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Adverse Effects of Low-Dose Methotrexate from the CIRT Trial

d Jack Cush, MD

Low-dose methotrexate (LD-MTX) was studied in high risk cardiac patients in the cardiac intervention trial (CIRT), but was prematurely ended for not showing a change in cardiovascular event rates. Nonetheless this trial studied the safety and adverse event rates of LD-MTX and those results are reported in the current issue of Annals of Internal Medicine.

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BSR Guidelines for Giant Cell Arteritis

d Jack Cush, MD

NICE has commissioned an update to the 2010 British Society for Rheumatology guideline for the management of giant cell arteritis, and proposed a total of 19 recommendations for the diagnosis and treatment of GCA.

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Primary Care Visits Decline 2008-2016

d Jack Cush, MD

A national claims-based analysis has shown a consistent decline, by commercially insured adults (18-64 yrs), in primary care physician visits from 2008 to 2016; with nearly one half having no PCP visits in a given year by 2016. 

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Pregnancy study from Alberta compared population with (308,989), RA (631), SpA (2461) - showed RA more likely to be complicated by preterm delivery (13.5%), C-section (34%), HTN in preg (10.5%), and SGA (15.6%). No incr found in SpA women https://t.co/c3WkCVOg4e

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Dr. John Cush RheumNow ( View Tweet)

Slovenian National TB Registry (a non-endemic area w/ TB rate 6/100k similar to US). 2429 TNFi exposed (RA, AS, PsA)-6% required TB chemoprophylaxis; 6 RA and 2 PsA developed TB; 2 pts died. The TB incidence rate for TNF Rx pop was 45-51/100kPYs https://t.co/tam5I17QO1

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Dr. John Cush RheumNow ( View Tweet)

FDA has approved OTC voltaren (diclofenac) gel, now called Voltaren Arthritis Pain for arthritis & OA pain; it is not for immediate relief and may take up to 7 days to work. Pts should seek medical attention If they need to use this product for >21 days. https://t.co/qTcbPZDcqa

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Dr. John Cush RheumNow ( View Tweet)

"In the course of my life, I have often had to eat my words, and I must confess that I have always found it a wholesome diet." -Winston Churchill

Dr. John Cush RheumNow ( View Tweet)

THe QD Clinic compilation Podcast 70-72 https://t.co/F11j7F4tZZ

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Dr. John Cush RheumNow ( View Tweet)

RheumNow Podcast is up! Cool stuff and quips from the RWCS meeting! Watch the video here https://t.co/F8tS8nkLLB or listen to it on iTunes or here https://t.co/F11j7F4tZZ

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Dr. John Cush RheumNow ( View Tweet)

COPA - multiple auto antibodies, ILD in kids. Genetic testing needed to Dx. https://t.co/RcLUhi6piJ
Dr. John Cush RheumNow ( View Tweet)
Engagement in sports increased odds of OA. Dr Wm Bugbee at #RWCS2020 @RWCSmtg https://t.co/HGh4jkF3HF
Dr. John Cush RheumNow ( View Tweet)
Important acronyms in both Ortho and Rheum. Dr Wm Bugbee at #RWCS2020 @RWCSmtg https://t.co/guqjPwkoFT
Dr. John Cush RheumNow ( View Tweet)
Primary immunodeficiency warning signs in adults; 25% of OID will develop an autoimmune disease. Dr Anna Postolova at #RWCS2020 @RWCSmtg https://t.co/c84Sybg95W
Dr. John Cush RheumNow ( View Tweet)
Dr. Anna Postolova @StanfordHealth outlines key warning signs for primary #immunodeficiency among children and adults: “25% of patients with PID will develop an #autoimmune disease” #RWCS2020 https://t.co/VWYYO6gMpR https://t.co/jjsiZnNuO6

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Healio Rheumatology HealioRheum ( View Tweet)
Primary immune deficiency syndrome is more common than you think in autoimmune diseases. Conversely 25% of in nine deficiency pts have an autoimmune disease. Think repeated infections and allergies in your pts @RWCSmtg @RheumNow #RWCS2020 https://t.co/iXOf6G9wCD
Janet Pope Janetbirdope ( View Tweet)
Do you work up pt with frequent infections who has RA SLE or vasculitis? Common variable immune deficiency is .....COMMON @RWCSmtg @RheumNow #RWCS2020 https://t.co/CNHsayBst5
Janet Pope Janetbirdope ( View Tweet)
If asthma and allergies ask about atopic dermatitis. Most are kid onset but continue or recur in adulthood. Tip atopic dermatitis can increase with TNFis. New Rx and JAKis are entering this disease too. George Martin #RWCS2020 @RheumNow https://t.co/HqU05h5Vkb
Janet Pope Janetbirdope ( View Tweet)
Dr. Postolova recommends checking immunoglobulins and flow cytometry on every patient prior to starting RTX. #RWCS2020 @RheumNow @RWCSmtg

Dr. Rachel Tate uptoTate ( View Tweet)

Sarcoid and CVID can look alike as both get Granulomatous lessons. Dr Anna Postolova at #RWCS2020 @RWCSmtg https://t.co/TREQwYYrgc
Dr. John Cush RheumNow ( View Tweet)
A high percentage of complement deficiencies will develop lupus. Dr Anna Postolova at #RWCS2020 @RWCSmtg https://t.co/IItg1Ezd3F
Dr. John Cush RheumNow ( View Tweet)

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