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Bariatric Surgery Improves Rheumatoid Activity

d Jack Cush, MD

Obesity is a risk factor for the onset of rheumatoid arthritis (RA) and may also an impediment to optimal DMARD and biologic responses.  A new study has shown that after 1 year, obese RA patients undergoing bariatric surgery with weight loss had significantly lower disease activity.

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ACR Releases Reproductive Health Guidelines for Rheumatic Diseases

d Jack Cush, MD

Today, the American College of Rheumatology (ACR) published the 2020 Guideline for the Management of Reproductive Health in Rheumatic and Musculoskeletal Diseases.

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Methotrexate and the Risk of Lung Disease

d Kathryn Dao, MD

Rheumatology has a comprehensive overview of methotrexate (MTX) and the risk of lung injury, MTX-related pneumonitis and interstitial lung disease (RA-ILD) with rheumatoid arthritis (RA).  Past reports suggest the frequence of MTX-pneumonitis to be between 0.3 and 11.6%; r

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Hyperuricemia Predisposes to Coronary Artery Disease in Men

d Jack Cush, MD

There are numerous associations between hyperuricemia and cardiovascular disease (CVD). An analysis of the Swedish SCAPIS Pilot study shows that higher levels of serum urate (SU) are associated with an increase in coronary artery calcification score in men but not in women. SU is not associated with common carotid intima-media thickness and carotid plaque scores in either men or women.

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Pregnancy Outcomes Improve in Lupus

d RheumNow

Pregnancy for patients with lupus has long been considered high risk and associated with both medical and obstetric complications, but outcomes have improved over the last 2 decades and continue to improve.

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No Cancer Increase in Psoriatic Arthritis or with Biologics in Psoriasis

d Jack Cush, MD

JAMA Dermatology reports that psoriasis is associated with a slightly increased risk of cancer, particularly keratinocyte cancer and lymphomas.

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RheumNow Podcast- Half-Empty Flu (2.21.20)

d Jack Cush, MD

Dr Jack Cush reviews the news and journal articles from the past week on RheumNow.com

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Tofacitinib Effective in Refractory Still's Disease

d Jack Cush, MD

Fourteen cases reported from mainland China suggest that tofacitinib (TOFA) may be effective in patients with refractory adult-onset Still’s disease (AOSD), further adding to a growing list of potential use of JAK inhibition in managing inflammatory, and now autoinflammatory, disease.

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Seronegativity on the Rise in RA

d RheumNow

Although the overall incidence rates of rheumatoid arthritis (RA) have remained stable over recent decades, there has been a significant increase in seronegative cases, a retrospective study showed.

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"Difficulties mastered are opportunities won." - WInston Churchill

Dr. John Cush RheumNow ( View Tweet)

Brazil Biologics registry studied 1121 RA & 577 SpA pts and found serious infectious adverse events were more common with first TNFi (adjusted IR ratio, 2.96; p < 0.001) & still higher with 2nd TNFi (vs 1st TNFI) (adjusted IR ratio, 1.55) https://t.co/FpliYorsyG

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Metanalysis of homocysteine (HCY) levels in SLE; 36 articles compared 2919 SLE to 3120 controls. HCY levels were significantly higher in SLE vs healthy controls (P < 0.001), esp w/ age, Dz activity, Dz duration and BMI >23. HCY is important in SLE https://t.co/NVQ4KRJMR4

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Dr. John Cush RheumNow ( View Tweet)

FDA has approved IV meloxicam injection (called Anjeso, from Baudax Bio) for the treatment of moderate to severe pain in adults. Based on two phase 3 efficacy trials and one phase 3 safety study. https://t.co/5coeDacq7M

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Dr. John Cush RheumNow ( View Tweet)

"Play the game for more than you can afford to lose... only then will you learn the game." -Winston Churchill

Dr. John Cush RheumNow ( View Tweet)

Cross sectional study of 139 RA patients shows that severity of periodontal disease on dental exams was linearly associated with both the presence and levels of anti-CCP antibodies. https://t.co/T4Ic5ViZgl

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Dr. John Cush RheumNow ( View Tweet)

RheumNOW Podcast is up! Info on Flu vax, Tofa in AOSD, MTX safety, TNFi-TB risk, JAKs and osteoblasts & more. You can watch it here>> https://t.co/aa6R3vQ108 or listen to the podcast on iTunes or SoundCloud>>https://t.co/c7PFO3KOOa

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"Never in the field of human conflict was so much owed by so many to so few." - Winston Churchill

Dr. John Cush RheumNow ( View Tweet)

Dr A Reimold @UTSWIMchief @RheumNow on SpA Risks for SpAprogression https://t.co/5ETqFSa54s
k dao KDAO2011 ( View Tweet)
QD Clinic - Dosing RTX and Remicade - listen to the podcast on iTunes or here https://t.co/MXNZ9uqBWE

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Dr. John Cush RheumNow ( View Tweet)

"Courage is what it takes to stand up and speak; courage is also what it takes to sit down and listen." - Winston Churchill

Dr. John Cush RheumNow ( View Tweet)

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