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Metanalysis of 26 studies (2252) pts w/ HBsAg-/HBcAb+ RA treated with b/tsDMARDs, shows the pooled HBV reactivation rate

Dr. John Cush RheumNow

2 years 11 months ago
Metanalysis of 26 studies (2252) pts w/ HBsAg-/HBcAb+ RA treated with b/tsDMARDs, shows the pooled HBV reactivation rate was 2.0% HBV reactivation higher w/ RTX (9%), ABA (6%), JAKi (1%); none w/ IL-6i or TNF-i More reactivation if pt is HBsAb- (OR=4.56) https://t.co/fSqvkEGbw3 https://t.co/WGCoZ4nQ3d
FDA Approves Infliximab Biosimilar for Subcutaneous Use

Another infliximab biosimilar has been FDA approved, but this

Dr. John Cush RheumNow

2 years 11 months ago
FDA Approves Infliximab Biosimilar for Subcutaneous Use Another infliximab biosimilar has been FDA approved, but this new version of Inflectra can be given subcutaneously for patients with inflammatory bowel disease. https://t.co/YnbisOzf0L https://t.co/9AyxEBpasb
Ph 3 360 pt RCT of sarilumab in #GCA was terminated early (COVID). 83 pts Rx'd, only 35%(29) completed. Sustained remis

Dr. John Cush RheumNow

2 years 11 months ago
Ph 3 360 pt RCT of sarilumab in #GCA was terminated early (COVID). 83 pts Rx'd, only 35%(29) completed. Sustained remission @wk 52: - SAR 200: 6/13 - SAR 150: 3/7 - PBO: 0/6 All had 26wk GC taper Sm sample size & COVID ruined RCT interpretation https://t.co/axOvJGpUti #PMR https://t.co/Xpabxn1IjZ
Subcutaneous Biosimilars?

Dr. Cush reviews RheumNow's top entries the #PMR Campaign, news, journal reports and regulat

Dr. John Cush RheumNow

2 years 11 months ago
Subcutaneous Biosimilars? Dr. Cush reviews RheumNow's top entries the #PMR Campaign, news, journal reports and regulatory actions. https://t.co/BkKFbv0I64 https://t.co/EABeZxCKYZ
Analysis of the NOR-DMARD registry and Vienna #RA cohorts provided novel definitions for an RA flare, requiring an incre

Dr. John Cush RheumNow

2 years 11 months ago
Analysis of the NOR-DMARD registry and Vienna #RA cohorts provided novel definitions for an RA flare, requiring an increase of -4.7 on the SDAI or -4.5 on the CDAI Flare definitions correlated with functional and Xray outcomes. https://t.co/f2G2nYyyWT https://t.co/JczDZa9oUf
Advancing PMR
Even though polymyalgia rheumatica is not perceived by many physicians as a severe diagnosis, its diagnosis and management actually propose significant challenges. I'd like to talk about those challenges, and what directions our path forward can include to advance our understanding and improve the treatment of patients who have PMR.
Over the past year we have implemented a fast track clinic for PMR at our institution in Dublin. Patients are referred predominantly from primary care, and we aim to see patients within a one to two week window. Without a doubt, patient outcomes are far superior with the instigation of the fast track clinic as part of our service.
JAMA Review of Knee Pain:- 5% PCP visits for knee pain:- Knee #OA: 654 mill worldwide, mostly >45 yrs age - Patel

Dr. John Cush RheumNow

2 years 11 months ago

JAMA Review of Knee Pain: - 5% PCP visits for knee pain: - Knee #OA: 654 mill worldwide, mostly >45 yrs age - Patellofemoral OA: < 40 yrs age; Sx: ant knee pain w/ squat - Meniscal tears: 12% adults < 40 yrs; dx by McMurray test & joint line tenderness https://t.co/kf1OOiwIR4 https://t.co/e5hiodDZgn

Anti-Phospholipid Antibodies - Infrequent in Certain Groups

Among patients with SLE, high titers of anti-phospholipid

Dr. John Cush RheumNow

2 years 11 months ago
Anti-Phospholipid Antibodies - Infrequent in Certain Groups Among patients with SLE, high titers of anti-phospholipid (aPL) antibodies were most prevalent in whites and Latinos and less so for Black and Asian individuals, researchers found. https://t.co/qQygcS3Ktw https://t.co/FVKlvFuuFn
Despite the official recognition of PMR as a distinct disease more than 60 years ago, patients with PMR are still largely treated with steroids (glucocorticoids, mostly prednisone). The persistent broad use of glucocorticoids in PMR is related to their quick initial efficacy in the majority of patients with PMR, their low price and the lack of alternative treatments and paucity of glucocorticoid-sparing treatments.
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