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The concept of a “Still’s disease continuum” that encompasses both sJIA and AOSD is based on the many common clinical, genetic and laboratory features shared by both sJIA and AOSD.
162 #AOSD or #sJIA criteria+ pts underwent genetic testing - 31% (51/162) had a genetic variant for periodic fever Dx. 4

Dr. John Cush RheumNow

4 years 2 months ago
162 #AOSD or #sJIA criteria+ pts underwent genetic testing - 31% (51/162) had a genetic variant for periodic fever Dx. 4 SJIA pts were confirmed to have FMF or TRAPS. Genetic testing may be smart, esp w/ atypical presentations https://t.co/hwZFgOL4j4 https://t.co/6y8r1Dyv1A
Abatacept Most Effective Early and in Seropositive RA

A 2 year study evaluated the efficacy and safey (drug retention)

Dr. John Cush RheumNow

4 years 2 months ago
Abatacept Most Effective Early and in Seropositive RA A 2 year study evaluated the efficacy and safey (drug retention) of subcutaneous ABA in active RA and showed superior responses when ABA was given to biologic-naive and seropositive RA patients. https://t.co/WdZ3YCeGXg https://t.co/4ZjFFrVmSJ
11.5% of Crohns pts have TNFi use contraindications (either MS, CHF, neoplasia, infx risk, TNFi AE, comorbidities, SLE.

Dr. John Cush RheumNow

4 years 2 months ago
11.5% of Crohns pts have TNFi use contraindications (either MS, CHF, neoplasia, infx risk, TNFi AE, comorbidities, SLE. Alternatively GI survey respondents use ustekinumab (76%), vedolizumab (249%), or tofacitinib (0.5%) https://t.co/NqGOislcIJ https://t.co/tqk3jF3Lxg
Cochrane metanalysis of sleep meds - 170 trials (36 interventions, 47950 pts). Doxepin, seltorexant, zaleplon well toler

Dr. John Cush RheumNow

4 years 2 months ago
Cochrane metanalysis of sleep meds - 170 trials (36 interventions, 47950 pts). Doxepin, seltorexant, zaleplon well tolerated, but efficacy data is scarce. Benzodiazepines, eszopiclone, zolpidem, were more efficacious, but zolpidem more dropouts due to AEs https://t.co/8mPYmfTAaR https://t.co/DqUFcgq9AR
Placebo responses are to be expected in rheumatoid arthritis (RA) clinical trials, but are such placebo responses affected by continuing background DMARDs like methotrexate (MTX) even though there was an inadequate response (IR) to MTX? 
For about one in six people considered healthy with no reports of back pain, lesions were visible on MRI in the lower spinal column and sacroiliac joint, researchers said -- a sign that rheumatologists should be cautious about diagnosing spondyloarthritis (SpA) on the basis of imaging.
Leflunomide versus azathioprine in lupus nephritis? Study of 215 bx proven LN given either LEF or AZA - Renal flares wer

Dr. John Cush RheumNow

4 years 2 months ago
Leflunomide versus azathioprine in lupus nephritis? Study of 215 bx proven LN given either LEF or AZA - Renal flares were equal (15.7% v 17.8%), as was time to flare (16 mo vs AZA 14 mo); 24-hr proteinuria, creatinine, C3 and C4 improved similarly. https://t.co/FEKwwyoJhZ https://t.co/zUyHXGjpOD
Rheumatologist Survey:
What do you rely on MOST in diagnosing Still’s disease?
Sxs? Labs? Both? Criteria? Fever? Vote

Dr. John Cush RheumNow

4 years 2 months ago
Rheumatologist Survey: What do you rely on MOST in diagnosing Still’s disease? Sxs? Labs? Both? Criteria? Fever? Vote here: https://t.co/L1kyWXf68I
An open-label, 2 year study evaluated the efficacy and safey (drug retention) of subcutaneous (SC) abatacept (ABA) in active rheumatoid arthritis (RA) and showed superior responses when ABA was given to biologic-naive and seropositive RA patients. 
Watch: Remote Monitoring Technologies in the Management of RA

Dr. Antoni Chan interviews Dr. Johannes Knitza at EULAR 2

Dr. John Cush RheumNow

4 years 2 months ago
Watch: Remote Monitoring Technologies in the Management of RA Dr. Antoni Chan interviews Dr. Johannes Knitza at EULAR 2022 https://t.co/SU9SUScHiS https://t.co/YoxQPZH5eQ
Seminal Articles on Stills disease Tues Nite Rheum Journal Club tommorrow
Discussants: Drs. Bella Mehta, Michael Weisman

Dr. John Cush RheumNow

4 years 2 months ago
Seminal Articles on Stills disease Tues Nite Rheum Journal Club tommorrow Discussants: Drs. Bella Mehta, Michael Weisman & Jack Cush 7pm EDT (4pmPDT) - The 1st articles on AOSD from Bywaters & Bujak https://t.co/yRgHlmZHhi https://t.co/ooexkgM6ga Register: https://t.co/kstge3gAcl https://t.co/XjQJi4FRmt
Study of 50 #AOSD pts refractory to steroids (n=11), DMARDs (34) & biologics (n 30): given canakinumab 150–300 mg

Dr. John Cush RheumNow

4 years 2 months ago
Study of 50 #AOSD pts refractory to steroids (n=11), DMARDs (34) & biologics (n 30): given canakinumab 150–300 mg q 4wk (47) or q8wk(3). W/ 27 mos F/U: 78% complete resp w/in 3 mos (20% partial). Steroid sparing in 1/2, Low WBC 6%, 4%SIE https://t.co/QMCLictdrL https://t.co/5hkUOBFDG0
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