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The drug talarozole – which increases retinoic acid – could be a promising new treatment for hand osteoarthritis.
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Undifferentiated arthritis (UA) is common in medical practice and many advocate early use of DMARDs; yet a recent study shows that despite DMARD use, UA patients do not fair well with this approach.
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The ACR/EULAR 2022 revised classification criteria for granulomatosis with polyangiitis (GPA) have been updated with performance characteristics and are validated for use in clinical research.
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Osteoarthritis is a common chronic condition that usually causes joint pain and can be severe enough to require knee and hip replacements.
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Mehta et al have published a full read review of managing interstitial lung disease (ILD) in patients with inflammatory myopathies, a heterogeneous group of syndromes connected by ILD and and increased morbidity and mortality risk.
Dr. John Cush
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Spanish SpA Registry (REGISPONSER) - 18.3% had psoriasis; w/ 3/4 of these (76%) having PSO before MSK Sxs. Pts w/ PSO before MSK Sxs had shorter dz duration, lower BMI, Less B27 & anterior uveitis, more dactylitis and ^risk PsA dx (78% vs 56%)
https://t.co/Kc1n4RVe3v
Dr. John Cush
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Nailfold Capillaroscopy doesnt have to be expensive: use handheld Carson Microbrite (~$10) 10x or 20 x handheld microscope (w/ KY gel) to evaluate #Raynauds #scleroderma https://t.co/aJ6K6JeVCp https://t.co/0aUBnqxhic https://t.co/54s66sWvyv #RWCS2022
#BestOf2022
Dr. John Cush
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Leflunomide versus azathioprine in lupus nephritis? Study of 215 bx proven LN given either LEF or AZA - Renal flares were equal (15.7% v 17.8%), as was time to flare (16 mo vs AZA 14 mo); 24-hr proteinuria, creatinine, C3 and C4 improved similarly.
https://t.co/fbzhuFT3lh
Dr. John Cush
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From the Hopkins Lupus cohort - Just one month of Prednisone 40 mg/d yields a FOUR fold increase in avascular necrosis risk #UTSWSLE2022 https://t.co/Kae2PMVgl7 https://t.co/XuhbkBwlCw
Dr. John Cush
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MTX side effects more prominent in PsA than RA pts. Study of 240 PsA & 86108 RA pts starting either MTX or TNFi. TNFi AE same betw PsA & RA, but MTX adverse greater in PsA (44.8% vs. 29.4%), especially N/V, abdominal pain, depression, tinnitus https://t.co/qpGYDguYBK https://t.co/KUNQrSBNO2
Dr. John Cush
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Cancer Risk with Scleroderma
Spanish Scleroderma Registry examined a large cohort of systemic sclerosis (SSc) patients showing an increased cancer risk, especially breast, lung, hematologic and colorectal cancer.
https://t.co/S3EHajMF9q
#BestOf2022 https://t.co/kV772Jef4V
Dr. John Cush
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#BestOf2022
Metanalysis of 7 studies shows that oral anticoagulants need not be discontinued for joint injections or aspiration. Only pts w/ hemorrhage after 5427 procedures, over 32-yrs. INR values of 3 bleeding cases was 1.9, 2.3, and 3.4. https://t.co/8e1zIhDTJt https://t.co/L4vIkWf2OL
Dr. John Cush
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Co-administration of MTX with Folic Acid on the same day did not reduce efficacy compared to FA application one day after MTX. (based on AIA was induced in female Lewis rats) https://t.co/uh78ZdsqgP https://t.co/j32q68DU0X
Dr. John Cush
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COVID-19 Vaccine Responses in Rheumatic Disease Patients
Nature Reviews Rheumatology features a review of three notable papers that address the impact of SARS-CoV-2 vaccination on people with inflammatory rheumatic disease.
https://t.co/R9UM3amPRR. https://t.co/WmHyVKdsxw
Dr. John Cush
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JAK Inhibitor Potential in Systemic Sclerosis-Associated ILD
The occurrence of interstitial lung disease (ILD) in Systemic sclerosis portends serious morbid and mortal outcomes for those affected.
https://t.co/I1TCG3AtaW https://t.co/T7r2VKBPhG
Dr. John Cush
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New download available-GCA and PMR New Drugs
https://t.co/m6ELSOLd4z. https://t.co/8a52dQ9wSk
Dr. John Cush
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Low dose steroids can negatively impact bone health
Dr. Janet Pope discusses abstract L01 presented at ACR22.
https://t.co/IbwnvCPszh https://t.co/bpswN5plNi
Dr. John Cush
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The First Head to Head trial in Axial SpA
Dr.Gensler discusses abstract L15 presented at #ACR22. L15: Effect of Secukinumab versus Adalimumab Biosimilar on Radiographic Progression in Patients with Radiographic AxSpA: A Randomized Phase IIIb Study
https://t.co/J0DT1yw0vQ https://t.co/kKhFQKAy6H
Dr. John Cush
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Practical Guidance for the Clinical Rheumatologist in Unplanned Pregnancies
Women of reproductive age comprise an overwhelming majority of patients with rheumatic and musculoskeletal disease.
https://t.co/x44GTLRtnT https://t.co/YlLgqeDRgP
Dr. John Cush
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2022 ACR/EULAR Giant Cell Arteritis Classification Criteria
Giant cell arteritis (GCA) has historically been a clinical diagnosis (visual loss, headache, jaw pain, scalp tenderness, etc) supported by labs and histopathology.
https://t.co/DN82rXco3N https://t.co/dpIixCFseT
