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Is Alzheimer's Risk Lower With TNF Inhibitors?
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MedPage Today
Tumor necrosis factor (TNF) inhibitors for rheumatoid arthritis were linked with a lower risk of Alzheimer's disease and related dementia, but only in people with cardiovascular disease, data from the DREAM (Drug Repurposing for Effective Alzheimer's Medicines) study showed.
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RheumNow Podcast – What You Do For & What You Do To the Patient (4.8.2022)
Dr. Jack Cush reviews the news and journal articles from the past week and discusses the use of fibroscan in RA, steroid hip injections in OA and famous quotes from a famous cardiologist.
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Cell has a novel analysis using single-cell analysis of skin/blood from 56 controls & 97 diffuse systemic sclerosis pts, finding stromal abnormalities in LGR5+-scleroderma-assoc fibroblasts (ScAFs). ScAFs are decreased early & progressively https://t.co/Khxejd1fnq https://t.co/OrMAJnPTZt
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ArthritisPower study of 332 #PsA pts finds patients are most bothered by joint pain, MSK pain & fatigue. Patients prefer oral, QD meds; 3/4 want Rx that improved joints vs skin; and would prefer to avoid MTX https://t.co/WYqWgoimOT https://t.co/RgGeCKrpT1
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2020 Pt preferences survey- 137 #PsA pts most took TNFi (30%), IL-17i (20%), MTX (10%). From 2018 to 2020 a signif incr in IL-17i & PDE4 inhib. Pts want Rx for damage (80%), ADL (71%), & pain (70%) https://t.co/2dyIuQubh5 https://t.co/sFbtRj0Lbv
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ICYMI: Deucravacitinib, TYK2 inhib, studied in phase II trial 203 active PsA pts randomised to PBO, or DEUC 6 mg or 12 mg qd. At wk 16 ACR-20 responses were significantly higher with DEUC 6mg (53%, p=0.0134) and 12 mg (63%, p=0.0004) vs PBO. https://t.co/UOPteZY0g8 https://t.co/Xw3ZSPWeE0
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ICYMI: Differences between Palpated & Ultrasound Joint exams in 155 #PSA patients. 5616 joints - found 18.5% tender, 9.8% swollen, 20.4% w/ US GS ≥ 2 and 5.2% had US PD ≥ 1. Joints that were both tender and swollen more likely to have GS ≥ (44%) https://t.co/M6y5Gezhjs https://t.co/HYoI3pExRm
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Dr. John Cush RheumNow ( View Tweet)
ICYMI:The Enthesitis Challenge in Psoriatic Arthritis
A colleague of mine told me an interesting story about how her father, who was a doctor, misdiagnosed his wife with fibromyalgia when she actually had PsA with enthesitis all along.
Read more...
https://t.co/bSYdtlL41J https://t.co/gKKdWTvyMB
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Dr. John Cush RheumNow ( View Tweet)
ICYMI: TNR Recap: What Patients Say About PsA
Watch Tuesday Nite Rheumatology, held on 4/5/22,which featured a Patient Perspectives panel discussion, hosted by Dr. Jack Cush.
PsA Panelists included:
- Tena Brown
- Christine Lindsay
- Ashley Krivohlavek
https://t.co/FyjnzrtKqp https://t.co/uEHsoAwHLY
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Dr. John Cush RheumNow ( View Tweet)
ICYMI: Dactylitis Indicates a Severe PsA Phenotype
https://t.co/7VVoc0f1Ap https://t.co/uZxfqLvtcp
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Dr. John Cush RheumNow ( View Tweet)
ICYMI: 520 RA pts were screened with FibroScan (liver fibrosis)- F3 or F4 liver fibrosis seen 13.3% of controls vs 12.7% arthritis pts. MTX was not significantly correlated w/ higher FS scores. Liver stiffness was correlated w/ BMI, waist, male , age. https://t.co/PxrabHROPy https://t.co/UAw51Hb5vU
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Humbled to lecture at the #StaabSymposium with rheum greats @RheumNow and @KeithReich3 https://t.co/RHM1oneIc3
TheDaoIndex KDAO2011 ( View Tweet)
What I learned... always get an ALP and phosphorus level in people with chronic bony pain. https://t.co/nE0xYwODmC
TheDaoIndex KDAO2011 ( View Tweet)
Useful TST (PPD)/IGRA interpreter website for TB testing. A 31 yoM Texan w/ +IGRA only (true pos) has risk of active TB & INH hepatitis 0.1% & 0.4%. But if this was 60 yoF from Iraq on TNFi & pred the same risks are 20% & 2.3% https://t.co/M18cHuLrXu https://t.co/zIoFY4abXN
Dr. John Cush RheumNow ( View Tweet)
ICYMI: Metanlysis of psychological interventions for chronic low back pain (97 RCTs, 13,136 pts) finds that Only behavioural therapy delivered w/ physiotherapy care (mainly structured exercise) reduced pain intensity up (high quality evidence) https://t.co/56pMRVk0ic https://t.co/wxcfninf14
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Dr. John Cush RheumNow ( View Tweet)
ICYMI: Review of 5 trials shows ixekizumab with higher rates of complete skin & nail clearance compared H2H against to etanercept, guselkumab, ustekinumab, and adalimumab (Data from IXORA-R, IXORA-S, UNCOVER-2, UNCOVER-3, & SPIRIT-H2H trials https://t.co/t5wrmE3nbK #PsA #PsAlways https://t.co/MQjgktOZWR
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Dr. John Cush RheumNow ( View Tweet)
RheumNow's PsA Campaign with enhanced coverage of Psoriatic Disease is sponsored by Janssen. All content is chosen by RheumNow + its faculty. #PsAlways https://t.co/gHmZs3SW9S
Dr. John Cush RheumNow ( View Tweet)
Join us on April 12th for Tuesday Night Rheumatology at 7pm ET.
This week will host a conversation between Dr. Cush and Dr. Artie Kavanaugh on PsA medical journal articles.
Register today: https://t.co/YQD598xt7X https://t.co/k5uDeojEh7
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Dr. John Cush RheumNow ( View Tweet)
Depression was studied in 208 #PSA patients - Depression was found in 30%. Depression risk was higher in those with higher disease activity (DAPSA; P=.007) and functional impairment (HAQ-DI; p=-.02) https://t.co/0bZ2xPprTp https://t.co/Gdiic5iKCi
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Dr. John Cush RheumNow ( View Tweet)
Survey Question for RHEUMATOLOGISTS ONLY - Glucocorticoids are only used in #PsA under what circumstance? ANSWER here>> https://t.co/lqdZilbogR https://t.co/XxnOu9cQk3
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Dr. John Cush RheumNow ( View Tweet)