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Spondyloarthritis at ACR Convergence 2020

Antoni Chan, MD, PhD

There are some really interesting poster and abstract presentations on spondyloarthritis at the ACR Convergence 2020. I’ll be covering these topics, and discussing select individual posters and abstracts during this meeting. 

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ACR 2020 Your Way - Get Your Topic Emails

Jack Cush, MD

ACR is but a few days away; the question is: how will you tackle this virtual meeting? RheumNow has created several options for learning the way you want to. First is to feed your need. Are you a lupologist? A gout maven? A Spondylitis sleuth? A drug safety wannabe?

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SPARTAN ACR20 Recommendations on Spondyloarthritis

Jack Cush, MD

SPARTAN has compiled a list of presentations and sessions worth seeing if you are interested in ankylosing spondylitis, spondyloarthritis and related disorders.

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US Differs from Worldwide Drug Reimbursements

Jack Cush, MD

"The US has nearly 4.5% of the world’s population but accounts for more than 40% of global drug spending" reports JAMA Internal Medicine.  US drug prices are nearly double those of Australia, Canada, and the United Kingdom, and the US spends twice as much on retail and nonretai

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RheumNow Podcast – ACR 20 is Coming to Town (10.30.20)

Jack Cush, MD

Dr Jack Cush overviews the RheumNow commitment, upcoming bonus coverage of ACR20 and the good news and journal reports from the past week on RheumNow.com

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RheumNow Podcast – Bad Disease & Bad Outcomes (10.9.20)

Jack Cush, MD

Dr. Jack Cush Reviews the news and journal articles from the past week on RheumNow.com.

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RheumNow Podcast – Function Follows Form (10.2.20)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com. Regulatory approvals, update on global rheumatology alliance, smoking and psoriasis, gabapentin let down and defining difficult RA.

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CXCR3 and Restricted T Cells in Psoriatic Arthritis Inflammation

Jack Cush, MD

Research from Oxford University suggests a potential pathogenic role for the chemokine CXCR3 and clonally restricted CD8+ T cells in the pathogenesis of psoriatic arthritis (PsA) based studies of PsA synovial fluid samples obtained by arthrocentesis from 11 patients with large-joint oligo Ps

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ACR 2020 Reproductive Guidelines - Medication Use with Pregnancy

Jack Cush, MD

The American College of Rheumatology (ACR) has published guidelines to manage reproductive health issues in rheumatic disease (RMD) patients before, during and after pregnancy.

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Study of 55 SpA patients with axial disease. 31% had high risk of falls (by survey) and 25% recalled having at least one fall in the last years. Risk higher w/ activity and adv disease. Pts w/ falls had lower quality of life. https://t.co/yu6mP6sxth

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Dr. John Cush RheumNow ( View Tweet)

QD Clinics - Vignette Lessons from Rheum Clinic. Week 2: choosing IL-1 inhibitors, burnt out RA or not RA, trigger fingers, peripheral SpA, Gout or not? Listen on iTunes https://t.co/FHJv01Sb3a or on Android https://t.co/V488PY9lIo

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Dr. John Cush RheumNow ( View Tweet)

Nonradiographic axial spondyloarthritis= meeting axSpA criteria without Xray sacroiliitis. Swiss study compared women & men w nr-axSpA. Women had a longer Dx delay, higher Dz activity & enthesitis, less B27+ & signif lower TNFi resp rate (OR 0.19) vs Men https://t.co/ykAHfimOd5

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Dr. John Cush RheumNow ( View Tweet)

The RheumNow Podcast is up - Bad Disease & Bad Outcomes. COVID consequences, TNFi Switching in SpA, psychosis in lupus? Watch it here> https://t.co/ced3cKg5eB or listent to podcast on iTunes> https://t.co/FHJv01AAbC or SoundCloud> https://t.co/e4nWr3wECz

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Dr. John Cush RheumNow ( View Tweet)

Study of 193 Axial SpA pts with TNF inhibitor switching shows, using stringent outcome measures (ASDAS-ID) shows odds of responding to 2nd TNFi best w/ secondary TNFi failure (OR 7.3) or adverse events (OR 9.1), compared to primary TNFi failure. https://t.co/kpDelzBYRe

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Dr. John Cush RheumNow ( View Tweet)

How pregnancy impacts nr-axSpA disease activity can vary from one woman to another, according to Eric Ruderman, MD, “I’ve had some patients who are better during pregnancy, and some who aren’t,” says Dr. Ruderman. Learn more about pregnancy and nr-axSpA: https://t.co/mC6YcG5lIx

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NM Rheumatology NM_Rheumatology ( View Tweet)

Among 406 axial SpA patients in the DESIR Cohort smoking was associated with MRI‐SI joint after 5 years of axial SpA patients and only in blue‐collar job or low education levels; suggesting a possible role for mechanical stress axial SpA. https://t.co/fcDjesdF8K

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Dr. John Cush RheumNow ( View Tweet)

Swiss cohort of 666 axSpA, RA & PsA pts seen before, during & after COVID; consults dropped 52%, remote visits increased 129%, & non-compliance slightly increased during COVID (axSpA 20% vs 13% before, p=0.003); but no incr in flares(<15%) or Dz activity https://t.co/lWb7WCwGbN

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Dr. John Cush RheumNow ( View Tweet)

ASSERT looked at ankylosing spondylitis (AS) pts treated with infliximab (n = 16) or placebo (n = 7). Infliximab was shown to reduce depression & depressive symptoms by improving AS disease Sxs. There was no link between CRP inflammation & depression https://t.co/oC5rQP2Jec

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Dr. John Cush RheumNow ( View Tweet)

Study of early axSpA from the DESIR cohort looked at MRIs of the SI joint/spine @baseline, 2 & 5 yrs; showed that bone marrow edema pn MRI‐SIJ and ‐spine at baseline predicted of ‐year damage pm MRI‐SIJ [OR=4.2] and MRI‐spine [OR=10.7] https://t.co/3PAJ5Zt4Pp

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Dr. John Cush RheumNow ( View Tweet)

Systematic literature review of the incidence of SpA subtypes: psoriatic arthritis overall IR of 9.7 per 100.000 PYs; AS overall IR of 4.8/100kPY, and reactive arthritis overall IR estimate of 3.4/100KPY. Little on undifferentiated spondyloarthritis https://t.co/U8yqk30cWb

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Dr. John Cush RheumNow ( View Tweet)

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