Practice

Methotrexate Safety Tips (7.31.2026)

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Dr. Jack Cush reviews the news and journal articles from this past week on RheumNow.com.

Four Decades of Gout Management

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During this month-long campaign on Gout, we have documented many significant changes in our approach to gout, as well as many unmet needs and deficiencies that merit our continued, primary attention.  We are all familiar with the famous 1905 quote, “Those who cannot remember the past

New Avacopan Analysis Sent to FDA

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After data manipulation allegations, the FDA has been calling for the vasculitis drug to be pulled from the market since January.

Amgen has submitted a third-party review of avacopan's (Tavneos) pivotal trial data and other analyses to the FDA in a bid to keep the embattled drug for

$2 Million in Research Grants for Juvenile Arthritis

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July is Juvenile Arthritis Awareness Month, and while many people think of arthritis as a disease of aging, nearly 300,000 children in the U.S. are living with a rheumatic disease.

Equally important is that 2026 marks a 50 year anniversary for Pediatric

Genetic Risk Loci in Fibromyalgia

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Researchers examined genetic data drawn from 11 different worldwide cohorts, that included from more than 2.5 million adults, of which 55,000 had been diagnosed with fibromyalgia. They identified DNA sequence variants in 26 regions of the genome that affect the risk of developing fibromyalgia.

Uricase-Targeted Therapies in Gout

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In most mammals, uricase catalyzes the oxidation of uric acid to allantoin, a highly soluble compound easily excreted by the kidneys. But humans lack functional uricase, leaving xanthine oxidase inhibitors (allopurinol/febuxostat) as first-line urate-lowering therapy (ULT). Uricase-based

The Wider Implications of Dactylitis

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Dactylitis, AKA the "sausage digit", is a hallmark of psoriatic arthritis (PsA), but as Possemato and colleagues point out, it is fundamentally a clinical sign, and not a diagnosis. This review article discusses the wider implications of dactylitis in rheumatology and medicine underscores the

Chikungunya Club Meeting (7.24.2026)

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Dr. Jack Cush reviews the news, journal reports from the past week on RheumNow.com.

Swimming Reduces Disability from Low Back Pain

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Swimming is commonly recommended for patients with chronic low back pain. Yet, there is little trial data investigating swimming. An Australian study has shown for the first time that a program of swimming can be clinically effective in reducing disability from chronic low back pain

Interferon-α as an Immunologic Driver of Sjögren's Disease

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Expert Perspective on Calcium Pyrophosphate Deposition Disease

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A recent perspective by Tedeschi tackles many unresolved issues around CPPD diagnosis, classification, and management, including the lack of clinical trials or FDA approved treatments.

Fibromyalgia: Diagnosis and Management

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Fibromyalgia (FM) affects 4–6% of the U.S. population, with nearly a 2 fold female predominance. Nociplastic pain underlies the pathophysiology of FM. CNS hypersensitization to both painful and non-painful stimuli occurs with little or no tissue pathology. Framing FM as a disorder of CNS

Seronegative RA Disease Activity (7.17.2026)

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Dr. Jack Cush reviews the news, journal articles and Gout features from this past week on RheumNow.com.

ACR: Medicare Cuts for Physicians Highlight Need for Reform

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The American College of Rheumatology (ACR) was disappointed that the proposed Medicare Physician Fee Schedule (MPFS) from the Centers for Medicare & Medicaid Services (CMS) once again included a serious cut to the conversion factor. The -1.68% cut—the sixth proposed cut in as many years—

ACP Position Paper on Dietary Supplements

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More than half of U.S. adults use dietary supplements, yet only a quarter use supplements recommended by a healthcare professional, and current law lets supplements reach the market with no premarket safety evaluation, unlike drugs or food additives. The paper notes that under DSHEA, dietary

Guidelines to Spot Cancer in High Risk Dermatomyositis

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International guidelines can help identify dermatomyositis patients with a particularly high risk for cancer, according to a retrospective single-center U.S. study.