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⚡️Pulmonary pulse wave transit time⚡️
👉novel non-invasive echo measure of ⬆️pulm vasc tone in pulm HTN
👉hyperuricaemic pts ⬇️pPTT sugg of pulm vasc dysfn
@FloodRachael #ACR22 Abst1788 @RheumNow https://t.co/ZEORWbqw6f
Patricia Harkins DrTrishHarkins ( View Tweet)
Still for me the most interesting bit from the GLORIA study (PNL 5 add-on in RA) is the coming off of it.
Patients were able to come off their long-term low-dose prednisolone. No Sx/biochem differences vs placebo.
True #squadgoals for rheumatologists
ABST2000 #ACR22 @RheumNow https://t.co/eQLcgqA1SN https://t.co/RGTCrMhld7
David Liew drdavidliew ( View Tweet)
Cumulative dose and exposure to methotrexate were not predictors of hepatic fibrosis.
Hepatic fibrosis as measured by elastography associated with daily EtOH use.
#ACRBest Abs#2147 @RheumNow #ACR22
Robert B Chao, MD doctorRBC ( View Tweet)
Peritonitis of the #FMF - misdiagnosed as acute abdomen
Acute appendicitis is the leading cause of acute abdomen in FMF
Turkish study 1655 #FMF pts
15.8% appendectomy rates!
CRP ineffective for differing FMF from appendicitis :(
@RheumNow #ACR22 abst#1839
Bella Mehta bella_mehta ( View Tweet)
Factors associated with non-achievement of MDA in PsA pts receiving golimumab:
Baseline tender joint count, fibromyalgia, older age, smoking, high BMI
Abs#2109 @RheumNow #ACR22 https://t.co/dEzQxVtavh
Robert B Chao, MD doctorRBC ( View Tweet)
‼️‼️Frailty ‼️‼️
👉Important predictor of serious infxn in RA pts on b- or tsDMARD irrespective of age ‼️‼️
@NamrataRheum illustrating yet another reason why it is so NB to evaluate 4 frailty in ALL (incl young) pts with RA
#GeriRheum
Abst2218 @RheumNow #ACR22 https://t.co/J4XQFmVoUw
Patricia Harkins DrTrishHarkins ( View Tweet)
While there are limitations to this study (respondents over childbearing age, white, educated, insured), within 2 months of @USSupremeCourt3's overturn of Roe v Wade, 1 in 17 MTX pts experienced a barrier to getting rx filled. ABS L09 @RheumNow #ACR22 https://t.co/WuikwO1bZ9 https://t.co/4Ve0zAVxbG
Dr. Rachel Tate uptoTate ( View Tweet)
Early psoriasis and enthesitis response in PsA pts treated with guselkumab predicted longterm clinical response including MDA, DAPSA LDA, DAPSA50, DAPSA remission.
Pts w/o early response, only half achieved remission
Abs#2115 @RheumNow #ACR22 https://t.co/dnsQcp7cEq
Robert B Chao, MD doctorRBC ( View Tweet)
BKZ showed clinically meaningful improvements in efficacy outcomes in bDMARD-naïve PsA pts at Wk 16 through wk 52. No new safety signals. ABS L02 #ACR22 @RheumNow https://t.co/Dph32O7NWG https://t.co/d7Yq3JISyF
Dr. Rachel Tate uptoTate ( View Tweet)
I think this has changed my mind!
Does RA benefit from changes in diet & exercise?
RCT Reade @amsterdamumc n=77
mod active RA
https://t.co/5Iw6hYJzGK for 16w:
whole food plant-based diet/exercise/stress management
0.9 improvement in DAS28 vs placebo!
ABST1998 #ACR22 @RheumNow https://t.co/u10RqmPMPd
Links:
David Liew drdavidliew ( View Tweet)
PsA bDMARD "ranking" system by systematic literature review looked at 30 RCTs
Highest probability of achieving ACR20 and PASI90: infliximab, golimumab and bimekizumab
#ACRBest Abs#2123 @RheumNow #ACR22 https://t.co/KpW0p2KAQZ
Robert B Chao, MD doctorRBC ( View Tweet)
🔥PrEP 4 SARS-CoV-2🔥
➡️casirivimab/imdevimab
⚡️Detection @ D1 and stabilisation up to D30 of serum and saliva Abs in IMID pts who failed response 2 COVID vax.
❓role in preventing severe infxn in high risk pts refractory 2 vax
#ACR22 @RheumNow Abst 2195 @Dr_David_Simon https://t.co/Zd00P5l363
Patricia Harkins DrTrishHarkins ( View Tweet)
Abstr # 1878 looked at biomarkers assoc w/ MRI muscle inflammation in #IIM
- Of the potential cytokines, IL-7 strongly correlated with muscle damage on MRI thigh bilateral
@RheumNow #ACR22 #Myositis https://t.co/3i3C2EGtFM
Akhil Sood MD AkhilSoodMD ( View Tweet)
Smartphone app (FM-ACT) - self guided 8 chapters of structured lessons, mindfulness practices and activities w/ paced exercise and behavior change proved beneficial after 12 weeks.
Improvement in all areas: pain, sleep, psychological wellbeing
Abs#2235 @RheumNow #ACR22 https://t.co/wNhIw4pdJu
Robert B Chao, MD doctorRBC ( View Tweet)
61pts with #FMF on Canakinumab - single center in Turkey
35% no attacks
attack frequency decreased in 55%
no response in 10%
- VAS score and inflammatory markers significantly improved
#ACR22 @RheumNow abst#1834
Bella Mehta bella_mehta ( View Tweet)
#abst0405 #ACR22 @RheumNow Post hoc of ph2/3 trials TOFA for AS: AEs/SAEs ⬆️ in pts w/BMI < 25 kg/m2 vs other BMI categories. Most frequent AEs (≥ 5% of pts) nasopharyngitis, URI& arthralgia. Δ from BL in LFTs similar, while % change from BL in lipid levels ⬆️ in Tofa vs PBO pts https://t.co/WmXD8uVK58
Olga Petryna DrPetryna ( View Tweet)
Males w/ sarcoidosis may be more likely to have cardiac involvement. Patients treated with s/bDMARDs had a high response rate as reflected by clinical and imaging improvement. Abs 1846 @RheumNow #ACR22 https://t.co/ibbf4Dckun https://t.co/ZvGxPNFjwm
Dr. Rachel Tate uptoTate ( View Tweet)
In bio-naïve PsA pts on GUS, earlier improvements in self-reported health-related measures were sustained through 2 years. Abs 1850 #ACR22 @RheumNow https://t.co/6yhPesE3LZ https://t.co/nVCSgPgcqW
Dr. Rachel Tate uptoTate ( View Tweet)
#ACR22 Abstr#L07 Most impressive Delta difference vs Control in #lupus! In Phase 3 RCT in China, more patients in Telitacicept, BAFF/APRIL-i met SRI-4 (delta 44% if data imputed; 34% without). No major safety. Phase 3 in US is in progress. Would be historic! @RheumNow #ACRBest https://t.co/8wL2tkA8ym
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Jonassen et al. AP1189, an oral melanocortin agonist in combination with MTX in early RA. Evidence of efficacy, no safety concerns. Looks promising! @RheumNow #ACR22 Abstr#1985 https://t.co/aK7BPwr5Ku https://t.co/9553KT2Pao
Richard Conway RichardPAConway ( View Tweet)