemic Despite very preliminary mixed results, the endorsement of chloroquine and hydroxychloroquine use to treat COVID-19 led substantial use (and drug shortages) for these drugs. https://t.co/UQYo3a8ZKI

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Dr. John Cush RheumNow ( View Tweet)

Don’t Hold the Benlysta, Take the Vaccine The RheumNow podcast is available on Soundcloud, https://t.co/fxtCOkxTER, and Apple/Android car play. https://t.co/34XMLMZGMH

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Dr. John Cush RheumNow ( View Tweet)

QD Clinic Podcast for the week of Jan 29 - Pearls from Practice This wk: Arthritis &Crohn's Rhabdo or Not Dadgummit, Where's Waldos COVID Vaccine? "I Don't Know" A Tale of Two Gouts https://t.co/7ndYSOgh5R or listen on iTunes https://t.co/FHJv01AAbC https://t.co/780P7Bdw8F

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Dr. John Cush RheumNow ( View Tweet)
RheumNow Podcast is up - Rheumatology Burnout (1.29.2021) - Vaccine #s, Colchicine in COVID, Rheums #2 in Burnout? Endometriosis & RA risk, Comorbidity as predictors. https://t.co/HiX7qMFU6b or listen on iTunes>>https://t.co/FHJv01AAbC or on SoundCloud>> https://t.co/0BfqGhxgQj https://t.co/j9nHMs4C6d

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Dr. John Cush RheumNow ( View Tweet)
My #rheumatology clinics now inundated with patient questions re: #CovidVaccine. I'm looking forward to new #CovidVaccine Guidance expected from the newly-convened #ACR Task Force, forthcoming on February 11th.

Jeffrey Curtis RADoctor ( View Tweet)

QD Clinic - Dadgummit, Where's Waldo's COVID Vaccine? My rant on the COVID vaccine unavailability, and what we can - and can't - tell patients. https://t.co/VKrDgvuXqt https://t.co/zuNe8lEaR4

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Dr. John Cush RheumNow ( View Tweet)
Vaccine Rollout: Fed has delivered about 44.4 million Vax doses to states (~24 mill doses given). Estimated 6% (19.9 mill) have had one vax dose and 1% (3.5 mill) 2 doses. 2.7 of 3 million elderly in nursing homes long-term-care have recv >= 1 vax dose .https://t.co/HaoIRP4Uoo

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Dr. John Cush RheumNow ( View Tweet)

RheumNow COVID-19 Updates https://t.co/TiB7739ONL

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Dr. John Cush RheumNow ( View Tweet)

Protective Effects of Colchicine in Non-Hospitalized COVID-19 A press release from the Montreal Heart Institute has announced that the COLCORONA clinical trial has provided evidence of the protective effect of colchicine. Read more: https://t.co/quo19EPJUQ https://t.co/B65RGButgm

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Dr. John Cush RheumNow ( View Tweet)
After you receive the 2nd dose of the COVID vaccine, note that it takes 2 weeks after the second dose to achieve high antibody levels against COVID-19, underscoring the importance of continuing masking, physical distancing and hand hygiene https://t.co/ZsWIM9O3Iu
Dr. John Cush RheumNow ( View Tweet)
NEJM: Early Combo Monoclonal Antibody Therapy in COVID-19 NEJM has published the interim analysis of the REGN-COV2 trial, wherein an antibody cocktail reduced viral loads with less clinical consequences. https://t.co/Gdby5qmPNG

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Dr. John Cush RheumNow ( View Tweet)

Combo Anti-Spike Protein Antibody for Mild to Moderate COVID-19 https://t.co/DuG7pI4jL9

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Dr. John Cush RheumNow ( View Tweet)

Don’t Hold the Benlysta, Take the Vaccine https://t.co/yBWj2U4ZnZ

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Dr. John Cush RheumNow ( View Tweet)

2 very large UK population studies (millions of pts) show there is no evidence that NSAID use yields harm in those infected with COVID related deaths. There is either no risk (HR 0.96; 0.80, 1.14) or a reduced risk (HR 0.78; 0.64, 0.94) in these studies. https://t.co/gazA83Ogis

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Dr. John Cush RheumNow ( View Tweet)

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