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Rheumatoid Arthritis Patients Need to Quit Smoking ASAP

d Jack Cush, MD

While it is known that smoking ups the risk of developing RA, its effect on outcomes in those with established rheumatoid arthritis (RA) is less known.  A report from an early arthritis registry shows that current smoking increases disease activity and lowers health-related quality of life.

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Causes of Death in Lupus

d Jack Cush, MD

The California Lupus Surveillance Project has longitudinally followed included systemic lupus erythematosus (SLE) cases and shown that overall, the leading cause of death was cardiovascular disease (CVD), followed by rheumatic disease and hematologic/oncologic conditions.

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IL-17 Switching Works in Psoriatic Disease

d Jack Cush, MD

Analysis of data from a Czech nationwide registry of psoriatic patients receiving biologic or targeted therapies (BIOREP) has shown a high success rate when switching between specific IL-17 inhibitors.

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Microbioime analyses of cancer patients suggests over abundance of fungi, expecially transcriptionally active Candida and is associated with gastrointestinal and lung cancers. Candida DNA is also predictive of reduced survival in GI cancers https://t.co/YoMOvvskqz https://t.co/6hC6Y4YAc1

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New look at fibrosis in scleroderma finds low levels of the antifibrotic protein, endostatin & Cathespin L. In vitro studies show a deficiency of Cathepsin L that should lead to its activation of antifibrotic endostatin - possibly a new Rx strategy for SSc https://t.co/qaLN0PVnLO https://t.co/TDK4sBZMV0

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COVID-19 Arthropathy and Myalgia An online survey of random COVID-19 infected persons shows that arthralgia and myalgia are common consequences to COVID-19 infection. https://t.co/TbJvTRfsvk https://t.co/yuLN5p5ZAn

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Dr. Alfonse Masi donates $1.2 Million to establish the Masi endowed chair in Medicine at the University of Illinois College of Medicine, Peoria. Dr. Masi is a giant clinician, researcher, epidemiologist in Rheum w/ > 220 Pubs & Yrs service to the ACR https://t.co/MbCFVZyNs1 https://t.co/LQ9D0ypA53

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2022 Lasker Award Winners Widely regarded as America’s top biomedical research prize since its creation more than 75 years ago by Mary and Albert Lasker, the Lasker Awards carry an honorarium of $250,000 for each category. https://t.co/wBIGMR6lH7 https://t.co/t9HUECimys

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Opioid Crisis Costs USA $1.5 Trillion Reuters has reported the results of a Congressional report showing the economic toll of the opioid addiction and overdose crisis on the United States reached nearly $1.5 trillion in 2020 alone and is likely to grow. https://t.co/Fwk6jDdtiD https://t.co/91d26iEZts

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This week it's the great and not-so-great on gout, chondrocalcinosis, osteoporosis and misdiagnosis. We are good at many of those things - what's not so great? Let's review the news and journal reports from the past week on RheumNow. https://t.co/30Ih3xj22t https://t.co/YznOuGg5B2

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2 open-label reports of JAK inhibitors in Systemic sclerosis (SSc) - 59 SSc pts: significant decr in mRSS in 88%. 28/29 w/ ILD had no progression. Overall responses better in treatment naïve SSc patients. 20% had side-effects. More studies needed https://t.co/PPAHocDWBj https://t.co/hZDGOF6r9k

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Five Senses of Medicine - nice graphic download on Clinical Skils (from Annals of Internal Medicine) https://t.co/8RNpqovtVP https://t.co/FkOSZCtv8c

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Efficacy and Safety of JAK Inhibitors in Psoriatic Disease There is a growing body of evidence demonstrating efficacy and safety of JAK inhibitors in patients with moderate-to-severe PSO and PsA, according to a systematic review in BMC Rheumatology. https://t.co/8Y4V1jUlzo https://t.co/eFqknUfGat

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Study of 67 OA TKR pts looked for CPPD - defined as "appears as linear/punctate opacities w/in cartilage, synovium, Jt capsule or tendons/entheses". Xrays had specificity of 92%, sensitivity 54%, PPV 88%, NPV 66% (needs to be distinguished from BCP) https://t.co/i0ZagblzPZ https://t.co/CiusWPzjrK

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Are We Overcautious With TNF Inhibitors in Pregnancy? What may seem like a prudent approach to treatment of IBD in pregnant women actually represents an overabundance of caution, suggested researchers who found no increased risk from TNF inhibitors. https://t.co/gYqJDBHTBQ https://t.co/aBXl49wJzM

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Long term results of KEEPsAKE 1 and 2, RCTS of SKYRIZI (IL-23 inhibitor) in active #PsA pts were presented at EADV mtg in Milan. At wk 100, showed more than half of PsA patients achieved PASI 90 & ACR 20 responses. https://t.co/ZJsR0R5WNW https://t.co/2GU5aaSwDZ

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IL-18 is a proinflammatory cytokine involved in innate &adaptive immune responses. IL-18 is a key mediator in autoinflammatory diseases, MAS, Still’s disease. Serum IL-18 levels may be useful in diagnosis and monitoring of disease activity https://t.co/P8ecLAtNx5 https://t.co/3mo1vcYKUr

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Cancer Risk with Scleroderma Spanish Scleroderma Registry examined a large cohort of systemic sclerosis (SSc) patients showing an increased cancer risk, especially breast, lung, hematologic and colorectal cancer. https://t.co/2sCI6AejRn https://t.co/estX9D39tZ

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Is PMR the Next Indication for Tocilizumab? About half of patients with steroid-dependent PMR were able to get off steroids altogether when they were started on tocilizumab (Actemra) infusions, a randomized phase III trial showed. https://t.co/fe8d6LNMOh https://t.co/RLhnaEPOVK

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Dr. John Cush RheumNow ( View Tweet)
This week it's the great and not-so-great on gout, chondrocalcinosis, osteoporosis and misdiagnosis. We are good at many of those things - what's not so great? Let's review the news and journal reports from the past week on RheumNow. https://t.co/8hICpPVC8b https://t.co/GDHaBb6fFC

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Dr. John Cush RheumNow ( View Tweet)

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