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Favorable Pregnancy Outcomes in Spondyloarthritis

Aug 16, 2022 4:02 pm

Pregnancy often occurs in women with axial spondyloarthritis (axSpA), and a recent cohort study suggests outcomes are generally better than what had been reported in the literature.

Data was collected from axSpA patients from 4 registries who were pregnant. This included a total of 332 pregnancies from 304 axSpA women (mean age 31 years; disease duration 5 years).  Recorded outcomes included:

  • 78% received pre-conception counselling (78.4%).
  • TNFi use - 53% before pregnancy; 27% in first and 21% in third trimester.
  • Pregnancy Outcomes
    • 99% live birth pregnancies resulted
    • 2.2% pre-eclampsia
    • 4.9% preterm birth
    • 3.1% low birth weight
    • 9.5% for small for gestational age.
    • 28% caesarean section deliveries (neonates); nearl half (47%) were emergencies

Activity was low throughout these pregnancies with a mean CRP of 4 mg/L before conception rising to 9.4 mg/L in 2nd trimester. The BASDAI was below 4 at all time-points.

These patients were well controlled, well treated and tightly managed at expert centers. Such is a formula for successful pregnancy outcomes in axSpA patients. 

The author has no conflicts of interest to disclose related to this subject

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