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AI,genes

SOCS1 Insufficiency - a Rare Inborn Error of Immunity

Jack Cush, MD

Lancet Rheumatology has published a population study of the rare suppressor of cytokine signalling 1 (SOCS1) insufficiency - an inborn error of immunity affecting the negative regulation of cytokine and growth factor signalling.

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Opioid Deaths are Down (2.28.2025)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com.  Opioid deaths are down, IL-33 levels are up and Weight loss is in the news again this week!

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Postoperative Weight Loss Improves Joint Replacement Survival

Jack Cush, MD

A cohort study of shows that postoperative weight loss with antiobesity medications significantly reduced the risk of 5-year and 10-year revision among patients with obesity undergoing hip or knee replacement.

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B Cell Depleters (2.21.2025)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com.

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AI-assisted diagnosis for immunological disease

EurekAlert!

A novel machine learning framework – Mal-ID – can decipher an individual’s immune system’s record of past infections and diseases, according to a new study, providing a powerful tool with the potential for diagnosing autoimmune disorders, viral infections, and vaccine responses with precision.

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Growing Physician Enthusiasm for AI in Healthcare

Jack Cush, MD

The AMA has just published the results of a U.S. Physician survey and shown MD attitudes have positively shifted regarding the use of artificial intelligence (AI) in healthcare.

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The Cartel is Coming for Rheumatology

Eric Dein, MD

"What Do Blockbuster Drugs & The Black Market All Have in Common?" asked Dr. Madelaine Feldman at RheumNow Live 2025. They thrive, she explained, on market exclusivity "... until they don't." At first glance, the pharmaceutical marketplace may not appear like a crime drug ring, but Dr. Feldman of Tulane University described how sinister forces of market manipulation have negatively impacted patient care for years.

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UK MRCP exam makeup: Cardio 15% Pharm 15% Resp 10% GI 10% Neuro 10% ID 8% Endo 8% RHEUM 6% Heme 5% Renal 5% Derm 4% Eye 2% Psych 2% https://t.co/WG7X3B8a0Y https://t.co/9VF5LkLJjs

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Dr. John Cush RheumNow ( View Tweet)
Bubble Trouble - When Bullous Lupus Bursts onto the SLE Scene Presentation by Dr. Alana Haussmann at the Rheumatology Winter Clinical Symposia - Feb 2025 https://t.co/bkQSq51BEo https://t.co/DLBs3uIyH7

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Dr. John Cush RheumNow ( View Tweet)
B Cell Depleters (2.21.2025) Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow. https://t.co/PRjy4a1BG9 https://t.co/3J4NSmn6Su

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Dr. John Cush RheumNow ( View Tweet)
Medicare study of 2.3 million shows high Telemedicine use was assoc w/ slight increase in visits (F2F & telemed), modestly lower use of 7 of 20 low-value screen tests for cervical CA, ECG, CMP, CBC, TFTs, & imaging for uncomplicated LBP (with less costs too)… https://t.co/lrG9NJ20B7 https://t.co/rLkGdBqWmr
Dr. John Cush RheumNow ( View Tweet)
Seeing Beyond the Surface: Salivary Gland Ultrasound in IgG4 Related Disease Presentation by Dr. Amy Trang at the Rheumatology Winter Clinical Symposia - Feb 2025. https://t.co/DLXKCRz3fF https://t.co/lfobyjElFG

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Dr. John Cush RheumNow ( View Tweet)
Growing Physician Enthusiasm for AI in Healthcare The AMA has just published the results of a U.S. Physician survey and shown MD attitudes have positively shifted regarding the use of artificial intelligence (AI) in healthcare. https://t.co/7nGn5XsfEI https://t.co/sH3yQtaQue

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Dr. John Cush RheumNow ( View Tweet)
The Cartel is Coming for Rheumatology At first glance, the pharmaceutical marketplace may not appear like a crime drug ring, but Dr. Feldman of Tulane University described how sinister forces of market manipulation have negatively impacted patient care for years.… https://t.co/nOllJFR9AQ https://t.co/IxyGaysOEe
Dr. John Cush RheumNow ( View Tweet)
Valentine RNL 2025 Review (2.14.2025) Dr. Jack Cush reviews highlights from RheumNow Live 2025 held in Dallas, TX on Feb. 8-9, 2025. https://t.co/EDCqmtbkyC https://t.co/2GlrslkgGp

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Dr. John Cush RheumNow ( View Tweet)
That's not my problem - or is it? Multimorbidity in RA RA can look so easy on the television commercials where patients appear young, healthy, and vibrant on the advertised treatment. https://t.co/4lSVKeRtyx https://t.co/Xa1UGbJigy

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Dr. John Cush RheumNow ( View Tweet)
NRMP Publishes 2025 Match Results. Rheumatology Stats: - Ped Rheum #5 in # U.S. DO grads (30%) - Adult Rheum #5 in Intl Med school grads (34%) - Adult: 3/132 progr. went unfilled (Ped: 20/36 unfilled) https://t.co/AsfOZMydMK https://t.co/Dim3hCLzXC

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Dr. John Cush RheumNow ( View Tweet)
EGPA in 2025 Eosinophilic Granulomatosis with Polyangiitis (EGPA), the artist formerly known as Churg-Strauss syndrome, remains somewhat of a rogue agent among the vasculitides. https://t.co/4ofjQRYsMH https://t.co/PoVhaQ9QiZ

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Dr. John Cush RheumNow ( View Tweet)
TheDaoIndex @KDAO2011 80% #hydradenitis suppurativa pts are smokers or former smokers, smoking can predate #HS by 4-5 years. Other associations: DM-2, Spa, obesity, SAPHO, PCOS eval for SCC (squ. cell CA) #RNL2025 https://t.co/XHrFseiAMK
Dr. John Cush RheumNow ( View Tweet)
Eric Dein @ericdeinmd Active Morphea: - MTX +/- steroids. If not effective, MMF/RTX/ABA - Topicals for circumscribed - Phototherapy Most pts achieve remission in active in 1 year Inactive morphea - Can address with PT, pain rx, psychological support, plastic surgery fat… https://t.co/OMGt8feO0z https://t.co/yWAgY2Z4Ng
Dr. John Cush RheumNow ( View Tweet)
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