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Frequency and Anatomic Distribution of MRI Lesions in the Sacroiliac Joints of Healthy Subjects and Patients with Spondyloarthritis. Dr Hecquet. #ACR20 @RheumNow BME was seen in 65% patients with Spa and in 20% without spondyloarthritis predominantly in the antero-middle quadrant https://t.co/OUYz2FQ5Yp
Sole RetamozoSole ( View Tweet)
Accdg to this study, no association was found between IFN levels and cognitive function in SLE pts (even after considering factors like SLE dse duration)
Interesting! @RheumNow #ACR20 abs1788 @ZahiTouma https://t.co/F4j8H1CWJ9
sheila RHEUMarampa ( View Tweet)
Abst#L01. Pt is on MTX/ADA for RA and asks you about their COVID risk. What do you counsel your patient? #ACR20 @RheumNow.
Eric Dein ejdein1 ( View Tweet)
#osteoarthritis Rx with #tanezumab - analgesic or DMOAD? RCT in knee OA of 3021 pts & only 1312 completed Rx. Tanezumab > improvement in pain v NSAIDs but NO diff in MCII and pt acceptable symptoms (PASS) over time #ACR20 #ACRbest abstr#1641 @RheumNow @CRASCRRheum https://t.co/x75ncz16uP
Janet Pope Janetbirdope ( View Tweet)
ACR20 - Day 2 Report
Saturday was the day 2 with many posters and live sessions at the 2020 Virtual ACR/ARP meeting. Here are a few of my highlights from day two:
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Poll results are in! Most would like to wait for a phase III before prescribing MMF with pegloticase in refractory gout. @RheumNow #ACR20 https://t.co/45MpFliDkE
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
Herpes Zoster Events with Anifrolumab in Patients with Active SLE: An Integrated Analysis of Phase 2 and Phase 3 Trials https://t.co/70oOHXihFb #SLE #zoster x 4-5 times increase in zoster
Peter Nash drpnash ( View Tweet)
How do we dose maintenance rituximab in AAV to optimise B cell depletion but minimise hypogammaglob?
Drug levels may be the answer. In this cohort (n=61)
trough >550ng/mL: all B cell depleted
>1000ng/mL: all got hypogammaglob
very interesting concept!
#ACR20 ABST1438 @RheumNow https://t.co/0pcl0BW2Tv
David Liew drdavidliew ( View Tweet)
Data from BIOBADASER 3 showed that there was a ⬇ in the incidence of S. pneumonia-related infxns in RA pts on b/tsDMARD after receiving the stepwise combined vax scheme (conj+PS) @RheumNow #ACR20 abs1465 #VaccinesWork https://t.co/KlestmKfaO
sheila RHEUMarampa ( View Tweet)
Interim analysis of the RELIANCE registry studying effect of canakinumab (CAN) in 80 patients w/ febrile CAPS. Efficacy of CAN assessed w/ AIDA (inflam index) showing ~70% were in low activity (<9) @ACR20 Abstr#1479 https://t.co/UC2eJbpVLM https://t.co/M71s8gXZY9
Dr. John Cush RheumNow ( View Tweet)
1yr results using anti-IL-23 Guselkumab shows the same ACR 20/50/70 responses regardless of prior TNF inhibitor failure. #ACR20 #Abstr#1344 https://t.co/OvgJ53wwmU https://t.co/JdajDONWap
Dr. John Cush RheumNow ( View Tweet)
Study of 351 SLE patients from Leiden shows that SLE with Neuropsychatric disease do not have a higher mortality than lupus without CNS disease; but do have higher mortality than gen. population #ACR20 Abstr#1264 https://t.co/CmBjfUj1Ur https://t.co/WYZQDaI4yt
Dr. John Cush RheumNow ( View Tweet)
ACR/AF JIA guidelines presented @ACR20:
👉Initiate DMARD early over NSAID monotherapy
👉Use SQ MTX> oral MTX > SSZ/LEF
👉add biologic preferred over triple DMARD
👉DON'T use chronic low dose steroids
👉combo biologic+DMARD > biologic monoRx
https://t.co/lwoFSTuV91
@rheumnow https://t.co/wzh2LCS0dN
k dao KDAO2011 ( View Tweet)
Trivia from John Stone's pearls talk: Which is the biggest risk factor for disease flare in GCA? (All are statistically signif RFs). #ACR20 @RheumNow
Eric Dein ejdein1 ( View Tweet)
John Stone: "The HISTORY is the Rheumatologist's scalpel." TA bx is not gold standard in diagnosis, as not fully sensitive. @RheumNow #ACR20.
Eric Dein ejdein1 ( View Tweet)
Abatacept in IgG4-RD. Plausible, but does it work?
Pilot n=10 @MGHrheumatology
ABA +<4w PNL
Some hit, some miss - but mechanistic correlates of response: Tfh2, unswitched memory B cells.
Exploring new options (w real benefit) very welcome in IgG4-RD!
#ACR20 ABST1480 @RheumNow https://t.co/0saS941Lga
David Liew drdavidliew ( View Tweet)
#ACR20 Dr. M. Crow on Lupus #StateofArtLecture reviews treatment of SLE:
1. HCQ is the foundation of Rx
2. keep pred <7.5mg/day
3. belimumab works better when given early in disease (<2 yrs)
4. combination Rx may be needed
@rheumnow https://t.co/6zh1xkLXgN
k dao KDAO2011 ( View Tweet)
Both fat mass and fat free mass have an impact on the response to bDMARDs after 6 months of treatment in AS pts. No tx response changes w/ skeletal muscle mass, visceral fat as well as water components. #ABS1376 #ACR20 @RheumNow https://t.co/oIdE8qvJPp https://t.co/wlXFf8esey
Dr. Rachel Tate uptoTate ( View Tweet)
5yr DESIR cohort data estimated incidence rate of uveitis at 1.3/100p-y; over five years, uveitis was associated w/ dactylitis, biologic and sacroiliac MRI inflammation. #ABS1304 #ACR20 @RheumNow https://t.co/qmXlY7PmBB
Dr. Rachel Tate uptoTate ( View Tweet)
Important thoughts- how do we actually use the biologics in practice for the rare diseases that do not have many FDA approved options? @RheumNow #ACR20 abstract 1429 https://t.co/SsYC1kF5uv
alexa meara lexmeara ( View Tweet)