Skip to main content

High Mortality Rates with Depression in Rheumatoid Arthritis

Jun 14, 2023 5:32 pm

A Danish cohort study has shown a deadly association between depression and rheumatoid arthritis (RA).  

Using data from the national Danish rheumatologic database, DANBIO, they identified incident RA patients (between 2008 to 2018) and five random non-RA comparators. Drug use (antidepressants), socioeconomic status, mortality, and cause of death were identified from other registers. 

RA patients with depression had a significantly elevated all-cause mortality (adjusted HRR 5.34; 3.02, 9.45) in the first 2 years and overall was 3 fold higher than RA patients without depression (HRR 3.15; 2.62, 3.79). Mortality was highest in patients <55 years (HRR 8.13; 3.89, 17.02).  The most frequent natural causes of death were cancer, cardiovascular disease, stroke, and pneumonia.

A similar increase in all-cause mortality was seen comparing non-RA patiets with depression versus those without depression.

Depression is a significant predictor of death, in RA and non-RA patients.


If you are a health practitioner, you may to comment.

Due to the nature of these comment forums, only health practitioners are allowed to comment at this time.

The author has no conflicts of interest to disclose related to this subject