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TNF Inhibitors or non-TNF Biologics - First Best Choice?

d Jack Cush, MD

Prospective observational findings from the CORRONA registry of rheumatoid arthritis (RA) patients compared clinical outcomes between initial aggressive therapy using either a tumour necrosis factor inhibitor (TNFi) or a non-TNFi (biological disease-modifying antirheumatic drugs (bDMARDs) and tar

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FDA Warning on NSAIDs in Pregnancy

d FDA

The U.S. Food and Drug Administration announced today in a Drug Safety Communication that it is requiring labeling changes for nonsteroidal anti-inflammatory drugs (NSAIDs).

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RheumNow Podcast – Good Time Charlie…. (10.16.20)

d Jack Cush, MD

Dr. Jack Cush sings the news and journal reports from the past week on RheumNow.com.

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Abatacept vs. Upadacitinib in Biologic Refractory Rheumatoid Arthritis

d Jack Cush, MD

NEJM reports the results of the SELECT-Choice trial, a head to head study of upadacitinib (UPA) and abatacept (ABA) in biologic refractory rheumatoid arthritis (RA); 12 weeks results showed UPA was significantly more clinically effective than ABA using a DAS28-CRP remission, but ABA had fewer safety signals and serious adverse events.

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ICI Arthritis Tied to Cancer Progression

d

Cancer patients treated with immune checkpoint inhibitors (ICI) who develop severe arthritis may be at risk for progression of the malignancy, a single-center study suggested.

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COVID Transmission from Young to Old

d Jack Cush, MD

The CDC has analyzed temporal trends in percent positivity by age group in COVID-19 hotspot counties before and after their identification as hotspots.

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Tofacitinib and Thromboembolic Risk

d Jack Cush, MD

Mease and colleagues have reviewed the tofacitinib drug development and clinical trial data, finding the risk of venous (VTE) and arterial thromboembolism (ATE) to be low and augmented in patients with baseline cardiovascular abd VTE risk factors and those taking higher doses of tofacitinib (10 m

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QD Clinics - Vignette Lessons from Rheum Clinic. Week 2: choosing IL-1 inhibitors, burnt out RA or not RA, trigger fingers, peripheral SpA, Gout or not? Listen on iTunes https://t.co/FHJv01Sb3a or on Android https://t.co/V488PY9lIo

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Dr. John Cush RheumNow ( View Tweet)

Congratulations to Carlos J. Lozada, MD, recipient of the 2020 Distinguished Fellowship Program Director Award! @UMiamiHealth #ACR20 https://t.co/OsiChNSbjn
American College of Rheumatology ACRheum ( View Tweet)
Looking forward to Cool Comedy Hot Cuisine with @bobsaget tomorrow evening - supporting #scleroderma research. This year the event is online - join us wherever you are! @srfcure https://t.co/2iuRKOKk3J

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Victoria Shanmugam VickiShanmugam ( View Tweet)

(Ethic)Efficacy of tocilizumab in patients with hand osteoarthritis: double blind, randomised, placebo-controlled, multicentre trial https://t.co/7k7p6HJ4Ni #tocilizumab #OAhands another one bites the dust!

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Peter Nash drpnash ( View Tweet)

SELECT CHOICE, H2H study of UPA vs ABA in TNF-IR RA pts; UPA had better DAS28-CRP & ABA had better Safety outcomes; Which would you use?

Dr. John Cush RheumNow ( View Tweet)

QD Clinics - Vignette Lessons from Rheum Clinic - Compilation on No Shows, Delays in SpA Dx, & when patients bail out on DMARD therapy. Listen on iTunes https://t.co/FHJv01AAbC on on Android> https://t.co/i8icH8AS9m

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Dr. John Cush RheumNow ( View Tweet)

Pre Print of UK research suggests biomarkers for Severe COVID-19 includes markers of myeloid or endothelial activation; such as D-dimer, EN-RAGE, CXCL10, GM-CSF, IL-6, TNF-α, IL-2, GDF-15, G-CSF, S100A12, https://t.co/Yv6yM4DYmp

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Dr. John Cush RheumNow ( View Tweet)

259 SLE patients followed an 80% were in lupus low disease activity state (LLDAS); 82% in remission; 19% w/ active dz. 56 pst in subjective Low activity (SLQ<6) compared to SLAQ>6, latter had more arthritis, fibromyalgia and took steroids https://t.co/IdeSNlaEOG

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Dr. John Cush RheumNow ( View Tweet)

Juvenile localized scleroderma was Rx w/ MTX or MMF (in MTX refractory) and compared retrospectively. Facial linear scler. more likely in MTX pts and MMF pts had pansclerotic morphea or mixed subtype. Outcomes were same at 9.4 yrs: inactive in 100% & 91% https://t.co/2X9SpqeLwx

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Dr. John Cush RheumNow ( View Tweet)

EUSTAR study of ILD in systemic sclerosis: 826 pts with SSc-ILD finds 27% with progressive ILD (mod-severe FVC decline >5-10%) over 12 mos. Predictive factors for FVC decline over 5 yrs were male sex, higher mRSS skin score and reflux/dysphagia symptoms. https://t.co/lLd2FrMIkx

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Dr. John Cush RheumNow ( View Tweet)

@MattieRheumMD @News_CRA @statnews People are being crushed by co-pays- rheumatology patients' co-pays doubled to $1000 last year - and medical staff are wasting much time on paperwork. Plus, the @Aetna @CVSHealth merger caused prior auth meltdown in many. (Intentional?) Rebate system must go! ASK STAKEHOLDERS.

Angus Worthing MD AngusWorthing ( View Tweet)

There have been many cases of Kawasaki vasculitis in kids ith COVID-19; now Lg vessel vasculitis in 79 yo Japanese man w/ COVID-19 pneumonia, CRP 17.7 mg/dL, spiking fevers and CTA and FDG-PET evid of aortic and LVV, neg ANCA, nl IgG4, but was HLA-DR4+. https://t.co/UpL4Z1qK2p

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Dr. John Cush RheumNow ( View Tweet)

Observational study of 123 Spanish rheumatic dz pts w/ COVID-19, finds 54 hospitalized. Admitted pts were 69.7 yrs, and 22% died. Admission was assoc w/ older age, autoimmune dz (vs inflammatory arthritis; OR: 3.55), but not DMARD Rx. https://t.co/UWNyhOKbvF

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Dr. John Cush RheumNow ( View Tweet)

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