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Utility of Drug Levels and Anti-Drug Antibodies When Starting TNF inhibitors
A prospective cohort of 331 patients tested for anti-adalimumab (n=160) and anti-etanercept (n-171) antibodies after initiation of their TNF inhibitor therapy.
Read ArticleAdherence to ETN/MTX is Greater Than Triple DMARD Therapy
Rheumatoid management hinges on choosing your best therapies first.
Read ArticleThe History of Citrullination
1998 marked the introduction of citrulline as a unique target in the pathogenesis of rheumatoid arthritis. The hallmark article by Schellekens et al in the Journal of Clinical Investigation has since been cited over 500 times. Dr.
Read ArticleBrain Natriuretic Peptide Measurement in Rheumatoid Arthritis
Cardiovascular (CV) risk and adverse cardiac outcomes are common in rheumatoid arthritis (RA). It has been presumed that chronic systemic inflammation has a deleterious effect on the myocardium and vasculature, thereby leading to higher rates of MI, CHF and CV death.
Read ArticleThiazide Diuretics May Reduce Osteoporotic Fracture Risk
A large Swedish cohort study of hypertensive men and women presented at the 25th Scientific Meeting of the European Society of Hypertension, identitied a protective effect on osteoporotic fractures among current users of thiazide diuretic drugs independent of blood pressure level. This retr
Read ArticleFrequency of Infliximab Infusion Reactions
A Canadian registry shows that in community-based infusion clinics, infusion reactions to IFX are uncommon and mild to moderate in nature.
Read ArticleCosmic Etiology to RA and Polymyalgia Rheumatica
Researchers at Johns Hopkins, Mayo Clinic and the NIH have determined that solar cycles and geomagnetic effects may account for the incidence of RA and PMR.
Read ArticleExpanding Global Biosimilar Market
Between 2010 and 2013, $95 billion in branded pharmaceutical patents will have expired, leading to significantly higher sales opportunities for those manufacturing generics and biosimilars.
Read ArticleThe EULAR 2015 Report- Friday
These abstracts and presentations were presented 12 June at the EULAR 2015 annual meeting.
Read ArticleThe EULAR 2015 Report - Wednesday
EULAR 2015 started the afternoon of Wednesday June 10th.
Read ArticleRheumatic Manifestations of Chikungunya Virus
Chikungunya is a new viral cause of fever and arthritis, especially in endemic areas like the caribbean. The chikungunya epidemic has grown significantly in the Western hemisphere with a total of 1,247,000 cases and 183 fatalities since
Read ArticleHigh Flare Rates with Drug Withdrawal in JIA
While many adult rheumatologists are able to lessen or withdraw DMARD and biologic therapy in adults, little is known about the success of this practice in pediatric rheumatology clinics.
Read ArticleKnee Implant Forecast from 2012 - 2018
The global knee implants market was USD 8.4 billion in 2011, and it's forecasted to reach USD 15 billion in 2018, with compound annual growth rate of 8.64% during 2011 to 2018. The U.S.
Read ArticleComorbidities Increasing in Arthritis Patients
A CDC report shows comorbid conditions exist in 73.1% of all arthritis patients. Based on NHIS survey data, the number of patients with 2 or more comorbid conditions has increased from 21.8% in 2001 to 25.5% in 2012. Most affected were older adults (≥65 years), women, wh
Read ArticleMedicare D and Costly Biologics
25% of Medicare beneficiaries with rheumatoid arthritis use high-cost biologics. Yazdany and coworkers have analyzed a national cohort of beneficiaries and compared Medicare part D plans.
Read ArticlePrevalence of doctor-diagnosed arthritis and activity limitations
52.5 million US adults (22.7%) have arthritis with half of these claiming activity limitation because of arthritis and pain. Many arthritis patients have comorbid conditions including heart disease (49%), diabetes (47%) and obesity (31%).
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RA Sarilumab Trials Meet Primary Endpoints
Three phase III studies of sarilumab (SARIL-RA-TARGET, -EASY and -ASCERTAIN), a fully-human IL6 receptor antibody, have been reported and met primary end points in these pivotal clinical trials.
Read ArticleA Microneedle Pill as an Alternative to Injectable Drug
Carl Schoellhammerhas just won the Lemelson-MIT National Collegiate Student Prize for his invention - the microneedle pill.
Read ArticleThe Danger Model as an Alternative Cause of Autoimmunity
The danger model was proposed by Matzinger as an alternative (or complement) to the traditional self-non-self (SNS) model of autoimmunity.
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