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LRA Awards for Immune Resetting Therapies in Lupus

Lupus Research Alliance

Lupus Research Alliance (LRA), the world’s largest private funder of lupus research, in collaboration with Genentech, a member of the Roche Group, announced the inaugural recipients of t

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Trends and Innovations in Lupus Nephritis Clinical Trials

Jack Cush, MD

Xu et al. from Shanghai University have written an analysis of global lupus nephritis (LN) clinical trials and call for innovation.

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BE BOLD Week 16 data - Bimekizumab vs. Risankizumab in PsA

Jack Cush, MD

UCB has released the Week 16 results from BE BOLD trial that will be presented at EULAR 2026 in London on Saturday, June 6.

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A Role for Plasmacytoid Dendritic Cells in Lupus

Jack Cush, MD

Plasmacytoid dendritic cells (pDCs) have been strongly implicated in the pathogenesis of lupus, as their primary product, type I interferon, drive systemic lupus erythematosus and cutaneous lupus erythematosus. A recent comprehensive review synthesizes the available data on pDCs, and, importantly, what we still don't know.

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ABA versus HCQ in Palindromic Rheumatism

Jack Cush, MD

Palindromic rheumatism may develop rheumatoid arthritis (RA) and could be an at-risk population. A pilot trial compared abatacept (ABA) versus hydroxychloroquine and demonstrated ABA reduces RA development in a 2 year study. 

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Infectious Rheumatology (5.15.2026)

Jack Cush, MD

Dr. Jack Cush discusses his favorite journal articles from the past week on RheumNow.com.

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EGPA Review

Jack Cush, MD

A current review of eosinophilic granulomatosis with polyangiitis (EGPA) provides current recommendations on diagnosis and management.

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ACPA and the Transition from Arthralgia to Rheumatoid Arthritis Patients with clinically suspect arthralgia (CSA), a common prequel to rheumatoid arthritis (RA), showed different patterns of symptoms and progression depending on whether they tested positive for https://t.co/pCaYdEg1gZ
Dr. John Cush RheumNow ( View Tweet)
#EULAR2026 OP028 In 16 patients with AID (SSc,IIM, RA, IgG4,SjD, Grave’s), CD3xBCMA BiTE, Teclistamab was effective in 15/16. Duration of GC & DMARD-free was 11 mths. 2/16 need retreatment. All had low IgG and needed IVIG. Need long-term safety data & comparative study @RheumNow https://t.co/97MUPnXRua

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Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Interesting pilot study using line-field confocal OCT for CLE The “virtual biopsy” identified distinct layer-specific patterns across diff CLE subtypes including distinctions bet ACLE & rosacea (dil. vessels, demodex mites, periannexal infil) AbsOP099 @RheumNow #EULAR2026 https://t.co/yQSc6u4oYV

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sheila RHEUMarampa ( View Tweet)
❎HIGH Type 1 #interferon = Worse #scleroderma In both #limited #lcSSc & #diffuse #dcSSc Leeds cohort ?biomarker #EULAR2026 @RheumNow ABST#POS1092 ABST#POS0395 https://t.co/cRrBIpLgP9

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Janet Pope Janetbirdope ( View Tweet)

#EULAR2026 OP0126 Long-term extension study up to 108 weeks: Ianalumab demonstrated sustained efficacy (change in ESSDAI) including those who switched from PBO to IAN in #Sjogren. IAN improved most domains apart from lungs, MSK & Haem - important to note @RheumNow #EULARBest https://t.co/x1d4G1s0jw

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Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
#EULAR2025 OP0127 Still trying to get my head around the flat line PBO response. In Sjogren pts with ESSDAI=>5, a Phase 3 RCT of Telitacicept (BAFF/APRIL-i) in China met all endpoints. ESSPRI improved too! Could be because strict concom DMARD inc. GC protocol @RheumNow https://t.co/FEhXfNPvfG

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Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
You CAN identify #ILD in #rheumatic #diseases 🔜early With a brief #questionnaire Ask re ➡️dry cough ➡️dyspnea ➡️smoking Not sensitive but high #specificity Is it too late? Maybe chest #auscultation at the #bases would be better? 🤷 #EULAR2026 ABST#POS0433 @RheumNow https://t.co/JA3k1cSHt7

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Janet Pope Janetbirdope ( View Tweet)
Count Your Telangiectasias (5.29.2026) Dr. Jack Cush reviews the news, journal articles and missed quiz questions. https://t.co/KDXijQMdfr https://t.co/2Vi3MKZZbk

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Dr. John Cush RheumNow ( View Tweet)
True or False: NLRP3 inflammasome activation in neutrophils triggers PAD release, increasing citrullination of intracellular proteins and contributing to rheumatoid arthritis pathogenesis. See if you got it right in this week's RheumIQ quiz at https://t.co/DX0qT1iNF2 https://t.co/rVuQM3aeI2

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Dr. John Cush RheumNow ( View Tweet)
LRA Awards for Immune Resetting Therapies in Lupus LRA, the world’s largest private funder of lupus research, in collaboration with Genentech, a member of the Roche Group, announced the inaugural recipients of the Lupus Research Alliance-Genentech Award on Immune Resetting https://t.co/eDAq17lhM0
Dr. John Cush RheumNow ( View Tweet)
Case-control study of 349 autoimmune (ARD) pts (SLE, RA, SSc) & serum assays for anti-neutrophil extracellular trap (aNET)Abs. aNET in 37% SLE assoc w/ APS (OR 3.4) & arterial thrombosis (OR 5.5). aNET in 40% RA assoc w/ ACPA+ (p=0.049) https://t.co/QwvmLAVmg7 https://t.co/VJ7JV5fcZE

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Dr. John Cush RheumNow ( View Tweet)
Plasmacytoid dendritic cells (pDCs) have been strongly implicated in the pathogenesis of lupus, as their primary product, type I interferon (IFN-I), drive systemic lupus erythematosus (SLE) and cutaneous lupus erythematosus (CLE). A recent comprehensive review synthesizes the https://t.co/VaE295a2Ep
Dr. John Cush RheumNow ( View Tweet)
PTPN22 1858C>T allele, seen in 5-15% NAmerica, often assoc. w/ autoimmune dz risk. BUT...PNAS shows Ptpn22 augments innate immunity and enhances NK activity against coronavirus infection https://t.co/1AMTuOXtoT https://t.co/9f3JdimJsG

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Dr. John Cush RheumNow ( View Tweet)
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