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Dr. Kathryn Dao reviews abstract L04 - Influenza Adverse Events in Patients with Rheumatoid Arthritis in the Tofacitinib Clinical Program - at the 2020 ACR annual meeting.
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There is much controversy regarding vaccine safety and efficacy in the United States. Prior to COVID19, there were populations who lacked confidence in vaccination for any number of reasons. Dr.
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Portland-based Dr. Kevin Winthrop from OHSU discusses Saturday ACR 2020 posters #0623 and #0629 related to COVID-19 and rheumatic disease patients.
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Here are my highlights from day four, Monday, of the ACR 2020 Convergence.
Vaccine Immunogenicity with Tofacitinib
Dr. John Cush
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Great read! "The Vaccine Review Process and Why You Should Know It" by Dr. Rachel Tate ( @uptoTate)
https://t.co/l39qH3LuXm https://t.co/PR1AaQCD7V
Dr. John Cush
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New podcast out now on our site #ACR20
Mid-Meeting Recap: Psoriatic Arthritis, Gout Patient Outcomes on Low-Dose Steroids, Giant Cell Arteritis Panel Vaccination w/ Shingrix: Does it work for patients on JAKi? Is it safe?
https://t.co/roc1Qjec5R https://t.co/gSkkj2Kl0m
Elizabeth Graef
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📌 #ACR20 Checkpoint Inhibitors: Past, Present and Future
👉close surveillance ➡️ early detection of iRAEs➡️ early treatment➡️ reversibility or ⬇️severity
#ACRAmbassador https://t.co/AM2mfYmAtI
Dr. Rachel Tate
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"The goal of a vaccine is not just to protect a (vaccinated) individual, but to end the pandemic." Dr. Dan Barouch #ACR20 @RheumNow
Jeffrey Curtis
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Interesting Swedish abstract 1997 at #ACR20. Adjuvant #herpeszoster vaccine (Shingrix) not effective for 25% of JAKi-treated RA pts (n=40) for antibody response (T cell response usually worse, not reported). Is better than nothing good enough? Maybe we need to hold JAKi briefly?
Adam J Brown
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Just watched David Beck’s talk on somatic mutations in VEXAS. Genotyping to link phenotypically diverse disease. Such an exciting strategy to identify additional unknown diseases!!! #ACR https://t.co/gU9HEZyjRP
Mrinalini Dey
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Prelim. results: Immunogenicity of adjuvanted #HerpesZoster subunit #vaccine in #RheumatoidArthritis patients taking #JAKinhibitors
- Most RA pts on JAKi have sufficient antibody response to HZ vaccine
- Acceptable safety profile
Abs#1997 #ACR20 @RheumNow
https://t.co/8HWAIwOATD
David Liew
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Just a reminder:
inflammatory arthritis irAEs can occur at almost any time after immune checkpoint inhibitor cancer immunotherapy is commenced.
@LoyolaChicago #ACR20 ABST1566 @RheumNow https://t.co/qdEpNpzdNs
Richard Conway
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Dr Kaellmark reports on immunogenicity of adjuvant herpes zoster subunit vaccine in RA patients treated with JAKi. 40 RA patients and 20 controls. Satisfactory serological responses and tolerability seen. @rheumnow #ACR20 Abstr#1997 https://t.co/UlDe4NllU0
Richard Conway
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Dr Winthrop reports on rates of influenza in RA in tofactinib clinical programme over 14-15 seasons. No significant differences in rates between tofa, ADA, MTX, and placebo. @rheumnow #ACR20 Abstr#L04 https://t.co/8RrG0I2Zwm
Meral K. El Ramahi, MD
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Retrosp study in France compared MRIs of 96 pts w/ SpA (65% w/ IBP) vs 104 w/o (25% w/ IBP):
- 65% of pts w/ SpA had bone marrow edema (BME) mainly in the iliac quad of intermed middle segment
- 20% w/o SpA had BME mainly in antero-middle quad. #Abst1535 #ACR2020 @RheumNow https://t.co/1ptGGUbUS4
sheila
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How often do you perform NFC in suspected SSc patients? @RheumNow #ACR20
David Liew
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Our RA patients are susceptible to a dangerous virus which runs rampant, but won't take the vaccine.
Why won't patients have their flu shot? @McGillMed 40% hesitant despite public funding. Multiple levels influence; if we don't address, our pts suffer!
#ACR20 ABST1740 @RheumNow https://t.co/1Yhr6I2L30
Dr. Rachel Tate
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I just reviewed the #ACR20 talk regarding vaccination. Highly recommended/timely given data released from Pfizer today regarding the COVID-19 vaccine trial. @RheumNow
Pfizer’s Early Data Shows Vaccine Is More Than 90% Effective - The New York Times https://t.co/Fb5ZepCBeJ
Dr Irwin Lim
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Why care about Sleep? Sleep & Its Immune implications
#ACR20 https://t.co/hUXPiKc1Kg
Eric Dein
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Are you talking RA patients about vaccination? Abst#1465 shows S pneumonia vaccinations decreases pna by nearly half in <65 yo, as well as effectiveness in elderly. Theme of day: approach ifn and CV risk are best rheum interventions! @Rheumnow #ACR20 https://t.co/ZilXfFWTUM
