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I mean, the EULAR recommendations for management of early arthritis are tough:
"1. Patients presenting arthritis... should be referred to, and seen by, a rheumatologist, within 6 weeks after the onset of symptoms"
Does it matter though?
https://t.co/wJkVHQZqjs
David Liew drdavidliew ( View Tweet)
Outcome measures => Validity and reliability from @sofiaramiro82 #EULAR2020 @RheumNow https://t.co/M3XIDsTK39
Dr Philip Robinson philipcrobinson ( View Tweet)
MAINRITSAN3 RCT, RTX v PLBO in AAV
28mo relapse free survival ⬇️ RTX (96% vs 74%, NNT~4), majr (100% vs 87%, NNT~8)
1. Selected grp (all pts from MAINRITSAN2)
2. All pts had GC q3mos - IRL benefit could be bigger?
Strong data for RTX >2yrs in AAV
PDF: https://t.co/Mbrq7bFHk0 https://t.co/auKJ3QPKr0
Mike Putman EBRheum ( View Tweet)
Yet another NEGATIVE Trial in Hand OA. Add Hand OA to the list that Includes Scleroderma, Sjogrens and CRPS as untreatable diseases with large unmet needs! https://t.co/cMMqmeo19N
Dr. John Cush RheumNow ( View Tweet)
Anti-CD74 IgA antibodies are most sensitive and specific to identify young male axSpA patients, data from @XBaraliakos and others: Abstract FRI0312 #EULAR2020 @RheumNow https://t.co/yrevk8Wsiw https://t.co/kzcje2rRNa
Links:
Dr Philip Robinson philipcrobinson ( View Tweet)
ASAS modification of the Berlin algorithm and the duet algorithm for diagnosing axSpA : results from the screening in axSpA for psoriasis, iritis, and colitis cohort: Abstract FRI0298 #EULAR2020 @RheumNow https://t.co/BkG7c2riRb https://t.co/f63MsxWmd3
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Dr Philip Robinson philipcrobinson ( View Tweet)
Drug retention rates & treatment outcomes in 1,860 axSpA patients Rx with secukinumab in routine clinical practice in 13 European countries in the EuroSpA research collaboration network -> registry data drug retention rates THU0398 @RheumNow #EULAR2020 https://t.co/x3Y4tMetij https://t.co/DkUyIfyWwS
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Dr Philip Robinson philipcrobinson ( View Tweet)
The Relative Diagnostic Utility of inflamm back pain criteria in inception cohort with PsO, Iritis, & Colitis Presenting With Undiagnosed Back Pain: All IBP criteria have poor diagnostic utility for dx of axSpA, esp in PsO Abs SAT0378 #EULAR2020 @RheumNow https://t.co/Y7sbtJtm3U https://t.co/P9q7uJozZ9
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Dr Philip Robinson philipcrobinson ( View Tweet)
Filgotinib was associated with significant reduction in SIJ erosion scores in axSpA: imaging data from the double-blind, randomized Tortuga trial #EULAR2020 @rheumnow THU0377 https://t.co/1b18Uyvo5j https://t.co/zBXCwGc0Q7
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Dr Philip Robinson philipcrobinson ( View Tweet)
Integrated safety analysis of filgotinib treatment for RA from 7 clinical trials: 4,057 patients, VTE risk looks very reassuring #EULAR2020 @RheumNow https://t.co/Ld2tpu7UT5 https://t.co/sZqadeUTh8
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Dr Philip Robinson philipcrobinson ( View Tweet)
The first randomized clinical trial of convalescent plasma in #COVID19, reported by Li et al in JAMA suggests that high titer antibody against #SARSCoV2 may have antiviral efficacy https://t.co/6YIib2GXGX
JAMA JAMA_current ( View Tweet)
Great talk on inflammasomes at #EULAR2020 by @dave_boucher: 4th June, 1:15pm, Ansell: Inflammasome activation in rheumatic diseases: mechanisms and perspectives for therapy @RheumNow https://t.co/HTWVxt4FMz
Dr Philip Robinson philipcrobinson ( View Tweet)
Replacing radiographic sacroiliitis with MRI structural damage doesn't change the classifciation of axSpA signifciantly @RheumNow #EULAR2020 Abstract SAT0384 https://t.co/MTTf4fHjYT
Dr Philip Robinson philipcrobinson ( View Tweet)
Preliminary definition of a +MRI for struc lesions in the SIJs in axSpA: Erosion in ≥2 consec slices or in ≥3 SIJ quad and fat lesion w depth >1cm in ≥1 SIJ quad are high priority for def an MRI struc lesion of axSpA. Abs OP0079 #EULAR2020 @RheumNow https://t.co/9RlSOUviJQ https://t.co/l4XiQDj8e4
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Dr Philip Robinson philipcrobinson ( View Tweet)
Secukinumab in nr-axSpA, in a mostly biologic naive cohort was effective: ASAS40 response of ~42%, data from the Phase III prevent trial Abstract OP0106 #EULAR2020 @rheumnow https://t.co/KATpGJs2y9 https://t.co/zeBFS2pMl0
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Dr Philip Robinson philipcrobinson ( View Tweet)
1/2 We all have hopes and dreams, and we all need to support ourselves, our families and our communities reach their full potential. Racism, bigotry and hate have no place in a civilised respectful world.
Dr Philip Robinson philipcrobinson ( View Tweet)
2/2 We all have a part to play by stepping up and making a difference, sometimes in a small way, sometimes in a bigger, but we are all presented with opportunities to do the right thing. Making that choice and taking that action is showing you care. https://t.co/Zk3VcnJjBw
Dr Philip Robinson philipcrobinson ( View Tweet)
I'm really humbled by the amazing ongoing effort to collect cases for @rheum_covid. So many ppl are working tirelessly to help including the steering committee, patients & the pt board, contrib. rheums & the CASC. Please continue to contribute cases. Thank you 🙏 https://t.co/cK4FZXquMp
Dr Philip Robinson philipcrobinson ( View Tweet)
And another one! No association of MTX with worsening of ILD in this study by Men-Vazquez et al. #EULAR2020 https://t.co/X7C6KyC29L
Richard Conway RichardPAConway ( View Tweet)
#Eular2020 #op0224 filgotinib successfully reduces levels of circulating biomarkers in PsA suggestive of clinical efficacy: CRP&SAA >50%, IL6, CXCL10&IL23 >25%. Also decreased ICAM1,VCAM1, MMP1&SC1M @RheumNow
Olga Petryna DrPetryna ( View Tweet)