Outcomes

Health Literacy Matters in Rheumatic Disease Care Dr. Mrinalini Dey reports on abstract OP0026, "Health literacy associates with clinical, treatment and work status in people with inflammatory arthritis: Results from a national cohort", presented at EULAR 2025 in Barcelona, https://t.co/f45rxHBYnY
Dr. John Cush @RheumNow( View Tweet )
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EULAR 2025 – Day 3 Report

Jack Cush, MD

Highlights from today included presentations on imaging in vasculitis, a debate on whether to treat high risk pre-clinical RA, and EULAR Recommendations on a) Treatment of interstitial lung disease (ILD); b) Physical Activity in people with arthritis; and c) EULAR disease activity score for

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NMA of 14RCTs (>2500 pts) eval relative efficacy of bDMARDs and tsDMARDs in mostly biologic naïve nr-axSpA pts. -All therapies studied significantly improved ASAS40 response rates compared to placebo. -Certolizumab and Golimumab were the most effective therapies, followed by https://t.co/BJLRpEDYrv

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Adela Castro @AdelaCastro222( View Tweet )
In 30 axSpA pts (mean age 42 yrs, BASDAI 3.5, BASFI 2.8, BASMI 2.0, chest expansion 4.5 cm), an 8-wk individualized exercise (cardiorespiratory + trunk strength via cardiopulmonary exercise testing [CPET] & David Back Concept [DBC] devices) ↓ trunk strength deficit 14.1% & https://t.co/505cCEOzu1

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Antoni Chan MD (Prof) @synovialjoints( View Tweet )
In 4,121 SpA pts (mean age 45y; 61% male), composite scores w/ joint counts (DAPSA, DAS28, DAS44) best discriminated peripheral arthritis activity vs PGA & SJC alone. All scores had excellent construct validity; CRP weakest. Composite indices may optimize SpA assessment. https://t.co/oM97BEkkH5

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Antoni Chan MD (Prof) @synovialjoints( View Tweet )
1/3 of #ERA pts poor Outcomes despite controlled disease! 2 #RCT with T2T in early #RA #CARERA 👇 persistent impact ⬆️TJC, comorbidities ⬇️SJC, CRP, global, HAQ,  F>M ⬆️disease durat’n ▶️ ⬆️ b/tsDMARDs despite =diseaese vs others ?overRx OP0330 #EULAR2025 @RheumNow @eular_org

Janet Pope @Janetbirdope( View Tweet )

Who/When to Treat Clinically Suspect Arthralgia Dr. Jack Cush discusses risk stratification in Clinically suspect arthralgia; referencing EULAR2025 abstracts OP0004 (ALTO study) and OP0325 (long term Followup of ARRIA) https://t.co/FCO80mdHLg https://t.co/sX9u8mUoak

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Dr. John Cush @RheumNow( View Tweet )
#EULAR2025 Abstr#OP0281 Not just shredding the weight but now also the pain! Another potential benefit of GLP-1 agonists - reducing symptoms of patients with Fibromyalgia. Propensity matched analysis using TrinetX database showed reduction on opiates, fatigue and pain @RheumNow https://t.co/oh6ecJmM5e

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Md Yuzaiful Md Yusof @Yuz6Yusof( View Tweet )
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Introducing Polyrefractory RA: A New Frontier in Difficult-to-Treat RA

Jiha Lee, MD

At a EULAR 2025 session titled “What makes ‘Difficult-to-treat RA’ so difficult to treat? And what can we do?”, Drs. Paula David and Dennis McGonagle introduced the emerging concept of polyrefractory rheumatoid arthritis (RA), a term now being used to describe a subset of patients who have

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Depression and anxiety in PsA is higher and has more consequences than in general population Swedish and Danish clinical registers 23000+ PsA pts HR 1.4 specialised psychiatric out/ inpatient care vs. general pop HR for psychiatric in patient care numerically higher but ns. No https://t.co/qduMcwGK0S

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Aurelie Najm @AurelieRheumo( View Tweet )
Prediction of PsA in PSO pts: does it work? First predictive model using mainly clinical data and labs extracted from primary care Performs well in the cohort it was trained w/ but not in validation cohort. Often an issue with prediction models! Needs more granularity than https://t.co/5cVgqfd4fX

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Aurelie Najm @AurelieRheumo( View Tweet )
🔍MRI lesions in early axSpA vs non axSpA with chronic back pain: -Data from SPACE cohort -n 318 (214 axSpA vs 108 non-axSpA). -Baseline imaging (CR and MRI) and at 2y f/u -Minimal progression on CR in both early axSpA and non-axSpA CBP. -On MRI, significant increase in the https://t.co/m5YOAiFUz1

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Adela Castro @AdelaCastro222( View Tweet )
PsA asso w/ higher risk of preterm births in women Scandinavian registries 688 PsA pregnancies 8% preterm births vs. 4.5% general population OR 1.8 16.4% if bDMARD combination OR 4 3.1% if bDMARD monotherapy OR 0.7 bDMARDs combo probably a surrogate of high disease activity

Aurelie Najm @AurelieRheumo( View Tweet )

Among 200 #axSpA pts from Rheumazentrum Ruhrgebiet 🔴Performance tests (SPPB) were associated with 🔴Global functioning and health (ASAS-HI and other PROs) What does this mean? Improving physical performance could enhance PROs & QOL #EULAR2025 POS# @RheumNow @XBaraliakos https://t.co/P3Q5NDvtoj

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Nelly ZIADE 🍀 @Nellziade( View Tweet )
What's the difference between PIPsA & NIPsA? (Persistent Inflammatory confirmed by IMAGING vs. Non inflammatory PsA) 🔹️Cross-sectional study 🔹️517 pts under b/tsDMARDs 🔹️10.3% D2T 🔹️57% PIPsA / 43% NIPsA 👇 Distinct phenotypes 👇 OP0176 #EULAR2025 @rheumnow https://t.co/YGHpbeE6ws

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Nelly ZIADE 🍀 @Nellziade( View Tweet )
What happens to the prevalence of D2T PsA if we use different parameters in its definition? Data from 5 Nordic registries including 13,872 patients showed a variation from 37% (less stringent) to 0.6% (more stringent)! OP0177 #EULAR2025 @rheumnow https://t.co/QbF15t3Zrz

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Nelly ZIADE 🍀 @Nellziade( View Tweet )
🚨Diagnostic delays are real in axSpA: -Can lead to more extra-msk manfieststions (EMMs) in PsA and axSpA. -Increases disease burden and productivity losses. -EMMs can present before articular sx -Uveitis and IBD associated with longer dx delays. -Diagnosis has improved since https://t.co/rWMwG7Ewwe

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Adela Castro @AdelaCastro222( View Tweet )
A machine learning (ML) model using electronic medical record (EMR) data from 396,000 Mayo Clinic primary care patients identified undiagnosed psoriatic arthritis (PsA) with area under the curve (AUC) 79.6%. Key predictors: psoriasis, joint pain, tenosynovitis, https://t.co/VsYevnJEjK

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Antoni Chan MD (Prof) @synovialjoints( View Tweet )
In CareRA pooled analysis, 1 in 3 early RA pts had persistent impact (pain, fatigue, HAQ) despite improved inflammation. Female sex, longer symptom duration & low CRP were predictive. Pts more often escalated to b/tsDMARDs → risk of overtreatment? @RheumNow #EULAR2025 #OP0330

Mrinalini Dey @DrMiniDey( View Tweet )

Some RA-ILD is less of a worry, some is critical. How do we stratify? Great modelling work from Korea & @jeffsparks - model stratifying really well, even without KL-6. We need to do this more, so we can go really hard early when we need to. #EULAR2025 OP0329 @RheumNow https://t.co/i2djatO3F2

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David Liew @drdavidliew( View Tweet )
🌍Patients w RMDs across 🇫🇷🇳🇱🇨🇭🇹🇷 face different barriers to physical activity: 💶Cost =barrier in 🇳🇱 ⛈️Weather =barrier in 🇹🇷 🧑‍⚕️HCP support =key in 🇫🇷 🏃Active transport & knowledge =enablers in 🇨🇭 Tailored physical activity interventions needed. @RheumNow #EULAR2025 #OP0382-HPR https://t.co/lk7fwDHDe7

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Mrinalini Dey @DrMiniDey( View Tweet )
We can control inflammation in RA, but some pts still struggle with disease impact, despite improving with bDMARDs: - lower inflamm - higher comorbidities Doesn’t necessarily map to fibromyalgia dx Beyond Rx, this is the critical question CareRA/2000 #EULAR2025 OP0330 @RheumNow https://t.co/Th3smMgtVb

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David Liew @drdavidliew( View Tweet )
PsO + recent arthralgia—but no PsA. Treat or wait? 🧠 18% developed PsA in 3 yrs, most in year 1 🔍 Predictors: tender joints, disability, enthesis erosion Consider early rheum input for these patients Abstract POS0299 @RheumNow #EULAR2025

Jiha Lee @JihaRheum( View Tweet )

Can RZB deliver in real-world early PsA? 💥 9-month results say yes: ✅ Dactylitis gone in 79% ✅ Enthesitis in 90% ✅ 97% MDs & 88% pts satisfied Early intervention may pay off. Abstract POS0304 @RheumNow #EULAR2025

Jiha Lee @JihaRheum( View Tweet )

Very pleased to present at #EULAR2025 work @ArthritisAust on consumer involvement into research. Consumer involvement in research delivers: - better, more relevant research - better dissemination of results - competitiveness in today’s funding landscape POS1016-PARE @RheumNow https://t.co/0fhpsnGhdT

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David Liew @drdavidliew( View Tweet )

Recent Blogs

CNS Lupus (NPSLE)

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29 yr. old woman with SLE and transverse myelitis. Is this NPSLE; how to diagnose? Read Post

Hydroxychloroquine for Everyone

Jack Cush, MD
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Nearly 25 years ago, while lecturing on best therapies for rheumatoid arthritis (RA), I loudly stated that hydroxychloroquine was “useless” and, deservedly, I was “boo-ed” off stage. My point then was that rheumatologists needed to be aggressive, if not overly aggressive, in treating all RA patients. And my view was that HCQ was representative of under-treatment. I have reconsidered the use of HCQ in RA substantially in the last few years, based on its merit. Read Post
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