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IL-1 Inhibition Alters Arthroplasty Rates

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d Jack Cush, MD

Oct 07, 2020

A subanalysis of the CANTOS trial suggests that inhibition of interleukin-1β (IL-1β) can reduce rates of incident hip or knee replacement (THR/TKR) surgeries.

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Fractures from Delays in Denosumab Reinfusions

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d Jack Cush, MD

Oct 07, 2020

Denosumab is effective in osteoporosis when used on schedue, but research suggests that discontinuation leads to rapid reversal of effect; a new observational study has shown that delays in denosumab administration of more than 16 weeks results in an increased vertebral fracture risk, according t

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Oral Dysbiosis May Antedate Rheumatoid Arthritis

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d Jack Cush, MD

Oct 06, 2020

A study of oral microbiome in anti-cyclic citrullinated peptide (anti-CCP) positive at-risk individuals without synovitis (CCP+at risk) shows dysbiotic subgingival microbiomes and increased abundance of P. gingivalis compared with controls.

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Systemic Steroids Reduce Mortality in COVID-19

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d Jack Cush, MD

Oct 06, 2020

JAMA Internal Medicine reports an analysis of COVID-19 clinical trials showing that critically ill patients with COVID-19 treated with systemic corticosteroids have an overall lower mortality rate.

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2020 Nobel Prize in Medicine Goes to the Discovery of Hepatitis C

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d Jack Cush, MD

Oct 05, 2020

The Nobel Assembly at Karolinska Institutet has awarded the 2020 Nobel Prize in Physiology or Medicine jointly to Harvey J. Alter, Michael Houghton and Charles M. Rice for the discovery of Hepatitis C virus. These three scientists made a decisive contribution to the fight against blood-borne hepatitis C, a major global health problem that causes cirrhosis and liver cancer in people around the world.

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How pregnancy impacts nr-axSpA disease activity can vary from one woman to another, according to Eric Ruderman, MD, “I’ve had some patients who are better during pregnancy, and some who aren’t,” says Dr. Ruderman. Learn more about pregnancy and nr-axSpA: https://t.co/mC6YcG5lIx

Links:

Pregnancy and nr-axSpA | Everyday Health

NM Rheumatology NM_Rheumatology ( View Tweet)

Oct 06, 2020

To quash the virus, the immune system unleashes an arsenal. Sometimes these weapons turn inward and destroy healthy tissues. Combatting this friendly fire has become as crucial a part of the Covid-19 treatment strategy as subduing the virus itself. https://t.co/FrxVfSleEH

Links:

https://nyti.ms/2GJZjd2

NYT Health NYTHealth ( View Tweet)

Oct 06, 2020

The AWIR San Diego, CA Virtual Summit CME Accredited : Worth 3.0 CEU Credits™ October 11th | Register Now: https://t.co/4vSqD0bxpk Join us on October 11th as we discuss Spondyloarthritis & the Spine, Telehealth regulatory updates, and more! For MD, NP, PA & PharmD Health Prof. https://t.co/QLXVJYjTD2

Links:

AWIR Summit- San Diego

WOMEN IN RHEUM AWIRGROUP ( View Tweet)

Oct 06, 2020

https://t.co/EJD3z6ejkc

Dr. Dinesh Khanna sclerodermaUM ( View Tweet)

Oct 06, 2020

1) If you are have diffuse scleroderma and have previously participated in a clinical trial, we need your help! You will be asked to watch video tutorial and answer a survey which will take you 20 minutes to complete. the study is supported by @WeAreSRUK @scleroderma @srfcure

Dr. Dinesh Khanna sclerodermaUM ( View Tweet)

Oct 06, 2020

Incredible lecture on the highest of therapeutics for rheumatoid arthritis by @BrighamWomens Dr Michael Weinblatt. Love this screen shot of A to Z for therapies prior to the methotrexate era. Z=Zero therapy (do nothing). Incredible advances since then! https://t.co/AOIMBJiulo

Jeff Sparks jeffsparks ( View Tweet)

Oct 06, 2020

Classic bony erosion of gout is a punched-out, lytic lesion w/ a sclerotic margin & overhanging edge -- called a G sign, rat-bite erosion or the Martel sign, named after famed U MI radiologist Dr. William Martel who 1st described this gouty erosion in 1968 https://t.co/WJJUnjnnfl

Links:

https://bit.ly/3cZEd6O

Dr. John Cush RheumNow ( View Tweet)

Oct 06, 2020

European collaborative study of eosinophilic granulomatosis with polyangiitis (EGPA) Rx w/ RTX, mepolizumab or omalizumab (OMA). MEP > RTX > OMA. Mepolizumab was highly effective in GC‐dependent asthma. https://t.co/fi8pjnJO03

Links:

https://bit.ly/3iwgufJ

Dr. John Cush RheumNow ( View Tweet)

Oct 06, 2020

Swedish population study of psoriasis pts Rx w/ secukinumab (848) or ustekinumab (1107) showed slightly more respiratory infx & UTI (HR 1.22), w/ no difference in hospital treated severe respiratory, UTI (HR 0.96) or candidiasis (HR 1.80) https://t.co/yIRubED6VX

Links:

https://bit.ly/3iwXi1l

Dr. John Cush RheumNow ( View Tweet)

Oct 06, 2020

https://t.co/0bh6Mh2pKP

Adam Cifu adamcifu ( View Tweet)

Oct 05, 2020

"Prednisone >30 mg/day for > 4 weeks, patients should be on PJP prophylaxis." Image shows when to start/stop PJP prophylaxis Dr. Kevin Winthrop on Risks/Prevention of OI @UTSWRheum Grand Rounds @rheumnow https://t.co/nXuWYRxbgy

k dao KDAO2011 ( View Tweet)

Oct 05, 2020

Utilization study of 1031 tofacitinib vs 17,803 biologic DMARD Rx-patients shows 14% higher discontinuations w/ TOFA (HR 1.14), but pts who switched to tofacitinib from a bDMARD had longer persistence than pts switched to another bDMARD (HR 0.90) https://t.co/5cqloTTbjb

Links:

https://bit.ly/3nkAANg

Dr. John Cush RheumNow ( View Tweet)

Oct 05, 2020

Hellenic reigstry of 385 RA pts on DMARDs finds that, compared to remission or LDAS - those in persistent moderated disease activity had 50-80% more serious adverse events. https://t.co/3JA3VaMxeO

Links:

https://bit.ly/3jAyXcc

Dr. John Cush RheumNow ( View Tweet)

Oct 05, 2020

Among 406 axial SpA patients in the DESIR Cohort smoking was associated with MRI‐SI joint after 5 years of axial SpA patients and only in blue‐collar job or low education levels; suggesting a possible role for mechanical stress axial SpA. https://t.co/fcDjesdF8K

Links:

https://bit.ly/33sPMjC

Dr. John Cush RheumNow ( View Tweet)

Oct 05, 2020

Danish comparison of 15K RA, 301K Diabetes adn 75K gen population; RA assoc w/ increased risk of CHF (HR 1.51), MI (HR 1.58), stroke (HR 1.22) vs gen. population; but RA had 20-40% lower CHF/MI/CVA than diabetes pts (who had highest 10 yr mortality). https://t.co/R20EUPAlML

Links:

https://bit.ly/33gT5dP

Dr. John Cush RheumNow ( View Tweet)

Oct 02, 2020

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IL-1 Inhibition Alters Arthroplasty Rates

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Fractures from Delays in Denosumab Reinfusions

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Oral Dysbiosis May Antedate Rheumatoid Arthritis

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Systemic Steroids Reduce Mortality in COVID-19

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2020 Nobel Prize in Medicine Goes to the Discovery of Hepatitis C

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IL-1 Inhibition Alters Arthroplasty Rates Save

Fractures from Delays in Denosumab Reinfusions Save

Oral Dysbiosis May Antedate Rheumatoid Arthritis Save

Systemic Steroids Reduce Mortality in COVID-19 Save

2020 Nobel Prize in Medicine Goes to the Discovery of Hepatitis C Save

IL-1 Inhibition Alters Arthroplasty Rates

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Fractures from Delays in Denosumab Reinfusions

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Oral Dysbiosis May Antedate Rheumatoid Arthritis

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Systemic Steroids Reduce Mortality in COVID-19

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2020 Nobel Prize in Medicine Goes to the Discovery of Hepatitis C

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