All News

CBD.jpg

FDA Warns 15 CBD Manufacturers

d Jack Cush, MD

Today, the U.S.

Read Article

RheumNow Podcast - Monitoring Methotrexate Safety (12-6-19)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com.

Read Article
patient.safety.jpg

Biologic Safety Guidelines from the British Society for Rheumatology

d Jack Cush, MD

In the United Kingdom, NICE has looked to the British Society of Rheumatology (BSR) to develop evidence based guidance on the safe use of biologic DMARDs in patients with inflammatory arthritis.

Read Article
heels%20hurtin.jpg

Secukinumab Improves Enthesitis

d Jack Cush, MD

Secukinumabs (SEC) effect on enthesitis in psoriatic arthritis (PsA) was studied in the FUTURE 2 and 3 studies and SEC was shown significantly reduced enthesitis by more than 65% within 14 week. 

Read Article
stop.smoking.jpg

Smoking Cessation Lowers RA Disease Activity and CV Risks

d Jack Cush, MD

A multinational cross-sectional cohort study suggests that smoking cessation in rheumatoid arthritis (RA) patients is associated with lower disease activity measures, improved lipid profiles and lower rates of cardiovascular (CV) events.

Read Article
pregnant.belly-1-1314508.jpg

Spondyloarthritis Affects Pregnancy Outcomes

d Jack Cush, MD

A Danish registy has shown that the the prevalence of Spondyloarthritis (SpA) diagnosed prior to delivery has increased 5 fold in the last two decades and that SpA is associated with an increased risk of adverse pregnancy outcomes (APO).

Read Article
The RheumNow Podcast is up! Monitoring Methotrexate Safety, Palmoplantar pustulosis, diet in SLE, enthesitis Rx, & benefits of smoking cessation..... Listen here>> https://t.co/zoFp2vc7EB

Links:

Dr. John Cush RheumNow ( View Tweet)

Newly Dx #SLE patients have a 62% higher risk of hip fracture. Canadian matched cohort study of 5,047 incident SLE vs and 25,235 non-SLE showed more hip fractures in SLE (HR=1.62 [95% CI; 1.06-2.48]). Implications for OP prevention in SLE patients? https://t.co/oDbYZPwMXD

Links:

Dr. John Cush RheumNow ( View Tweet)

ACR MTX monitoring guidelines from 1994 (Alarcon et al) -pts should be screened for HBV, HCV, Alb. At AST, ALT should be checked at intervals of every 4-8 weeks. MTX should be stopped/adjusted or liver Bx if AST abnl in 5 of 9 (or 6/12) in 12 mos. https://t.co/8lcPz7sH3F

Links:

Dr. John Cush RheumNow ( View Tweet)

Data from 5 RCTs of 733 pts with systemic necrotizing vasculitis examined risks for serious infection (SIE), finds that 20.2% had SIEs and 2/3 these occured within the first 2 yrs. Age, Lung involvement & 5 Factor Score were independent predictors of SIE https://t.co/imHVsZgVfG

Links:

Dr. John Cush RheumNow ( View Tweet)

Propensity Score–Matched Cohort claims study compared 11,248 matched pairs RA pts starting either abatacept or TNF inhibitor. ABA had a signficiantly lower risk of hospitalized infx compared to infliximab (HR 0.63), but equal SIE risk vs ETN or ADA. https://t.co/brid5dAdIh

Links:

Dr. John Cush RheumNow ( View Tweet)

Palmoplantar pustulosis has very low prevalence rates (<0.1%), qualifying as an orphan disease, Registry data from US, Denmark, Germany identified 1,435, 751 and German PPP patients, respectively; 14-61% also have Psoriasis, with higher risk of PsA https://t.co/S6r4GtG3bF

Links:

Dr. John Cush RheumNow ( View Tweet)

Ultrasound study of 980 #gout pts finds Bone erosions were seen in 44%, with 78.4% of these found in the first metatarsophalangeal (MTP) joint. Independent predictors include age, duration of gout, tophi, US synovitis and and joint effusion. https://t.co/LxjgfM29Xd

Links:

Dr. John Cush RheumNow ( View Tweet)

Of 1757 systemic sclerosis patients in the EUSTAR study, 25% had diffuse SSc and 9% had current or previous digital gangrene, 16% had digital ulcers (DUs), not CV risk factors. https://t.co/31ypT1V1zO

Links:

Dr. John Cush RheumNow ( View Tweet)

Meta-analysis of 30 studies shows that ACPA-positive RA patients are marginally more likely to achieve EULAR and ACR20 responses with abatacept (RR 1.18; 95% CI 1.03, 1.35), but not with TNFα-i (RR 0.97; 0.86, 1.10) (compared to ACPA-negative) https://t.co/V5CviFVSGt

Links:

Dr. John Cush RheumNow ( View Tweet)

ACR/ARP 2019 attendees get “sneak preview” of updated gout clinical practice guideline → https://t.co/VRyfj75nVu #ACR19

Links:

American College of Rheumatology ACRheum ( View Tweet)

Metanalysis shows that although MTX may blunt some vaccine responses (eg Pneumococcal), the use of MTX, TNF inhibitors and other biologics should not deter vaccination as most vaccine responses are preserved despite therapy. https://t.co/KINrQMIQkt

Links:

Dr. John Cush RheumNow ( View Tweet)

Study of two dietary patterns and the risk of SLE from the Nurses' Health Study (NHS, 1984–2014) and Nurses' Health Study II (NHSII, 1991–2015) shows no association between incident lupus and (healthier) prudent or (less healthy) Western diet. https://t.co/tvX2HqzWxF

Links:

Dr. John Cush RheumNow ( View Tweet)

Spinal/SI MRI in the gen. population finds a high frequency of inflammatory and fatty MRI lesions suggestive of axSpA. MRI done in 793 volunteers < 45 yrs (49% males, 8.4% B27+). SI tJ Bone marrow edema in 17%, Vertebra BME 27% & fatty lesions in 81% https://t.co/XOzyWCyLyC

Links:

Dr. John Cush RheumNow ( View Tweet)

Norways HUNT study shows NO fracture risk with PPI use in 15,017 women and 13,241 men aged 50–85 years. PPIs were not associated with an increased risk of fracture age-adjusted HR 0.82 (0.67–1.01) for women; 1.05 (0.72–1.52) for men. https://t.co/XIAdvxGTrz

Links:

Dr. John Cush RheumNow ( View Tweet)

×