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Serious Infection Risk High in Patients With Lupus

d MedPage Today

Patients with systemic lupus erythematosus (SLE) had two to four times higher risk for serious infection requiring hospitalization, a nationwide Swedish study found.

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RheumNow Podcast – Do More DMARDs Mean More Switching? (9.17.2021)

d Jack Cush, MD

Smartphones and diet; COVID-19 and the numbers - reassuring or not, and what about masks?; and do more drugs mean more switching, less persistence, and patient adherence goes up...or down? All this and more news and journal reports in this week's episode.

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Patients with systemic lupus erythematosus (SLE) had two to four times higher risk for serious infection requiring hospitalization, a nationwide Swedish study found. https://t.co/ilkqTtZjVL #RheumNow https://t.co/hzcqlNUF66

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Dr. John Cush RheumNow ( View Tweet)
ICYMI: American College of OBs & GYNS and the Society for Maternal-Fetal Medicine both enthusiastically endorse COVID Vaccination of pregnant women, given the delta variant, low vax rates in Preg women and poor COVID outcomes in preg. https://t.co/AmP5eOEgr3 #RheumNow https://t.co/wXeT1KDCrJ

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Dr. John Cush RheumNow ( View Tweet)
ICYMI: Gitelman syndrome (GS) is common salt-wasting genetic tubulopathy causing hypokalaemia and hypomagnesemia. Chondrocalcinosis (CC) is a frequent feature of GS. Study of 57 GS pts - 79% had CC, esp in Cx spine, Knee & wrist. https://t.co/ctEAQq1zzL #RheumNow

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Dr. John Cush RheumNow ( View Tweet)

In case you missed it… Breakthrough COVID infection. Breakthrough brilliance in a KOL A must read from Len Calabrese https://t.co/2Ljzau5nBG #RheumNow

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Dr. John Cush RheumNow ( View Tweet)

We've got a new podcast available for download! Dr Jack Cush reviews the news and journal reports and takes cases and questions from rheumatologists. https://t.co/ErJJ5XL8NA #RheumTwitter #RheumNow #medtwitter https://t.co/tqyVNyNYa4

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Dr. John Cush RheumNow ( View Tweet)
ICYMI: Population study shows risk of H. Zoster in adults to be high among bDMARD and CTX, also increased w/ AZA and HCQ but not MTX SSZ or LEF users. Data from 254065, 1,826311 Pt-Yrs F/U, 6295 new DMARD users, 17024 incident HZ https://t.co/1TeOAWN9LB #RheumNow

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Dr. John Cush RheumNow ( View Tweet)

ICYMI: Probenecid, an OAT3 inhibitor, has inhibitory effects on RNA viruses (influenza, RSV) & decreases ACE2 expression. May have utility in COVID-19 as it was shown to inhibit SARS-CoV-2 replication in animal models https://t.co/MClSjpqpSa #RheumNow

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Dr. John Cush RheumNow ( View Tweet)

Do More DMARDs Mean More Switching? Tune in to this week's podcast to find out. https://t.co/ErJJ5XL8NA #RheumNow #RheumTwitter #medtwitter https://t.co/5Ufk0XQbmb

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Dr. John Cush RheumNow ( View Tweet)
Looking for Rx updates? We’ve got them for you. https://t.co/FOfqUvZ8nx

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Dr. John Cush RheumNow ( View Tweet)

ACR Responds to 2022 Medicare Physician Fee Schedule Proposed Rule Read more: https://t.co/SVGhfhp6Fg #RheumNow #RheumTwitter #medtwitter https://t.co/g46wYCdary

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Dr. John Cush RheumNow ( View Tweet)
Breakthrough COVID infection. Breakthrough brilliance in a KOL A must read from Len Calabrese https://t.co/2Ljzau5nBG

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Dr. John Cush RheumNow ( View Tweet)

A retrospective records review of patients with periodic fever syndromes (PFS) receiving IL-1 inhibitor treatment with canakinumab (CAN), shows CAN to be effective and safe in a variety of PFS patients. https://t.co/4lqMhE6ikx #RheumNow #RheumTwitter #medtwitter https://t.co/yThiwJhcwO

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Dr. John Cush RheumNow ( View Tweet)
32 RA pts; each w/ 2 stool samples >6 mos apart - stool metagenome sequencing stool samples and pt activity assessed. Microbiome most influenced by age, followed by those achieving minimum clinically important improvement https://t.co/unaEOOuP34

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Dr. John Cush RheumNow ( View Tweet)

Gitelman syndrome (GS) is common salt-wasting genetic tubulopathy causing hypokalaemia and hypomagnesemia. Chondrocalcinosis (CC) is a frequent feature of GS. Study of 57 GS pts - 79% had CC, esp in Cx spine, Knee & wrist. https://t.co/ctEAQq1zzL

Links:

Dr. John Cush RheumNow ( View Tweet)

Another non stellar result for remdesivir Remdesivir plus standard of care versus standard of care alone for the treatment of patients admitted to hospital with COVID-19 (DisCoVeRy): P3, randomised, controlled, open-label trial ⁦@TheLancetInfDis⁩ https://t.co/kNSNj9RM4K

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Dr Philip Robinson philipcrobinson ( View Tweet)

#ACR21 abstracts now online! NOTE: To coincide with virtual meeting early access, information that goes beyond that contained in the abstract is under embargo until Nov. 1 at 10 AM ET. Browse → https://t.co/o0fpZCHZLC https://t.co/SaNrNQPgau

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American College of Rheumatology ACRheum ( View Tweet)
#ClinicalPearl Two risks for developing #psoriatic arthritis. Scalp involvement and nail involvement. Yes the patient has PsA https://t.co/sG4DueDtVy
Janet Pope Janetbirdope ( View Tweet)
American College of OBs & GYNS and the Society for Maternal-Fetal Medicine both enthusiastically endorse COVID Vaccination of pregnant women, given the delta variant, low vax rates in Preg women and poor COVID outcomes in preg. https://t.co/AmP5eOEgr3

Links:

Dr. John Cush RheumNow ( View Tweet)

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