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COVID-19 in Pregnant Rheumatic Women

d Jack Cush, MD

The Global Rheumatology Alliance (GRA) has studied the outcomes of women with rheumatic disease who were pregnant at the time of infection with coronavirus disease 2019 (COVID-19).

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2021 Rheumatology Year in Review

d Jack Cush, MD

Our top 10 list of advances, game-changers, worries and those better medical practices that evolved during 2021.

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Comorbidities Drive Risk of Severe Outcomes with COVID-19

d Jack Cush, MD

The current edition of the MMWR from the CDC shows that among those vaccinated against COVID-19, there is a low risk of severe outcomes (hospitalization and death); the highest risk is seen in those with multiple comorbidities.

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COVID Breakthrough Infections with Arthritis and HIV

d MedPage Today

Among immunocompromised individuals vaccinated against COVID-19, solid organ transplant recipients as well as those with HIV and rheumatoid arthritis (RA) were significantly more likely to experience breakthrough infections versus people without immune dysfunction, a retrospective study found.

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In Mouse Model of Lupus, when the gut microbiome of NZM2410 mice colonized w/ SFB, glomerulonephritis worsened & was assoc. w/ incr in TH17, MCP-1 and CXCL1, & more microbial abundance & biodiversity (dysbiosis) https://t.co/bLxrJZKTDZ

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NICE (UK) has recommended upadacitinib for use in active Psoriatic Arthritis, 15 mg qd +/- MTX, in pts not responding to DMARDS. UPA can now be used in England Wales and Scotland https://t.co/JFxMrgjrUe

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The global rheumatoid arthritis drugs market size was valued at $57,929 million in 2019, and is projected to reach $62,935 million by 2027. https://t.co/hQTDc0ajdN

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ICYMI: Comorbidities Drive Risk of Severe Outcomes with COVID-19 https://t.co/9GgfvgnMke https://t.co/JGHp0mVPpF

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ICYMI: Study of biologic/ts DMARD switching in 8,398 axial spondyloarthritis pts from 5 Nordic registries showed a low rate of multiple switches (refractory?) over 3 years; ≥3 DMARDs (8%), ≥4 (3%) & ≥ 5 (1%); more w/ women, comorbiditiy & psoriasis https://t.co/tc5D3Bwnnj

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ICYMI: Cosentyx (secukinumab) was FDA approved for use in pediatric psoriatic arthritis & enthesitis-related arthritis, based on results of the ph III JUNIPERA study. Dosing based on weight (SEC 75 mg sc if 15-50kg; SEC 150 mg sc if 50 kg or more) https://t.co/S6mQmwKT1X

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ICYMI: Clinical Practice Guidelines for Multisystem Inflammatory Syndrome in Children Multisystem inflammatory syndrome in children (MIS-C) is new and serious complication of COVID-19 that preferentially affects adolescents. Read more : https://t.co/OAPdLCxHgy https://t.co/0RnYKeg891

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ICYMI: New Onset Rheumatic Disorders with COVID-19 Infection The journal Cells has published a review of new rheumatic disorders following COVID-19 infection. Read more: https://t.co/X2DLznJynL https://t.co/wLCWt7gwgf

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ICYMI: Infectious mimics of #RA include viruses (Parvo B19, HBV, HCV, HIV, Chikungunya alphaviruses) mycobacterial infections (Poncet's dz, TB, leprosy), bacterial arthritis, brucellosis and Lyme disease. https://t.co/3FOydnsj1V

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In case you missed it… Autoantibody Associations in Systemic Sclerosis https://t.co/sOe4A8OzQp https://t.co/jjYBVH05Iy

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Register for RheumNow Live, March 19-20, 2022. You can attend RheumNow Live in person in Irving, Texas - or, the comfort of your own home or office. You can also receive CME credit! https://t.co/cb787PiX5v https://t.co/ChAqBRCh7c

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Drs. Jack Cush and the RheumNow Faculty Drs. David Liew, Swetha Ann Alexander, Meral El Ramahi, Mrinalini Dey and Robert Chao, discuss highlights from Day 2 at the ACR21 Virtual meeting. https://t.co/MZroMY2rrb https://t.co/2Ey1hG4mv6

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New Onset Rheumatic Disorders with COVID-19 Infection The journal Cells has published a review of new rheumatic disorders following COVID-19 infection. Read more: https://t.co/WdtNQWnGmk https://t.co/Fmoh1Wsvg4

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Risk of Cancer w/ IgG4-related disease (IgG4-RD)? A meta-analysis of 10 studies shows compared to gen population, IgG4-RD has a higher risk of overall cancer(SIR 2.57), esp pancreatic (SIR 4.1) & lymphoma (SIR 69.2); but not lung or gastric cancer https://t.co/EzgMXIdFcL

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MMWR (CDC) reports that In 2019, 12.3% and 10.0% of adults met fruit and vegetable intake recommendations. Fruit intake highest w/ Hispanics(16%), lowest in males (10%). Veggie intake highest ≥51 yrs (12%), lowest w/ low income (7%)https://t.co/fxQszBy7vO

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Clinical Practice Guidelines for Multisystem Inflammatory Syndrome in Children Multisystem inflammatory syndrome in children (MIS-C) is new and serious complication of COVID-19 that preferentially affects adolescents. Read more : https://t.co/3VXU7vEkb7 https://t.co/bWUseG9ogf

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