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Bad Actor Cofactor (10.17.2025)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports, discusses pediatric reports, pregnancy data, diet and nutrition and more.

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Arthritis Pain and Education Gaps Linked

EurekAlert!

New research from The University of Texas at Arlington shows that differences in state welfare policies are linked to rising arthritis-related joint pain across much of the U.S.

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Eating Crow (10.10.2025)

Jack Cush, MD

Dr. Jack Cush reviews the news, FDA approvals, and journal articles. In this episode: HMGCR Abs, FDA approvals and Cush eats crow.

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Gender Complexities in Psoriatic Arthritis Treatment Outcomes

Jack Cush, MD

Analysis of a German psoriatic arthritis (PsA) patients registry demonstrates sex-specific differences regarding clinical manifestation and treatment outcomes, especially with regard to drug discontinuations.

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Tramadol not effective at chronic pain

EurekAlert!

The strong opioid painkiller, tramadol, is not that effective at easing chronic pain for which it’s widely prescribed, finds a pooled data analysis of the available research, published online in BMJ Evidence Based Medicine.

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Hip

Hip Osteoarthritis Treated with Exercise plus Weight Loss Diet

Jack Cush, MD

An exercise and diet intervention study showed that while exercise improved hip pain, adding a weight loss diet to exercise did not change hip pain but improve most secondary outcomes.

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Only 32% of RA pts were satisfied with current txs. In a discrete choice experiment of 354 US pts, many preferred a vagus nerve stimulator over another biologic/JAKi, especially those with prior tx failures. Cost, function, and fatigue drove preferences. @RheumNow #ACR25 A#0370

Jiha Lee JihaRheum ( View Tweet)

From the plenary to posters, RheumNow is your companion for ACR Convergence 2025. Expect: • KOL videos • Clinical trial highlights • Daily faculty recaps • Live streaming #ACR25 #Rheumatology #ClinicalTrials https://t.co/zZAwYINmC2
Dr. John Cush RheumNow ( View Tweet)
Fibromyalgia in PsO & PsA is linked to greater treatment complexity and shorter biologic therapy survival. Retro matched 1:4 cohort study 61K PsO& 244K controls. FM prevalence 3.3% (OR 1.45). In PsA decr biologic survival (6 vs 10yrs) w/ incr switching (HR 1.82)

Dr. John Cush RheumNow ( View Tweet)

Arthritis Pain and Education Gaps Linked Save New research from The University of Texas at Arlington shows that differences in state welfare policies are linked to rising arthritis-related joint pain across much of the U.S. https://t.co/cGRH9X6pMZ https://t.co/J1SDeKrytn

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Dr. John Cush RheumNow ( View Tweet)
BMJ Systematic review of 217 RCTs w/ 15 684 pts shows most beneficial exercises for Knee Osteoarthritis are aerobic activities such as walking, cycling, or swimming significantly mitigated pain during both short and mid-term follow-up periods https://t.co/WmQBFNis6t https://t.co/KXv2mogvZx

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Dr. John Cush RheumNow ( View Tweet)
Scientific American takes a look at the beneficial effects of: Omega-3 Fatty Acids Vitamin D Curcumin (basic overview for all) https://t.co/jv5FrGQQLJ https://t.co/vP26OPaTiS

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Dr. John Cush RheumNow ( View Tweet)
Rheumatic and musculoskeletal disorders in musicians: Famous musicians/performers with Rheumatic dz and the most common disorders reviewed. https://t.co/FitQpg4KvC https://t.co/ch8V2WGJXm

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Dr. John Cush RheumNow ( View Tweet)
Tramadol not effective at chronic pain The strong opioid painkiller, tramadol, is not that effective at easing chronic pain for which it’s widely prescribed, finds a pooled data analysis of the available research, published online in BMJ Evidence Based Medicine. https://t.co/zFWwyy1j3O
Dr. John Cush RheumNow ( View Tweet)
Review of GLP-1 agonist use in rheumatology - with benefits beyond DM, obesity, improved survival, reduced major cardiovascular and renal events. Anti-inflammatory & chondroprotective effx shown benefit in knee OA & pain. GLP-1RAs do not prevent gout attacks. More research https://t.co/8zh18mlYDh
Dr. John Cush RheumNow ( View Tweet)
Systematic review of obesity management meds - 56 RCTs (60,307 pts). All OMMs were better at total weight loss than PBO (P < 0.0001), >10% semaglutide & tirzepatide (both effective at NIDDM CHF). Semaglutide effective reducing pain in knee osteoarthritis https://t.co/4MX2IiDC2X
Dr. John Cush RheumNow ( View Tweet)
Prediction of D2T-RA. Model was trained on BRASS pts (700; 16% w/ D2T-RA) & validated on CERTAIN pts (2,070; 28% D2TRA). PRO's were strongest predictors. Moderate predictive accuracy (C-index of 0.64 & 0.62) w/ functional status, pain, fatigue, and global Dz activity https://t.co/uv3uGYIRFb
Dr. John Cush RheumNow ( View Tweet)
Phase 3 RCT Cannabis sativa DKJ127 (VER-1) in 820 chronic low back pain (cLBP) pts. Primary endpt at wk 12 showed pain reduction of −1.9 NRS VER-01 vs −0.6 PBO (P < 0.001). Pain further decreased to −2.9 w/ 6 mos OL Rx. VER-1 was well tolerated. No addiction https://t.co/IeCV8tU2WR
Dr. John Cush RheumNow ( View Tweet)
Impact cumulative MTX on liver fibrosis? 1314 #PsA pts (age 44), 28% on MTX. Total of 44 (3%) had baseline liver fibrosis & 12% developed it over med/ 5.6 yrs. Cumulative MTX Did NOT assoc w/ liver fibrosis (OR 0.99), but high BMI & DM did (Metabolic factors) https://t.co/OSVZHskjB4
Dr. John Cush RheumNow ( View Tweet)
2019 National Health Survey of 87,678, 21% had chronic back pain (cLBP). cLBP had more Multimorbidity 62.1%, worse activity limitation. depression, and cardiovascular disease https://t.co/LFdWr0s6tg https://t.co/R5cZSWySUK

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Dr. John Cush RheumNow ( View Tweet)
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