Dr. John Cush RheumNow
5 years ago
DEA has warned of an increase in illegal counterfeit pills containing fentanyl & methamphetamine. These often look Rx opioids (Oxycontin, Percocet, Vicodin), Xanax or Adderall. DEA seized >9.5 million fake pills (more than last 2 yrs) https://t.co/Y0gJ4XrV1a
Dr. John Cush RheumNow
5 years ago
Study Finds U.S. Generic and Biosimilar Savings Totaled a Record $338 Billion in 2020 https://t.co/hPR0nGd6jp
A two-dimensional/Doppler echocardiography of rheumatoid arthritis (RA) detected premature, clinically quiescent diastolic function.
Diastolic dysfunction (DD) is known to associate with increasing age, gender (female), and hypertension; it appears some patients with RA may also be at risk.
A total of 61 RA patients and 107 healthy subjects underwent 2D-ECHO. All were premenopausal women with no history of hypertension.
A randomized controlled trial in gout patients has shown that starting febuxostat during an acute gout flare was without ill-effects and did not prolong the gouty attack.
A population based Swedish study of birth records shows that antibiotic exposure in first three years of life to be associated with a future risk of juvenile idiopathic arthritis (JIA), although infections during fetal life or childhood did not increase risk of JIA.
Dr. John Cush RheumNow
5 years ago
Biosimilar update: 31 FDA approved biosimilars, but only 60% made it to market. 2015 to 2019, drug spending grew 6.1%, biologic spending grew 14.6%; biologics are 43% of US drug spending. Most biologics at ~30% discount. https://t.co/4paYH8yVLQ
Dr. John Cush RheumNow
5 years ago
MMWR shows the safety of a 3rd (booster) dose of the mRNA vaccine to be same as the 2nd dose AEs. V-safe data on 3rd dose (n=12,591) showed local or systemic effects (79% or 74%) to be same as 2nd dose (78% or 76%) https://t.co/LcD0ARlWJ2
Dr. John Cush RheumNow
5 years ago
#RA patients had an an increased risk of mortality after CABG (HR 1.50; 1.28-1.77); and a higher risk of MI following CABG (HR 1.61; 1.28-2.04). A retrospective Finnish study comparing RA (n= 378) to nonRA patients (n = 7560) https://t.co/cGGsrLs1V2
Dr. John Cush RheumNow
5 years ago
Tymlos (abaloparatide), for the postmenopausal osteoporosis, has a label update on the MOA, now reads as: "Once-daily...abaloparatide stimulates new bone formation on trabecular & cortical bone surfaces by stimulation of osteoblastic activity." https://t.co/AC9JvtmIdZ
Dr. John Cush RheumNow
5 years ago
Case controlled study suggests that intraarticular steroid injections is associated with increased (HR 8.56; 3.29-22.3) risk of rapidly destructive hip disease (RDHD); at a rate of 5.4% (5.1 mos post injx) w/ JSN, osteolysis, fem head collapse https://t.co/grX5bO4495
Becca Brass, MD BeccaBrass
5 years ago
10 Signs You'd Make a Great Pathologist
#PathTwitter #MedTwitter
1. You've been told that you "ask too many questions" at some point in your life.
Dr. John Cush RheumNow
5 years ago
108 pts with autoimmune cytopenias (TTP, ITP, AIHA, etc) were given COVID vaccination showing low rate of post-vax flares. Signif HEME decreases in 7.4% of AIHA & ITP; mild decrease in 10% AIHA and 20% ITP, w/ no Rx change https://t.co/OaHILar57z
Dr. John Cush RheumNow
5 years ago
Variance in Uric acid? 85 pts without gout & serial SUA measured. 72/85 had nl SUA, but 21% later had high SUA x1. If SUA < 6, much less like to have future hyperuricemia (7% vs 39%, p = 0.0037). 13 w/ high SUA, half later had nl SUA. https://t.co/w05ll3OMbJ
Dr. John Cush RheumNow
5 years ago
Global SECURE-IBD trial on IBD drugs and COVID shows that severe COVID-19 outcomes were not associated with the use of biologics and mesalamine/sulfasalazine, AZA, 6MP, MTX combo Rx or biologics (TNFi, IL-12/23, IL-23, integrin inhib) https://t.co/MO4i5ngKkr
A longitudinal study from Iceland shows an increasing number of native joint infections (NJI), with iatrogenic, postarthroscopic infections being of particular concern.
