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Metformin was given to a mouse model Sjogrens NODShiLtJ mice amp reduced salivary inflammation IL6TNFα IL17 mRNA improved salivary flow rate suppress

Dr. John Cush RheumNow

7 years 4 months ago
Metformin, was given to a mouse model Sjogrens (NOD)/ShiLtJ mice) & reduced salivary inflammation, IL-6,TNFα, IL-17 mRNA, improved salivary flow rate, suppressed effector T cells, inducec regulatory T cells & B cell diff. Why are mice so easy, SS so tough? https://t.co/yC5fJIBBEx
Heres the application for AampR Editor position 20202025 httpstcoIoyxAECAJ0

Dr. John Cush RheumNow

7 years 4 months ago
Here's the application for A&R Editor position 2020-2025 https://t.co/IoyxAECAJ0
he American College of Rheumatology invites applications for the position of Editor Arthritis amp Rheumatology for the 2020 2025 term The deadline to

Dr. John Cush RheumNow

7 years 4 months ago
he American College of Rheumatology invites applications for the position of Editor, Arthritis & Rheumatology for the 2020 - 2025 term. The deadline to submit an application is June 21, 2019.
Despite the lack of good evidence, there has been great speculation about the role of diet in causing or alleviating inflammation. Now there's new research suggesting that proinflammatory diets can increase serum C-reactive protein levels and also the risk of rheumatoid arthritis onset.
Interleukin 17 (IL-17) inhibitors are highly effective and FDA approved for use in psoriasis, psoriatic arthritis and ankylosing spondylitis. However, many of the initial trials were done in rheumatoid arthritis (RA) where it was projected to be effective, but was not. A recent metanalysis examines how effective IL-17 inhibition was in two RA populations: biologic-naïve or tumor necrosis factor inhibitor inadequate responders (TNF-IR).
UK Clinical Practice Database matched 62234 pts with and without gout showing more venous thromboembolic events in gout 0373 vs 027 per 100 Ptyrs aHR

Dr. John Cush RheumNow

7 years 4 months ago
UK Clinical Practice Database matched 62,234 pts with and without gout showing more venous thromboembolic events in gout (0.373 vs 0.27 per 100 Pt-yrs) (aHR 1.25, 95% CI 1.15–1.35) - not affected by ULT & not significant while in hospital (aHR 1.01) https://t.co/XrInEwckez
A systematic review of the medical literature shows anterior cruciate ligament (ACL), meniscus or combined ACL and meniscus injury significantly increases the risk of future knee osteoarthritis (OA). The metanalysis comprised 53 studies and nearly 1 million participants, including 185,219 with ACL injury (mean age 28 years), 83,267 with meniscal injury (mean 38 years) and 725,362 with combined injury (mean 31 years).
RheumNow Live Preview with Dr. Craig Leonardi (Psoriasis Update for Rheumatologists)
Preview of Dr. Craig Leonardi's lecture on Psoriasis Update for Rheumatologists at the 2019 RheumNow Live meeting.
Australian researchers have assessed the problem of exercise in ankylosing spondylitis (AS). After posing 10 questions to 11 experts they have provided evidence and consensus-based ecommendations on exercise in AS.
A population-based survey from South Australia shows that gout flares are common in the community and have a significant effect on health-related quality of life (HRQoL), yet there is significant undertreatment of gout, even in those on current allopurinol.
RheumNow is featuring Therapeutic Update Biosimilars in Rheumatology with video insights from several experts including Drs Alvin Wells Eric Ruderman

Dr. John Cush RheumNow

7 years 4 months ago
RheumNow is featuring "Therapeutic Update: Biosimilars in Rheumatology" with video insights from several experts, including Drs. Alvin Wells, Eric Ruderman, Vibeke Strand, Lee Simon and others. Sponsored by Sandoz, Inc.; available on RheumNow https://t.co/1vmnEJqOSi #sponsored
Prospective study of 4796 pts in the Osteoarthritis Initiative shows metformin use in obese pts BMIgt30 was Assoc with significantly less medial car

Dr. John Cush RheumNow

7 years 4 months ago
Prospective study of 4796 pts in the Osteoarthritis Initiative shows metformin use in obese pts (BMI>30) was Assoc with significantly less medial cartilage loss (0.71% vs. 1.57%/yr) & a trend towards fewer knee replacements over 6 yrs (OR 0.30, p = 0.11) https://t.co/LD0jFWtSLM
Japanese study 198 systemic sclerosis pts finds higher skin thickness scores modified Rodnan Skin Scores mRSS associated with higher risk of interstit

Dr. John Cush RheumNow

7 years 4 months ago
Japanese study 198 systemic sclerosis pts finds higher skin thickness scores (modified Rodnan Skin Scores; mRSS) associated with higher risk of interstitial lung disease (P < 0.05), restrictive LDz(P < 0.01), and diffusion impairment (P < 0.05) https://t.co/PY4n6N5Ub9
The American College of Rheumatology (ACR) Board of Directors is pleased to announce that Steven C. Echard, IOM, CAE  is the new Executive Vice President (EVP) of the American College of Rheumatology. Echard was offered the position in March of this year after a comprehensive, nationwide search that was conducted prior to announcing the departure of long-time EVP Mark Andrejeski.
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