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Indications Awaiting (12.17.21)

d Jack Cush, MD

There's good news and bad news in rheumatology fellowship matching for 2022.  There's also new FDA approvals and indications, but a new serious safety warning has arisen from the CDC about the J&J COVID-19 vaccine. 

Dr. Jack Cush reviews the latest news, journal reports, regulatory approvals, plus 3 new cases from rheumatologists.

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CDC Panel Recommends mRNA COVID Vaccines Over J&J Vaccine

d Jack Cush, MD

The U.S.

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Cancer,cells

Certain Cancers Increased with Autoimmune Diseases

d Jack Cush, MD

Rheumatologists are well aware that inflammation and immune dysregulation are prime contributors to cancer risk, but do oncologists carry the same impressions? A large study from JAMA Oncology shows that patients with immune-mediated diseases (IMD) have an overall increased risk of cancer, especially in organ-specific immune-mediated diseases. 

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Gout pills injection

SGLT2 Inhibitors in Type 2 Diabetes Lowers Gout Risk

d Jack Cush, MD

A recent study of drugs used in type 2 diabetes (T2DM) shows that SGLT2 inhibitors have a lower risk for gout compared with those receiving DPP4 inhibitors.

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CDC Panel Recommends mRNA COVID Vaccines Over J&J Vaccine The CDC has recommended the two authorized mRNA COVID-19 vaccines over J&J adenovirus COVID-19 vaccine, primarily due to the rare reports of thrombosis with thrombocytopenia syndrome (TTS). https://t.co/qjZlzE7top https://t.co/UKsLbtRNv2

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Telemedicine? Surveys (patients=1340, MD=111) & interviews (pts= 31, MD= 29) April 2021 and July 2021. Results suggest pts and MDs prefer F2F over Telemedicine almost all categories. Some negatives may be due to the pandemic https://t.co/TdOORCfx6l

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Tofacitinib 1st JAK Inhibitor Approved for Ankylosing Spondylitis The FDA approved tofacitinib (Xeljanz, Xeljanz XR) for treating active ankylosing spondylitis in adults, Pfizer announced. https://t.co/NczbrBXBl7 https://t.co/l93OM86qaX

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UCB released results of BE MOBILE 2 Phase 3 study of bimekizumab, a dual IL-17A and F inhibitor, in active ankylosing spondylitis. Showing at wk 16 superiority of BIM over PBO in ASAS40, BASDAI, ASDAS, ASAS partial remission https://t.co/Jt8mpxUCv0 https://t.co/T5QpJu8n6r

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CV mortality with infection & inflammation studied using CDC database; From 1999 to 2018 CV mortality decreased in general population (40.9 to 30.6%) but increased w/ HCV (7.0 -10.2%) & HIV (1.9 to 6.7%); decreased in plateaud in IBD, PSO, RA, and SLE https://t.co/Oiv92xRs6W

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RESTORE trial: yet another failure for PRP injections for knee #OA. Study of 288 Knee oA over 50 years - knee pain scores of −2.1 vs −1.8 on an 11-point scale (range, 0-10) and no difference between PRP and PBO at 12 moshttps://bit.ly/3dZ5ebW

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SOBI has received a positive opinion by the EMA's CHMP on Kineret (anakinra) for the treatment of COVID-19 in adult patients with pneumonia requiring supplemental oxygen or at risk for progressing to severe respiratory failure. Final approval pending https://t.co/1bJYae38hw

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It has been a absolute honor to serve the rheum community. Your generous friendship and the ideas sparked on this account inspired me. It was a difficult decision, but yesterday was my last official day at @ACRheum. Thank you for 20+ years of pure goodness. https://t.co/sjAQcgQcSh
Donna Hoyne donna_hoyne ( View Tweet)
NRMP has released match results for adult Rheumatology programs. From a total of 125 programs, 120 filled & 98% of Rheum slots (266/272) filled. Rheum was one of few to fill >95% slots (also Allergy, cardiology, Endo, GI, Hem/Onc, Pulm/Critical Care https://t.co/7ASNKwB4ZS https://t.co/7fDrqG2WRM

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NRMP announced match results for Pediatrics & Specialties. Unfortunately 31% of positions are unfilled (40% programs unfilled). We need more Pediatric Rheumatologists!!! https://t.co/s0zPL7QhIG https://t.co/ufuuWb3rJc

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NEJM Clinical Images - Tongue Necrosis in Giant Cell Arteritis. 74-yoF w/ 3-day hx of HA and tongue swelling/pain, & blindness in the right eye. Tongue was ulcerated, R temporal artery thickened. ESR 42 CRP 169 mg/L. Read rest of story... https://t.co/Npc48trzk6 https://t.co/YfikSZmjWk

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Might Tofacitinib Reduce Malignancy Risk with Patients with RA? https://t.co/lrBwN6meQR https://t.co/cW2FEGbEaH

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Cochrane analysis of NSAIDs in acute #Gout - 28 trials, 3406 pts showed: - NSAIDs > PBO 50% pain reduction @24hrs, but = to PBO for AEs & W/D - nonselective NSAIDs = COX-2 inhib, but former has more AE & WD - PRED - NSAIDS, but pred has more AE & WD https://t.co/AemfID4RLN https://t.co/Ex1stFG9WG

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JAK Safety -- The Lowdown on Infection: Drs. Kevin Winthrop and Jonathan Kay https://t.co/6Um0la1yRi https://t.co/W4xHBxB2AV

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Juvenile Psoriatic Arthritis (JPsA) and Enthesitis-Related Arthritis (ERA)- Current Challenges and Future Outlook https://t.co/O6GENGGxKm

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Study of 408 men with inflammatory arthritis fathered 897 singleton pregnancies with 794 live births. Pregnancies conceived after the diagnosis of IA had higher rate of miscarriage (12.3 vs 7.5%, p = <0.05), even after adjusting for confounders (OR 2.03) https://t.co/Nq2lP0SXTL

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