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A multinational registry analysis of rheumatoid arthritis (RA) receiving abatacept (ABA) has shown that the safety profile of ABA remains unchanged with no new or increased risks of infection or malignancy.
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New recommendations on imaging for crystal-induced (gout, CPPD) arthritis (CiA) were presented at EULAR 2023 in Milan.
Dr. John Cush
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Using Optum claims data from 2009 to 2021, they identified 524 IgG4-RD pts (mean age 56 yrs), incidence increased over time 0.78 to 1.39/100K Pt Yrs 2015 and 2019. Prevalence (1/19) was 5.3/100K Pt-Yrs, w/ mortality rate 3.42/100 Pt-Yrs (HR 2.51) https://t.co/22eIjtC7kp https://t.co/8RlEtZiX9j
Dr. John Cush
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Rheums! Have a rheumatology question or case for Jack Cush? Record it here and we may feature it on an upcoming podcast. Tell us your name and where you practice rheumatology.
https://t.co/3atPdJwb1m https://t.co/MKbgzEi9pd
Dr. John Cush
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NY Times article on a Moral Crisis for Americas doctors - the corporatization of Medicine leverages finances/incomes against physican values and practice preferences. Rheum Dr. Diana Girnita presents the Direct Medical Care option for MD autonomy https://t.co/TySD8l6I94 https://t.co/ZNTx7VVRfg
Dr. John Cush
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EULAR 2023 Notes from Milan
https://t.co/cdmkiJmQrz https://t.co/w6UV85bFQ1
Dr. John Cush
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Watch: A Real Boost for Shingrix with JAKi
Dr. David Liew discusses OP0225 presented at EULAR 2023 in Milan, Italy.
https://t.co/Xgt85l6WgQ https://t.co/jPcA2GSFdm
Dr. John Cush
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ACR Concerned with MedPAC’s Cutting Part B Reimbursement
ACR took issue with the orgs reco to Congress to keep a 6% add-on payment for the lowest-cost drugs, reduce the add-on payment for mid-to-high-level drugs, and add a payment cap for the $$$ drugs.
https://t.co/IwZO88QThb https://t.co/GHjDwbHCCo
Dr. John Cush
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FAAH and FAAH-OUT - genes involved in pain perception; could these be the target of future therapies? Interesting article in FORBES bout role of FAAH and FAAH-OUT in pain. https://t.co/8FNvkVZy5R https://t.co/8Ldywt2wvq
Dr. John Cush
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Higher Genetic Loads Linked to Worse Systemic Lupus
A study of a large SLE cohort shows by genomic analysis, that higher wGRS is associated with earlier SLE onset, higher anti–Sm antibody positivity, lupus nephritis and more diverse lupus manifestations.
https://t.co/L8ZZEgcfNM https://t.co/elwDtDuSjP
Dr. John Cush
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WATCH: Update on CAR T-Cell Therapy in SLE & Autoimmune Diseases
Dr. Peter Nash reporting from EULAR 2023 in Milan, Italy.
https://t.co/EpsPtwtJJt https://t.co/QxH8Pff6RS
Dr. John Cush
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275 early RA pts and after 2 years, 32% reported unacceptable pain (UP). Predictors of UP best seen at 3 mos FUV (not baseline) and included #Tender Jts (not swollen), overall pain, patient global assessment, and HAQ. https://t.co/Zlv3919Ucz https://t.co/1K1zPvhUYi
Dr. John Cush
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EULAR Offers Tips on Psoriasis Progression to PsA
Clinicians treating patients with psoriasis should be on the lookout for certain signs that joint involvement is likely to develop, according to a new "points to consider" from the EULAR.
https://t.co/eFsWJBmzCR https://t.co/slq58tWJG6
Dr. John Cush
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Biosimilars Match Biologic Originators in RA
A JAMA review shows that biosimilars of adalimumab, infliximab, and etanercept were associated w/clinically equivalent treatment effects compared with their ref biologics for treatment of RA.
https://t.co/EO22ThFL5C https://t.co/wlK0e2Cg5l
Dr. John Cush
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BIOSIMILARS (93 in EU, 40 in US) are approaching a tipping point with 8 new adalimumab biosimilars in 2023. Humira sales are down ~26% in 2023. Biosimilar sales expected - $129 billion in next 5 yrs, with estimated savings of $181 billion https://t.co/HMOYaSaIBQ https://t.co/6jOujr4JXQ
Dr. John Cush
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Time to Risk Stratify Methotrexate Lab Monitoring?
A longitudinal cohort analysis has developed a prognostic model that informs a risk stratified approach to monitoring blood tests during long term methotrexate (MTX) therapy.
https://t.co/AP89MAIlJM https://t.co/YpfWFCLF1z
Dr. John Cush
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Should we be reassured of JAK safety with new data?
Dr. Janet Pope discusses abstracts OP0133 and OP0132 at EULAR 2023 in Milan, Italy.
https://t.co/gxLJGHXwlm https://t.co/SgdGRJXBIi
Dr. John Cush
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Bimekizumab (Bimzelx) has been EMA approved to treat adults with active PsA & axial spondylarthritis in the EU. This dual IL-17 A/F inhibitor is approved to treat moderate -severe plaque psoriasis in the EU, Canada, UK & Japan; but not yet in USA https://t.co/DGczkgHtpZ https://t.co/TquFCuh4QG
Dr. John Cush
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Swedish registry study shows of 3629 children born to mothers with RA#, 70 (1.94%) were diagnosed with Autism Spectrum disorder (ASD). If RA was dx before delivery, an increased risk of ASD (HR = 1.43), especially for seronegative RA (HR = 1.61) https://t.co/fA6gzta5rx https://t.co/mGdzTqjEr7
Dr. John Cush
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RheumNow’s newly launched Poster Hall features sponsor-generated clinical trial posters designed to educate and inform. Check out our Poster Hall today!
https://t.co/opulSMICUf https://t.co/XtWePsWQCt
