Today Lancet reported the results of another retrospective trial showing that hydroxychloroquine or chloroquine, alone or with a macrolide antibioitic, offered no additional benefits to COVID-19 patients, but was associated with higher rates of mortality and arrhythmia.
Dr. John Cush RheumNow
6 years 4 months ago
Genetic study of 57 systemic JIA children finds presence of MEFV variant p.M694V/I was a risk factor for sJIA (OR: 7.13) https://t.co/TL6WisMQo8 Other studies have shown ~31% of Still's patients at lease 1 genetic variant for periodic fever syndromes. https://t.co/8ppovEw2kt
Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com.
Dr. John Cush RheumNow
6 years 4 months ago
Metformin reduces RA risk in Women - Population study of 2.3 million, found 113749 starting metformin (1998-2014); 558 developed new RA. Adherence (PDC 40–59%) predicted lower adjusted hazard ratio = 0.62, moreso in women on 2550+ qd https://t.co/z6AWWlBpa2
Dr. John Cush RheumNow
6 years 4 months ago
Governor Cuomo cites NY study showing front line workers have lower rates of COVID positivity - Suggests that WEARING PPE's Works! (NY population 20% vs 14% transit workers & 12% healthcare workers & 10.5% NYPD and 17% FDNY/EMTs) https://t.co/pfC9rKHKVz
Dr. John Cush RheumNow
6 years 4 months ago
Review of Rheumatic Sxs with Immune checkpoint inhibitors - Common are inflammatory arthritis, PMR & myositis. Non-MSK Sxs include sicca, vasculitides and sarcoidosis. SLE and scleroderma are extremely rare. Majority can be Rx w/ steroids. https://t.co/hku5L7hypo
Lancet has reported COVID outcomes from NewYork-Presbyterian hospitals in NYC during March 2020 showing high rates of hospitalization, ICU admission, mechanical ventilation and death.
Dr. John Cush RheumNow
6 years 4 months ago
NEJM report shows that hospitalizations for acute MI are down ~-40% with the onset of the COVID Crisis (data from Kaiser N. California) - Will the shutdown/lockdown lead to other necessary services or hospital admissions? https://t.co/onpFhsDE9Z
A review of available data fails to show an increased risk of melanoma in IMID (inflammatory bowel disease, rheumatoid arthritis, and psoriasis) patients treated with systemic biologic therapies.
Dr. John Cush RheumNow
6 years 4 months ago
A patient service Video - How to Manage your Arthritis Medications (in the time of COVID) - View the video here: https://t.co/hWW0h8wCZn or listen to the podcast on iTunes or here>> https://t.co/8wV4V2pYY5 https://t.co/SldbyCBDeI
Dr. John Cush RheumNow
6 years 4 months ago
JAK inhibr safety review - Meta-analysis shows a significant 57% increase in risk of H. zoster with JAKi (RR 1.57; 1.04-2.37). Data from 82 studies, 66,159 pts w/ RA, IBD, Pso, PsA, AS. Rates of SIE=2.81/100PY and HZ=2.67/100 PY. No increase in mortality https://t.co/Tyb0VDlJOT
Dr. John Cush RheumNow
6 years 4 months ago
Specialties w/ highest percentage of women? OBGYN 58%, Peds 59%, Rheumatology 54%, Derm 49%, Endocrine 45%, Family medicine 43%, Psych 43%, Pathology 40%, IM 36%, ID 36%; yet men (375K) earn 31% more than women ($286K) as specialists https://t.co/oNTwm8vRFq
Patients with autoimmune diseases who were treated with tumor necrosis factor (TNF) inhibitors had an increased risk of developing inflammatory central nervous system (CNS) adverse events, a nested case-control study found.
Dr. John Cush RheumNow
6 years 4 months ago
Metanalysis of 9 clinical trials and 1014 patients fails to show added value of subacromial decompression surgery (for subacromial pain syndrome) over sham surgery or exercise but a small risk of harm from having surgery. https://t.co/ndJpGiLV3V
