Several studies have suggested that lithium chloride exhibits significant chondroprotective effects on cartilage degradation (in animal models) in response to inflammatory cytokines.

Defects in protein citrullination and its consequences in patients with RA have been studied widely in the recent decade. It appears that autoantibodies, including those against citrullinated proteins, are of diagnostic and prognostic relevance.

Increased sodium intake has been shown to increase Th17 cell activity, and in animal models high-salt diets have been shown to drive IL-23-dependent TH17 cells to cause experimental allergic encephalomyelitis (citation source (http://url.ie/z238). I

Regenerative medicine and the use of bone marrow stromal cells (or mesenchymal stem cells - MSC) is controversial in many areas of medicine, including osteoarthritis. MSC use is at a very early stage in orthopedic research, but has been investigated in osteoarthritis of the kn

A prospective cohort of 331 patients tested for anti-adalimumab (n=160) and anti-etanercept (n-171) antibodies after initiation of their TNF inhibitor therapy.

1998 marked the introduction of citrulline as a unique target in the pathogenesis of rheumatoid arthritis. The hallmark article by Schellekens et al in the Journal of Clinical Investigation has since been cited over 500 times.  Dr.

The danger model was proposed by Matzinger as an alternative (or complement) to the traditional self-non-self (SNS) model of autoimmunity.

The defining triad of Blau's syndrome includes granulomatous polyarthritis, dermatitis and uveitis.  This rare, monogenic, autosomal dominant disorder stems from a "gain in function" mutation of the pattern recognition receptor NOD2.

In the mid-1990s, our Rheumatology Division at the University of Texas Southwestern Medical School became involved with an early trial of a brand new TNF inhibitor.

The HLA-DRB1 haplotype is a known risk factor for RA.