ACR21 Best Abstracts We Saw - Day 3 (Monday)

Jack Cush, MD

Nov 08, 2021 11:32 pm

The third day of ACR 2021 took a big leap in online content. Here is a compilation (with links) of presentations were the “ACRBest” as seen by our RheumNow faculty.

Gender and Secukinumab Rx outcomes: Real life study pinpoints higher disease burden, severity of depressed mood & higher Mean ASAS-HI in Female pts w/AS. Secukinumab improved disease activity, global functioning and severity of depressive mood in AS patients in both men and women. Abstract# 0909
Is #COVID19 vaccine safe and effective in #lupus? YES!! VOCOLUP study (N=1189 pts) showed: ~45% had a side-effect; of which 80% mild/moderate; Only 3% flared post-injx (MSK + Fatigue); 10 required hospitalisation Abstract 1421
Methotrexate Nausea and Alopecia. Baseline factors associated with nausea and alopecia with MTX. Alcohol use (modifiable!) and female were associated with both. Disease activity associated with with nausea and HAQ with alopecia. Abstract# 1444
Predictors of Mortality in VEXAS. Median survival for pts with VEXAS was 10 years. Predictors of mortality = p.MetVal mutation HR 3.5 (95%CI, 1.4-8.5). Also transfusion dependency higher risk of mortality (HR 2.59; 95%CI, 0.94-7.09). But a lower risk with ear chondritis (HR 0.26; 95%CI,0.09-0.6). @marcelaferrada Abstract# 1426
Pulmonary Arterial Hypertension in #AOSD - Rare but severe life threatening complication - French study of 13 pts - ALL FEMALES! Age 32 yrs., mean f/u 34 months, 5 pts (38.5%) DIED. Association with Steroids, IL-1 Rx and female? Abstract# 1100
Two teens start their own podcast called “take a pain check” @takeapaincheck; a national podcast started by 2 teens (abstact authors) for teens with Rheumatic Disease. Abstract# PP11
Routine evaluation of MRE and MRI in Crohn's Disease could be a way to detect axSpA. 25% of 48 CD patients had abnormal SI joint finding, majority asymptomatic, female, and had stricturing or penetrating CD. Abstract# 1306
Majority of rheum pts on csDMARDs, TNFi, JAKi & TCZ had adequate serologic response to m-RNA based vaccines. Poor vaccine reactivity mainly assoc'd w/ RTX, steroids, and MMF. Study did not include ABA. Abstract# 1087
Glucocorticoids increase MACE in Rheumatoid Arthritis pts in a large VA population >23000 pts. Is it steroids, disease activity, concomitant comorbidities? Likely all of above. Even 30 days of steroids in last month increased CVE by 15% Abstract# 1428
While outcomes didn't worsen, de novo Psoriasis can occur at any time point in axSpA (results from 6 year, DESIR cohort study). Regular follow ups are key to monitoring. Abstract# 1311
JAK-pot Study: Cycling JAKi Compared to Switching to bDMARD in Patients Who Failed a First JAKi - Equal effectiveness of JAK to JAK switching in Rheumatoid Arthritis vs JAK to bDMARD. AE discontinuations with 1st JAK seemed to recur with 2nd JAK. Abstract# 1442