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Hypertension Unaffected by Urate Lowering Therapy

Jack Cush, MD

Does uric acid contribute to the risk of hypertension (HTN)?  A recent cohort trial shows that allopurinol in young adults does not sufficiently lower blood pressure (BP).

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Serious Infections Still Common in Vasculitis

MedPage Today

Serious infections occurred more frequently among patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis who were given induction therapy with cyclophosphamide compared with rituximab (Rituxan), Greek researchers found.

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RheumNow Podcast – Infection in ANCA-Associated Vasculitis (3.26.2021)

Jack Cush, MD

Dr. Jack Cush reviews the news, FDA Denials and journal articles from the past week on RheumNow.com.

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RECIPE Trial - Mycophenolate to Suppress Immunogenicity with Pegloticase in Gout

Jack Cush, MD

Pegloticase is indicated in the treatment of severe gout patients but prolonged use may be limited by immunogenicity to the PEG moiety. A randomized, controlled trial has shown that concomitant mycophenolate mofetil (MMF) may prolong the efficacy of pegloticase in gout.

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MDA-5 Antibodies and Juvenile Dermatomyositis

Jack Cush, MD

A multicentre, retrospective study examined MSA profiles (by immunoprecipitation) from 96 juvenile idiopathic inflammatory myopathies (JIIM) at nine pediatric rheumatology centres in Japan. MSA were found in 85 of 96 cases with over 90% of patients having one of the following three MSA

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COVID-19-Related Deaths in Rheumatic Disease Patients

Jack Cush, MD

There is a growing body of evidence regarding COVID-19 outcomes (including death) in rheumatic disease patients; analysis of a German registry shows that poor control, rituximab, sulfasalazine and other immunosuppressives could be risk factors for COVID-related death.

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RheumNow Podcast – Sweet Lies or Hard Truths? (2.26.2021)

Jack Cush, MD

Dr. Jack Cush reviews and discusses the news and Journal reports from the past week on RheumNow.com.

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Great #RNL2021 coverage from @uptoTate #RheumNow Not all that is pink and scaly is Psoriasis! DDx can include Sezary, Granuloma Annulare, Pemphigus, Erythroderma, paraneoplasm, eczema, lichen, basal cell CA, AKs, allergens, etc. Melodie Young, NP

Dr. John Cush RheumNow ( View Tweet)

Have you listened to last week's podcast? It's available wherever podcasts are available. Upadacitinib Wins in PsA https://t.co/Pd7QG6SsmJ https://t.co/3onAtZyoTt

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Dr. John Cush RheumNow ( View Tweet)
From @KDAO2011-- "Is it better to taper the steroids or leave it? SEMIRA study. Tapering off low dose steroids cause more flares and more treatment side effects. Dr. Buttgereit says keep your low dose steroids (prednisone 5 mg/day or less) https://t.co/RAYkVxGO9N #RNL2021"

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Dr. John Cush RheumNow ( View Tweet)

Beijing study of 207 RA patients starting DMARD and steroids (GC) shows after 3 years only 59% D/C GC (mean was 24 mos). Odds of stopping GC were 10% @ 6mos, 27% @Yr1, 48% @Yr 2 and 59% at 3 years. https://t.co/E2RchB9IAs https://t.co/uDEAqaM8GC

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Dr. John Cush RheumNow ( View Tweet)
From @KDAO2011 for #RNL2021 Is it better to taper the steroids or leave it? SEMIRA study. Tapering off low dose steroids cause more flares and more treatment side effects. Dr. Buttgereit says keep your low dose steroids (prednisone 5 mg/day or less) https://t.co/FpQnxUKWwF

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Dr. John Cush RheumNow ( View Tweet)

“Give as much glucocorticoids as necessary but as little as possible!” – Dr. F Buttgereit #RNL2021 #RheumNow Original tweet from Dr. Kathryn Dao @KDAO2011

Dr. John Cush RheumNow ( View Tweet)

Potent Topical Corticosteroids and the Risk of Osteoporotic Fractures https://t.co/OHohMKveik

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Dr. John Cush RheumNow ( View Tweet)

UTSW Rheum Gran Rounds - Dr. Ken Saag, Anakinra vs IA steroids @UTSWIMchief @KenSaag https://t.co/M2UCbyuJpb
Dr. John Cush RheumNow ( View Tweet)
Early RA pts given steroids (GC) do Not have short or long term benefits from GCs. 180 ERA pts given compared to 294 who did not. 5 yr F/U showed no differences in DAS28-CRP, HAQ or pain between groups. Steroids were used more in seronegative RA. https://t.co/CDUKDgsLRa

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Dr. John Cush RheumNow ( View Tweet)

News Feature: Potent Topical Corticosteroids and the Risk of Osteoporotic Fractures https://t.co/KazNPRXKNx https://t.co/pykBdbexzF

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Dr. John Cush RheumNow ( View Tweet)
@RheumNow #RNL2021 Dr. Buttgereit on steroids in RA: 2.5 mg/d of prednisone increase total steroid amount in the body by 100% - great therapeutic effect but comes w/plethora of side effects. Q: how do you feel out long term low dose steroids for RA?

Olga Petryna DrPetryna ( View Tweet)

Cohort analysis of 12351 RA patients from CPRD registry - finds RA on both glucorticoids & PPI have a greater risk OP fractures (adj HR: 1.60, 95% CI: 1.35 to 1.89) vs non-use. Higher than the Fx Risk with either oral GC or PPI use alone (adj HR 1.2). https://t.co/oPMnJoHCjX https://t.co/eW7rpVeHa4

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Dr. John Cush RheumNow ( View Tweet)
Analysis of incident #RA in UK Clinical Practice registry shows recent prednisone >=7.5mg/d is assoc w/ hypertension in RA. In 17760 RA pts, 42% were Rx steroids; recent GC yielded a 17% increase in HTN (HR 1.17); only >7.5mg/D implicated https://t.co/qUKs2oZZUV https://t.co/pWmD4nKs6U

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Dr. John Cush RheumNow ( View Tweet)
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