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Proof-of-concept, open label study of 30 #GCA pts (mean age 74 yrs) Rx w/ 12 mos of weekly tocilizumab & 8wks of pre

Dr. John Cush RheumNow

2 years 10 months ago
Proof-of-concept, open label study of 30 #GCA pts (mean age 74 yrs) Rx w/ 12 mos of weekly tocilizumab & 8wks of prednisone. At wk 52 77% were in sustained pred-free remission & 23% relapsed at mean 16 wks (none w/ visual loss) https://t.co/Tbwhqs91Mf https://t.co/kZWkp5g87m
No difference in SIE/hospitalized infxn in #RA Tx w/ ABAtacept, csDMARDs or other b/tsDMARDs - from 5 data sets (2 biolo

Dr. John Cush RheumNow

2 years 10 months ago
No difference in SIE/hospitalized infxn in #RA Tx w/ ABAtacept, csDMARDs or other b/tsDMARDs - from 5 data sets (2 biologic registries, NDB, 2 claims databases). IRs per 1000PYs: ABA (16-56), csDMARDs (19-46), b/tsDMARDs (18-40). No diff in OI https://t.co/WaPUNHJb76 https://t.co/uXWe7LDLpJ
Most rheumatologists know that it is important to get pregnancy planning right for women of childbearing age living with rheumatic diseases. That is easier said than done, though: the details are difficult, it is overwhelming for the patient, and the conversations are hard.
Difficult-to-treat (D2T) axSpA seen in 88/311 axSpA pts. D2T axSpA= failure of ≥2 b/tsDMARDs (Very D2T-axSpA: same in

Dr. John Cush RheumNow

2 years 10 months ago
Difficult-to-treat (D2T) axSpA seen in 88/311 axSpA pts. D2T axSpA= failure of ≥2 b/tsDMARDs (Very D2T-axSpA: same in <2yrs). D2T had signif more periph arthritis (35 vs 21%), higher BASDAI (64 v 59) & more FM. Very D2T had more CRP, IBD, no FM https://t.co/DnxxypAEqo https://t.co/B5TxvDoYy4
Several abstracts have studied the mechanism of action of JAK inhibitors (JAKi) in various diseases. JAKi alter many other mediators affected by the JAK STAT pathway. For instance, T cell signature in blood that is proliferative was associated with a response in RA.
"The speed of our forward motion is directly related to the velocity of the people around us."
- Seth Godin
https://t.c

Dr. John Cush RheumNow

2 years 10 months ago
"The speed of our forward motion is directly related to the velocity of the people around us." - Seth Godin https://t.co/9Abzj19Hp9 https://t.co/FxitvtO6sl
Metanalysis (60 RCTs; 20,418 SpA & PsA pts Rx 17 b/tsDMARDs) shows increased NonSerious infections (RR 1.15), @highe

Dr. John Cush RheumNow

2 years 10 months ago
Metanalysis (60 RCTs; 20,418 SpA & PsA pts Rx 17 b/tsDMARDs) shows increased NonSerious infections (RR 1.15), @higher doses, longer Rx; mainly URI & ENT infxn, Signif for axSpA (RR 1.32), not PsA(RR 1.05). SIE were NOT increased https://t.co/Ab9Q9NRFu3 https://t.co/Gzoe3sRaXp
Swedish registry shows #PsA mortality risk ~11% (HR 1.11) higher than general pop., driven by comorbidity, esp in women

Dr. John Cush RheumNow

2 years 10 months ago
Swedish registry shows #PsA mortality risk ~11% (HR 1.11) higher than general pop., driven by comorbidity, esp in women (HR: 1.23) w/ longer Dz duration (HR: 1.18). Causes of death lead by CV Dz and malignancy. https://t.co/M6muM2UIkN https://t.co/az3kig9pBu
The role of thromboprophylaxis following total hip (THA) or total knee arthroplasty (TKA) is uncertain and consensus is lacking. A recent study suggests that thromboprophylaxis strategies should be tailored to individual risk of thrombosis and bleeding.
Race to the top: how high will treatment response rates in RA reach?

We have become used to the 60/40/20% rule for the

Dr. John Cush RheumNow

2 years 10 months ago
Race to the top: how high will treatment response rates in RA reach? We have become used to the 60/40/20% rule for the outcome of ACR 20/50/70 for biologics and targeted synthetic DMARDs. https://t.co/VJplM5GC31 https://t.co/gNsN3wX5tA
2023 EULAR #PMR referral recommendations:
1 Suspected/Dx pts: consider Rheum eval
2 Do full Hx+PE+Labs before referral
3

Dr. John Cush RheumNow

2 years 10 months ago
2023 EULAR #PMR referral recommendations: 1 Suspected/Dx pts: consider Rheum eval 2 Do full Hx+PE+Labs before referral 3 Refer Severe Sx PMR to rapid access 4 Defer steroids til rapid Rheum eval 5 Rheum Dx PMR w? +steroid response can be Rx by PCP https://t.co/42bL8BL3QJ https://t.co/ffpKoKXZJM
Withdraw DMARDS after remission?

Considering withdrawing DMARDs after remission is on our minds. When patients inquire

Dr. John Cush RheumNow

2 years 10 months ago
Withdraw DMARDS after remission? Considering withdrawing DMARDs after remission is on our minds. When patients inquire about tapering or stopping DMARDs while doing well, we often lack a clear-cut answer. https://t.co/mQKhwv9wCt https://t.co/Q57t63vNKe
The window of opportunity concept in RA shifted our focus to trying to treat disease earlier and more aggressively to improve long term outcomes. A natural development of this was to reconsider the possibility of therapeutic interventions aimed at the prevention of rheumatoid arthritis.
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