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Practice

Mixed Drinks, Mixed Results (10.30.2026)

Jack Cush, MD

Dr. Cush reviews the news and journal reports from this past week on RheumNow. This week on the podcastL hopeful guidelines for PMR; certainty about good & bad beverages in gout; mixed results in Sjogren's; non-lupus drugs saves lupus lives; and big hips sink ships in psoriatic arthritis

Peter Nash
@drpnash
Prof Cam Turtle,Sydney, ex-vivo CAR-T for oncology - 2-6 wk wait for expansion problematic, no CRS unlikely ICANS, APLAR Seoul 2026 #CAR-T #RheumNow
Dr. John Cush
@RheumNow
2024 web survey of German rheumatologists on CAR-T & T-cell redirecting therapies. 95% willing to refer pts to specialized centers; but 5% (most severe) are suitable for TCRT. Barriers cited: high costs (82%), limited experience (65%) & limited # appropriate Pts (35%). 4.86/10 https://t.co/o62uRVsIC7

Beyond Chondrocalcinosis - What’s New in CPPD Disease

Jack Cush, MD

An overview of calcium pyrophosphate deposition (CPPD) disease by Sara Tedeschi presents our evolving understanding of CPPD with advances affecting nomenclature, classification, imaging, genetics, long-term outcomes and potential future targeted therapies. This review builds on other important

The Efficacy of Ianalumab in Sjögren’s Disease

Jack Cush, MD

The NEPTUNUS-1 and NEPTUNUS-2 trials have showed that monthly ianalumab is superior of placebo at improving Sjögren’s disease activity at week 48, even though there was no significant ESSDAI response or in the change in SSSD or ESSPRI symptom scores.

Dr. John Cush
@RheumNow
Comorbidity management is subpar in Rheum. Surveys of 2213 inflamm rheum Dz pts & 140 rheumatologists. Rheums think theyre OK (71-92%) screening (HTN, OP, vaccines, CA), but pts say NOT (12=33%).Rheums agree they have no structured comorbidity screening in place (time 91%, https://t.co/mqcptziRdw
Dr. John Cush
@RheumNow
Prospective RCT of 39 refractory carpal tunnel pts (63 wrists) were injx w/ 1) US hydrodissection w/ normal saline (NS); 20 steroid injx; 3) US saline + steroid. Wk 24: Improved 86% & 90% grps 1 & 3; Saline superior to steroid; & adding steroid to NS yielded no benefit https://t.co/vCAB7Hojlo

Treat-to-Target has Excellent 10-Year Outcomes in RA

MedPage Today

Most patients with rheumatoid arthritis (RA) whose initial treatment used a stringent treat-to-target strategy in a clinical trial were in remission 10 years later, with only modest radiographic progression over that time, researchers said.

Impact of Myositis in Scleroderma Patients

Jack Cush, MD

Systemic sclerosis (SSc) may have overlap features such as myositis. When present, myositis in SSc is associated with an increased risk of cardiac involvement and a shift in mortality away from ILD towards a greater cardiac risk.

Dr. John Cush
@RheumNow
Open Evidence study of 952 008 US clinicians (556K MDs), submitted 271 million AI clinical queries over 2.5 yrs study period. MDs submitted ~371 queries/mo - 33% for Rx & 14% fo Dx. Highest use w/ young MD, oncology, hematology, Int medicine, & family medicine https://t.co/FGErefxWD5

Joint Disease in SLE Reconsidered

Jack Cush, MD

A new Frontiers in Immunology review from Ong, Wincup and colleagues, shows that lupus arthropathy is not a single uniform entity and it is biologically under-studied and clinically mismeasured, Moreover, the biology of lupus arthritis may shed light on choosing the best therapy for MSK

Dr. John Cush
@RheumNow
Lancet: A Public Health Policy Call Out for Osteoarthritis In honor of World Arthritis Day (Oct. 12th), The Lancet has published a public Health Policy report is to "outline a globally relevant roadmap to address the osteoarthritis identity problem, focusing on health policy https://t.co/XTRDJnOEGn
Dr. John Cush
@RheumNow
UK survey study of 6607 autoimmune dz pts (91% female) saw females had longer Dx delays, more HCP visits, & signif more often told their Dz attributed to psychiatric (43% vs 33%: OR 1.56) or psychosomatic causes (34% vs 21%; OR 1.87). Females had slightly more misdiagnoses (48% https://t.co/tGhiWCSPy9
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