Natalie McCormick, PhD, of the Rheumatology and Allergy Clinical Epidemiology Research (RACER) Center within the Division of Rheumatology in the Mass General Brigham Department of Medicine, is the lead author of a paper published in Diabetes Care, “
Dr. John Cush RheumNow
5 months 3 weeks ago
DMARD Responses in Localized Scleroderma
JAMA Dermatology has published the results of a juvenile localized scleroderma (JLS) trial showing that mycophenolate mofetil (MMF) and methotrexate (MTX) are equally effective in treating JLS, noting low flare rates and possibly better https://t.co/NIR0ejs1RL
Dr. John Cush RheumNow
5 months 3 weeks ago
Potential New Rheumatology Drugs for 2026. These have had successful phase III RCTs and will need to be reviewed by regulators:
** deucravacitinib (Sotyktu) Tyk2 inhib for PsA
** Icotrokinra (Icotyde) oral IL-23i for psoriasis
** brepocitinib TYK2/JAK1 inhibitor for https://t.co/CQmfjIDMp3
Dr. John Cush RheumNow
5 months 3 weeks ago
NEJM: Aortitis Due to Large-Vessel Vasculitis
63yoM w/ Hx HTN c/o 3 mos of CP, palpitations, abdominal pain. ESR-104, CRP 85 mg/L. CT showed thickening of the thoracic & abdominal aorta. After 6wks Rx w/ AZA, HCQ, Pred, ESR/CRP still high and pt stared on SC TCZ w/ improvement. https://t.co/IWm3ZQLBUN
Dr. John Cush RheumNow
5 months 3 weeks ago
FDA has announced "Breakthrough Designation" for 3 drugs + 1 test being developed:
** Biogen: litifilimab (targets dendritic cells) for cutaneous lupus
** Novartis: Ianalumab (BAFF blockade) for Sjogrens
** J&J: Nipocaiimab (FcRn) for Sjogrens
** Encarta: pocket Lyme test https://t.co/zODOTWyqP8
Dr. John Cush RheumNow
5 months 3 weeks ago
Congratulations to Dr. Cheryl Barnabe for receiving the 2026 Distinguished Investigator Award from the Canadian Rheumatology Association, for her excellence in rheumatology research & clinical care. Dr. Barnabe is a professor at the University of Calgary https://t.co/xxNI8qR9sn https://t.co/zHkAOoyD7f
Dr. John Cush RheumNow
5 months 3 weeks ago
Air pollution ups ANA+: Ontariio Canadi study of 3548 serum samples (2010-13) corrlated particulate matter (PM2.5) w/ serologies. Highest vs lowest quartile PM2.5 showed higher risk of ANA ≥1:640 (OR 1.46) & ≥1:1280 (OR 1.54). Pollution has systemic immune effects! https://t.co/fJrhypNE2A
Dr. John Cush RheumNow
5 months 3 weeks ago
The EMA CHMP has started a review of oral complement C5 inhibitor avacopan (Tavneos) based on serious questions about amendments to the data from the pivotal ADVOCATE study. The drug was approved in 2021 for use in GPA & MPA. https://t.co/a5ggUqk1dG
Dr. John Cush RheumNow
5 months 3 weeks ago
TOPKAT Trial: Partial vs Total Knee Replacement
Patients with osteoarthritis (OA) primarily affecting only one knee joint compartment did just as well with partial knee replacement (PKR) as with total arthroplasty after 10 years in a randomized trial -- and maybe a little bit https://t.co/MNpVeHQbJ2
Dr. John Cush RheumNow
5 months 3 weeks ago
DMARD Responses in Localized Scleroderma
JAMA Dermatology has published the results of a juvenile localized scleroderma (JLS) trial showing that mycophenolate mofetil (MMF) and methotrexate (MTX) are equally effective in treating JLS, noting low flare rates and possibly better https://t.co/BbIS5rdRYU
Arthritis Society Canada (ASC) is Canada’s largest charitable funder of cutting-edge arthritis research, investing more than $240 million in research projects since its founding, and over $7 million invested in 2024-2025. Below are the investigators and projects that were funded in 2025.
A current large rheumatoid arthritis (RA) cohort study from Cairo assessed methotrexate (MTX) use and found over half were MTX intolerant and a third of patients were noncompliant with MTX.
Dr. John Cush RheumNow
5 months 3 weeks ago
“Play the game for more than you can afford to lose... only then will you learn the game.”
- Winston Churchill
Dr. John Cush RheumNow
5 months 3 weeks ago
Full read review of the Mechanistic Effects of Methotrexate in the Treatment of Rheumatoid Arthritis. https://t.co/PrMyZ7q3wX download here: https://t.co/aRnmRm770Z https://t.co/5B0mBjzOXQ
