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GLP-1 Drugs Reduce Rheumatoid Arthritis Symptoms

MedPage Today

Key Takeaways

  • Past studies have suggested that GLP-1 receptor agonists may inhibit inflammatory processes in addition to their metabolic effects./>
  • This study examined medical records for overweight/obese rheumatoid arthritis
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GLP-1 drugs cost-effective for knee osteoarthritis and obesity

EurekAlert!

A new study led by investigators at Mass General Brigham finds that adding novel weight loss GLP-1 drugs semaglutide and tirzepatide to usual care represents a cost-effective treatment strategy for people with knee osteoarthritis and obesity, with tirzepatide providing greater health benefits at

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My article 👇 summarizing the 2025 update of EULAR recommendations by @eular_org, presented by Josef Smolen at @APLAR_org https://t.co/QFWZmqm6IR @RheumNow #APLAR25 https://t.co/ctQdu8gQEO

Aurelie Najm @AurelieRheumo( View Tweet )

A self learning program to train non Rheumatologists to interpret pelvic X-rays and identify sacro-iliitis? It works, but it seems the participants were already well trained as pre test scores were already reaching 60+% Surprised to see radiologists constituting 1/4 of the test https://t.co/mRcFRSuAws
Aurelie Najm @AurelieRheumo( View Tweet )

Equal Safety of JAK Inhibitors and TNF Inhibitors

JAMA has published a systematic review and meta-analysis of head-to-head studies showing there was no meaningful difference in safety events observed when taking either JAK inhibitor (JAKi) vs TNF antagonist (TNFi) therapies for the treatment of immune-

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STOP-RA: Hydroxychloroquine Fails in ACPA+ Arthralgia

Deane et al has published the results of the STOP-RA trial, demonstrating that 12 months of hydroxychloroquine (HCQ) did not prevent the development of clinical RA at 36 months. 

The fate of Individuals elevated anti-cyclic citrullinated peptide (anti-CCP) antibodies and

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An important message from Prof. @XBaraliakos on D2M-axSpA: Re-evaluate your diagnosis & check for comorbids before labelling pts as tx-refractory or difficult-to-manage. consider other causes: FM, other causes of pain @RheumNow #APLAR25 @rheumarhyme @marklagacmd https://t.co/Lo0yShOK0P
Drivers of costs associated with economic costs of RMDs in Asia Pacific -Traditional medicine -Loss of income much higher if worker as opposed to unpaid household labor so high impact of gender roles -Impact of out of pocket health payments due to « catastrophic spendings Â» in https://t.co/sptwGE7J2V
Aurelie Najm @AurelieRheumo( View Tweet )
Update on Rheumatology workforce shortage in Asia-Pacific Date presented by Dr Ahmad Number of Rheumatologists per 100000 inhabitants across @APLAR_org countries -3 in Japan -1.3 in Australia, Hong Kong, Singapore -0.03 in Pakistan As a result: delayed diagnosis for patients! https://t.co/Hycqtp8BtY
Aurelie Najm @AurelieRheumo( View Tweet )
Is it #lupus? Interesting study by @escheriKYA et al. showing comparable diagnostic performance of SLERPI (93%) in 🇵🇭 patients vs. SLICC and EULAR/ACR criteria A practical alternative tool that can be used by clinicians in a resource-limited setting 🤔 @RheumNow #APLAR25 https://t.co/xByBkjEr3r

RheumNow Podcast – Ro, Ro, Ro52 (9.12.2025)

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. Are there benefits to diet or vegan diets? What's the effect of menopause on CTD?  Ro52 makes a big entrance with all our ILD coverage this month.

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SMART study - Single vs. Split Dose Methotrexate in RA

Split dose weekly, oral methotrexate (MTX) was shown to be superior to single dose MTX in treating active rheumatoid arthritis (RA) patients.

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Regional Disparities in DMARD Management for RA Treatment Dr. Aurelie Najm, Glasgow, reports on a session on "Updates on DMARDs treatment: global standards and regional adaptations" from the APLAR 2025 Congress in Fukuoka, Japan. https://t.co/zDo5NxKtbE https://t.co/kF9FxyWkIQ
Dr. John Cush @RheumNow( View Tweet )

PAH diagnosis and management in the context of CTD ILD

Pulmonary arterial hypertension (PAH) is a serious complication of connective tissue disorders. Approximately 25% of patients with PAH have an underlying CTD, making CTD-PAH the second most common cause of PAH. During the session on Management of Lung Complications in CTD at APLAR 2025, Prof.

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ERS/EULAR guidelines for CTD-related interstitial lung disease

The European Respiratory Society (ERS) and European Alliance of Associations for Rheumatology (EULAR) have published clinical practice guidelines for the evaluation and management of connective tissue diseases (CTD) associated interstitial lung disease (ILD) in two simultaneous publications in

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COLCHICORT Trial

The COLCHICORT trial in acute calcium pyrophosphate (CPP) crystal arthritis patients showed that colchicine was inferior to prednisone treatment and that responses were also influenced by other factors.

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Is it D2T RA or Clinical inertia? Concept introduced by Dr Kaneko, Japanese Keio RA cohort, followed for 5yrs 5% patients not fitting the D2T RA definition have MDA or HDA The drivers of persistent DA in RA: -overestimation of treatment effectiveness -avoidance of treatment https://t.co/0pkDaUFH4R
Aurelie Najm @AurelieRheumo( View Tweet )
One of the most impt updates recommended to add a bDMARD if tx target is not achieved by the 1st csDMARD (no more prognostic stratification) But, accdg to Dr. Smolen, adding a 2nd csDMARD should still be considered especially in resource-limited countries. @RheumNow #APLAR25 https://t.co/ZQiviGcrYp

Multimorbidity predicts flares in rheumatoid arthritis

A study from Olmstead county and the Mayo Clinic shows that multimorbidity  and social factors predict higher rheumatoid arthritis (RA) flares and lower remission rates.

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September to Remember (9.5.2025)

Dr. Jack Cush reviews the news and journal reports from RheumNow. This week - unemployment, diagnosing Sjogren's and a lot of ILD.

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Abatacept and Methotrexate may Lower Risk of Interstitial Lung Disease in RA

A post hoc, pooled analysis of of rheumatoid arthritis (RA) clinical trials shows those received abatacept had a lower rate of Interstitial lung disease (ILD).

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Methotrexate significantly lowers Systolic BP

Australian researchers have shown that methotrexate (MTX) has another secondary, beneficial effect by significantly lowering systolic blood pressure, and contributes to its well docuented cardioprotive effecs.

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Multi-omics, biomarkers, rheumatoid arthritis and pulmonary fibrosis

Rheumatoid arthritis (RA) is a common autoimmune disease, and approximately 30%-40% of patients develop pulmonary complications such as idiopathic pulmonary fibrosis (IPF), but the causal relationship between the two has long been unclear. A team from Taizhou Hospital in Zhejiang Province

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ACR Concerns on the Scientific Integrity at the CDC

ACR

On behalf of the American College of Rheumatology (ACR), we express deep concern over recent developments at the Centers for Disease Control and Prevention (CDC) that appear to undermine the agency’s longstanding commitment to science-based public health policy.

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Crepitus Does Not Predict Earlier/Worse OA

EurekAlert!

Young adults who experience grinding or clicking sounds in their knees post-surgery may be alarmed, but new research from La Trobe University suggests these sounds may not signal early-onset osteoarthritis. 

Knee crepitus, the sound of cracking or grinding in the knee joint is very

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