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Primer on Clinical Trials

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d Jack Cush, MD

Oct 14, 2022

In this week's special podcast, Dr. Jack Cush offers a primer on rheumatology clinical trials, answering the question: should you be involved in research and clinical trials in rheumatology?

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Predicting Cardiovascular Events in SLE

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d Jack Cush, MD

Oct 13, 2022

A study from the Georgia Lupus Registry shows that systemic lupus erythematosus patients are at greatest risk for cardiovascular disease events between years 2 and 11 after diagnosis and higher in Black people or those with a discoid rash.

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Second Efforts in Treating RA Partial Responders

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d Jack Cush, MD

Oct 12, 2022

The results of a treat-to-target (T2T) combination therapy trial in patients with early rheumatoid arthritis (RA) show that if patients fail to respond initially, then a second, more intensified regimen can turn initial nonresponders into responders.

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ACR Announces 2022 Award Recipients

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d ACR

Oct 12, 2022

The American College of Rheumatology (ACR) and the Association of Rheumatology Professionals (ARP) proudly recognizes the recipients of its 2022 Master of the ACR and ARP designations, ACR Awards of Distinction, and ARP Awards of Merit and Appreciation.

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Good Outcomes with TNF Blocker Use During RA Pregnancies

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d Jack Cush, MD

Oct 11, 2022

A prospective cohort study of treatment and pregnancy outcomes in women with RA shows that TNF inhibitor use during pregnancy did not increase the risk of adverse pregnancy outcomes, but instead led to more positive outcomes such as fewer low-birth-weight deliveries.

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ACR Announces 2022 Award Recipients The ACR and the ARP proudly recognizes the recipients of its 2022 Master of the ACR and ARP designations, ACR Awards of Distinction, and ARP Awards of Merit and Appreciation. https://t.co/sB3IfvFBJD https://t.co/w8J4qFPvpF

Links:

https://bit.ly/3SZZEZq

Dr. John Cush RheumNow ( View Tweet)

Oct 14, 2022

Do you renal Bx your #SLE pts? Study of 277 SLE pts w/ US-guided percutaneous renal bx showed bleeding complications post biopsy to be 19.9% (minor 13%; major 7%); risk higher w/ thrombocytopenia (OR 7.12)low eGFR (OR 3.5) https://t.co/kYieyYTUuT https://t.co/ZGobCIcW6v

Links:

https://bit.ly/3TemlsH

Dr. John Cush RheumNow ( View Tweet)

Oct 14, 2022

EMA CHMP issued a positive opinion on the safety of Filgotinib, a selective JAK1 inhibitor, based on testicular safety data from the MANTA & MANTA-RAy studies. Gilead withdrew filgotinib from US market w/ FDA concerns on testicular safety in 12/20 https://t.co/EawqOGZEZe https://t.co/Bcp6rOReCR

Links:

https://wb.md/3ClfCGo

Dr. John Cush RheumNow ( View Tweet)

Oct 13, 2022

NEJM: 70 yoWM w/ 3-wk temporal headaches, jaw pain with chewing, temporal artery tender and thickened, but NO vision Sxs. a 15, CRP 24 mg/L. and Doppler US showed “halo sign” . Temp art Bx confirmed the Dx of GCA https://t.co/mIUA8pMh2l https://t.co/o50MkidinC

Links:

https://bit.ly/3VhlglT

Dr. John Cush RheumNow ( View Tweet)

Oct 13, 2022

J Rheum review shows 4,444 rheums in 2015 & 3,547 in 2020 recv some sort of pharma payments (There are ~5000 US Rheums). Pandemic drops affected travel, etc (98%), speaking (72%), meals (72%), but less consulting (23%) https://t.co/2UMqp4XDhJ https://t.co/dHtHUBO1Wk

Links:

https://wb.md/3g2BMWq

Dr. John Cush RheumNow ( View Tweet)

Oct 13, 2022

Downstream revenues from Rheum? The Rheumatologist reports and impt reference showing for every $1 dollar office visit billed, $12.14 generated in downstream revenues (infusions, labs, surgery). Cognitive specialists are undervalued! https://t.co/YatkwrBCeQ https://t.co/OzSsxXKVhC

Links:

https://bit.ly/3Ew86LM

Dr. John Cush RheumNow ( View Tweet)

Oct 13, 2022

Review of risk factors for osteoporosis and fractures in #RA. OP Risk factors same as gen population (but more prevalent in RA) - smoking, calcium intake, vit D deficiency, hypogonadism and chronic exposure to glucocorticoids https://t.co/KsE5ag29ZN https://t.co/OQtfoKcIX2

Links:

https://bit.ly/3RM1N9H

Dr. John Cush RheumNow ( View Tweet)

Oct 13, 2022

Co-administration of MTX with Folic Acid on the same day did not reduce efficacy compared to FA application one day after MTX. (based on AIA was induced in female Lewis rats) https://t.co/gBWhjhS8Nu https://t.co/5799lleK22

Links:

https://bit.ly/3T9BcES

Dr. John Cush RheumNow ( View Tweet)

Oct 12, 2022

Urine proteomics on 54 SLE pts in the Belimumab–Lupus Nephritis trial, compared responders (n 31) v non-responders (n 22), on BEL or SOC. Reduction in urinary CD163 was strongly associated with complete renal response @wk52 & CD23 @wk24 https://t.co/Rais8fKame https://t.co/F3B9W7u7VO

Links:

https://bit.ly/3CqQsWT

Dr. John Cush RheumNow ( View Tweet)

Oct 12, 2022

No Special Heart Risk With JAK Inhibitors, Study Finds Patients taking JAK inhibitors for RA experienced similar cardiovascular outcomes as those using the TNF blocker adalimumab (Humira), analysis of French national registry data indicated. https://t.co/oUt1hz88ll https://t.co/RkUUvfC4YK

Links:

https://bit.ly/3CM4Pph

Dr. John Cush RheumNow ( View Tweet)

Oct 12, 2022

Arthritis Clinical Trials Comparison Grid https://t.co/rLxTauJqX1 https://t.co/U7i5baSNwt

Links:

https://bit.ly/3SU5bAY

Dr. John Cush RheumNow ( View Tweet)

Oct 12, 2022

Sjogrens - Dx tips, myths & mistakes: • SS not rare; affects 1 in 400 • 95% female, but SS is more severe in men • African Americans have a severe systemic phenotype • Asians report dryness Sxs • Smoking & alcohol intake often avoided by SS pts https://t.co/B2hR7z8H5Z https://t.co/g0FKhcmoXa

Links:

https://bit.ly/3Vjynme

Dr. John Cush RheumNow ( View Tweet)

Oct 12, 2022

Actual video of needle arthroscopy in patients w/ suspected septic arthritis. https://t.co/tWgP4ZpFBJ https://t.co/cLWM48NBlA

Links:

https://bit.ly/3el6ObH

Dr. John Cush RheumNow ( View Tweet)

Oct 11, 2022

Biomedical researchers are at their most creative/innovative EARLY in their career. Study based on 5.6 million papers (1980 to 2009). While least innovative drop out early; in the remaining, innovativeness tends to decline over their career.https://t.co/XY5xQfY8Ba https://t.co/Cs3MUr7qIi

Links:

https://bit.ly/3erTtON

Dr. John Cush RheumNow ( View Tweet)

Oct 11, 2022

Large retrospective claims data analysis of 86 964 adults w/ severe obesity and NAFLD: comparing bariatric surgery (35%) to those with nonsurgical care. Bariatric surgery lowered the risk of CVD by 49% https://t.co/xEVVQVEX30 https://t.co/gSUIeH1K0k

Links:

https://bit.ly/3EtbaIw

Dr. John Cush RheumNow ( View Tweet)

Oct 11, 2022

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