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alopecia,areata,bald,hairloss

Baricitinib Efficacy in Alopecia Areata

d Jack Cush, MD

The NEJM has published the results of the BRAVE-AA1 and BRAVE-AA2 trials, demonstrating that baricitinib is effective at regrowing hair in alopecia areata (AA) patients, thus paving the way for future regulatory approval for this difficult to treat disorder. 

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Lupus Worries (3-25-22)

d Jack Cush, MD

Dr. Jack Cush Reviews the news and journal reports from the past week in RheumNow.com.

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Comorbidity Drives Risk of Death in Gout Patients

d Jack Cush, MD

A study of men with gout from the US Veteran’s Health Administration (VHA) shows that excess mortality in gout could be attributed to comorbidities.

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CV,risk,MI,heart,cardiac

Stable Low Risk of Acute Coronary Syndrome in RA

d Jack Cush, MD

A Nordic multinational collaborative study examined the risk of acute coronary syndrome (ACS) in rheumatoid arthritis and found a less than 2 fold increased risk of ACS patients initiating biologic disease-modifying antirheumatic drugs (bDMARDs) with little risk variation with short-ter

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hospital,surgery

SLE Higher Risk of Postoperative Cardiac Events

d Jack Cush, MD

ACR Open Rheumatology reports that systemic lupus erythematosus (SLE) patients have a higher risk of postoperative major adverse cardiac events (MACE) that can be identified by common cardiac risk measures.

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Infection in lupus is suggested by very high CRP, PMN-lymph ratio (NLR) Plt-lymph ratio(PLR). Study of 104 hospitalized SLE found all very high w/ infx & Combined cutoffs of CRP >20 mg/L, NLR >3.5, PLR >151 had 87 sensitivity & 81% specificity for infx https://t.co/5SjFsrBiZp https://t.co/0Ipussd9fF

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ICYMI: Montreal General Hosp SLE cohort study of 489 SLE pts - 35% have Raynauds phenomena; RP in SLE assoc. w/ Female (OR 2.43), White (OR 1.85), CNS disease (OR 1.98), RNP Abs (OR 3.0); negatively assoc w/ hemolytic anemia & cellular casts https://t.co/5t3GL4jqrm https://t.co/gVVqccvtca

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ICYMI: Environmental Pollutants Ups Autoimmune Disease Risk An Italian environmental study shows that air pollution increases the risk of autoimmune diseases, in particular rheumatoid arthritis, CTDs and inflammatory bowel diseases (IBD). https://t.co/oKdgSZ2jAF https://t.co/WI7aShKR97

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New podcast available on Lupus worries. Download wherever you get your podcasts. https://t.co/gU1mmRXYUi https://t.co/54IDshqNYd

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ICYMI: Effect of Intraarticular Steroid Shots on Knee OA Outcomes In patients w/ OA of the knee, intra-articular injections of steroids didn’t increase rates of either disease progression or subsequent knee replacement surgery, researchers said. https://t.co/qinnfFLsGQ https://t.co/6859pSNNhL

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ICYMI: Drugs for Pregnancy Hopefuls A Young Woman has uncontrolled RA, but wants to get pregnant. What do you chose? https://t.co/Sunx8RWRfM https://t.co/hsFNhVfwHd

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ICYMI: Adalimumab Addition vs. Methotrexate Escalation in Psoriatic Arthritis https://t.co/q0uIjLrT3G https://t.co/ehgEUSrbPg

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ICYMI: Swedish study found 1774 systemic sclerosis (SSc) pts in 2015 w/ median age 65 yrs (84% women) = prevalence=22.7 per 100,000 . Incidence (2004-2015) was 11.9 per 1,000,000 PYs - incidence remained stable; F were 5x more common than M. https://t.co/NPZUg4CEjA https://t.co/V3H381KpHU

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Ask Cush Anything! Have a rheumatology question or case for Dr. Cush? Submit it here and we may feature it on an upcoming podcast. https://t.co/KgPIeScthr https://t.co/nk4re9mlcH

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High disease trajectory despite disease control (^HAQ > DAS28) in RA is more likely with higher pain, fatigue & depression. 10 ys study of 2500 RA pts from NOAR, ESPOIR, ERAN) https://t.co/mrB7fog6PD https://t.co/tqm3LPkOdM

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98 axial SpA women with 335 pregnancies (279 live births) shows preterm birth ( (12.5 v 5.2%), preeclampsia(6.8 v 2.8%) & LBW (8.2 v 2.9%) more prevalent in axSpA, possibly due to incr disease activity during pregnancy & postpartum https://t.co/Bp8QjBXg2K https://t.co/j0xKVvSPIH

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TENS does not work! Multi-centre, trial in 220 active Knee OA pts pitted TENS vs placebo TENS for 3 Wks. Using WOMAC pain scores there was no difference between TENS and placebo TENS (mean diff -0.06; P=0.74). No diff in AE or 2ndary outcomes https://t.co/4Aw9s1zfBQ https://t.co/gwdK6nbKLB

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Poor Outcomes in Lupus Patients Not at Target A prospective, longitudinal SLE cohort study examined outcomes and showed that failure to control SLE was common/associated with poorer outcomes including organ damage, glucocorticoid exposure, and more. https://t.co/wQMmPgbmWF https://t.co/ROeZU56cfy

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Effect of Intraarticular Steroid Shots on Knee OA Outcomes In patients with osteoarthritis of the knee, intra-articular injections of steroids did not increase rates of either disease progression or subsequent knee replacement surgery, researchers said. https://t.co/KlNj1GABlb https://t.co/2npPTNSlSA

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Having the MUC5B promoter variant increases odds of RA-ILD w/ earlier onset in RA, esp w/ older age of RA onset. Mass Gen Biobank study of 1,005 RA pts; MUC5B found in 15% w/ incr risk of RA-ILD (OR 3.34) & RA onset after 55 yrs (OR 1.52) https://t.co/5odVWnpuxo https://t.co/zeKxADTSBZ

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