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Weak Data (1.24.2025)
Dr. Jack Cush reviews the news and journal reports from RheumNow.com, and features Dr. Charity Dean, the Keynote speaker at RheumNow Live 2025, and why she is an inspiration.
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Honoring Dr. Dafna Gladman
In December 2024, the Governor General appointed Dr. Dafna Gladman an officer to the Order of Canada, which includes some of Canada's most notable Clinicians and Scientists. Created in 1967, the Order of Canada is one of Canada's highest civilian honours. It recognizes individuals whose achievements and service have had an impact on communities across Canada and beyond.
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Getting to Remission - Without Biologics
Analysis of data from two early rheumatoid arthritis (ERA) cohorts shows remission in RA is primarily seen in those who do not require biologic DMARDs (bDMARDs), while those needing bDMARDs are less apt to achieve remission.
Head-to-Head Clinical Trials
https://t.co/tt8uLuLiV2 https://t.co/BvWxCGGN5V
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Lung Involvement in Still's Disease
A multicentre registry observational study assessed lung involvement in a cohort of Still’s disease patients, affirming pleuritis as most common and that parenchymal lung inflammatory disease is very uncommon in both children and adults.… https://t.co/rGYEgCeUDA https://t.co/fdUGvfU8HH
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“Nothing in all the world is more dangerous than sincere ignorance and conscientious stupidity.”
- Martin Luther King
(Isnt that when someone says “I don’t know and I don’t care”) https://t.co/ZDwyyhX9XT
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post hoc analysis of 4 registration trials of pegloticase, show rates of MACE and Thromboembolic Events were Infrequent (<1.5%; 35.4 events/1000 PY), similar to general gout population (31.7 events/1000 person-years) https://t.co/v6ZqtL4yB2 https://t.co/NA0j20Oew2
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Worldwide, it is estimated that arthralgia treatments cost USD 4.7 Billion in 2024 and is estimated to reach USD 9.0 Billion by 2035. https://t.co/DYnbhpLAhr https://t.co/sKR8sssKNx
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QD Clinic - ANA Negative Lupus
Pregnant ANA negative SLE (?) patients with Sjogrens and FM - what to do?
Features Dr. Jack Cush.
QD Clinics - lessons from the clinic, sponsored by RNL2025 in Dallas, TX; Feb 8 & 9, 2025
Register at https://t.co/2dcFVgu8z6… https://t.co/RyCdiadn4H https://t.co/EvWcQ6KIxQ
Links:
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Do Rheumatologists Follow 2020 ACR Guidelines on Gout?
Schlessinger and colleagues report that US Rheumatologists generally adhere to and agree with the 2020 American College of Rheumatology (ACR) Guideline for the Management of Gout, although knowledge gaps and practice… https://t.co/UA7LX016Fl https://t.co/xKKX26vABr
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Functional Precision Medicine in Rheumatoid Arthritis
Novels research from the Medical University of Vienna demonstrates the plausible utility of functional precision medicine (FPM) using immunophenotyping of blood cells (PBMCs) with rheumatoid arthritis (RA), to help guide… https://t.co/1T92Ax9pW7 https://t.co/FjIqTIxjUu
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French cross-sectional study of pts on stable sc MTX x several yrs. Examined MTX polyglutamates (MTX-PGs) & disease activity in 34 RA pts (25 remission). + correlation between RA remission & high MTX-PG3 levels in pts w/ BMI <25. BMI may limit utility of PG3 levels… https://t.co/scFzVy7hhA https://t.co/sUQUHFbhaG
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“If I cannot do great things, I can do small things in a great way.”
- Martin Luther King https://t.co/2ixHPDdN1q
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Palmar fasciitis & polyarthritis syndrome (PFPAS). JAMA case 50yoM w/ progressive hand swelling, stiffness, thickening, erythema, hepato-splenomegaly. Skin Bx dermal fibrous tissue. WBC 152k, LDH 889, lead to CML dx made by BM Fx (myeloid-erythroid ratio 21 w/ myeloblasts). +… https://t.co/7gj3mvOSqs https://t.co/56tLd1jsNf
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Rheum to Travel
Meeting new people is a key benefit of attending conferences. At one symposium, I met a unique rheumatologist, Holly Bastian, MD, who practices without being tied to one place. As a nomadic rheumatologist, she spreads her skills and knowledge to areas needing… https://t.co/maONMwlL72 https://t.co/CHsHb6FnMG
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Cardiovascular Risk in Cutaneous Lupus Erythematosus
A retrospective study of cutaneous lupus erythematosus (CLE) patients finds an increased risk of atherosclerotic cardiovascular disease (ASCVD) on par with systemic lupus patients.
https://t.co/3gEkFBK8wc https://t.co/kagpp7w7nE
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Korean Biologics (KOBIO) registry showed SpA pts have higher risk of infection. 2,129 AS pts (7108 PY FU) most common was respiratory infx (26/1000 PY), followed by herpes zoster (6/1000 PY) Risk includes age, ischemic CV Dz, diabetes, CKD, peripheral arthritis.… https://t.co/0j1fH7OymW https://t.co/gqa1csylsn
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RA higher risk of Celiac Dz -- Rheumatic Dz administrative data review (2004–2013)compared 70,061 #RA w/ 276,895 controls, median F/U 9 yrs. (IQR 9–9). Celiac Prevalence higher in RA (171/70,061 = 0.24% vs 398/276895 = 0.14%; p < 0.001), more so in females w/ RA… https://t.co/SayZYvkZpV https://t.co/fcuyJ5sFk0
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Korean population-based study shows that from 2010 to 2023 prevalence of ank Spondylitis (AS) increased 27 per 100,000 (2010) to 82 per 100,000 (2023). Also increasing were # of pts >50 yrs (20-33%), #females (18-24%), Comorbidities, TNFi use (30-43%), while csDMARDs declined.… https://t.co/9NjU1IugaF https://t.co/kTCtIj2BjD
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A substantial # of pts with inflammatory arthritis (IA) are not receiving adequate treatment for depression and anxiety(same as those IA-free controls). Canadian study of 6,951 w/ IA & depression, on 50% recv treatment & 20% psych. Rx for depression. Similar for 3,701 w/ IA &… https://t.co/CfpwEtLH3c
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