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Valentine RNL 2025 Review (2.14.2025)

Dr. Jack Cush reviews highlights from RheumNow Live 2025 held in Dallas, TX on Feb. 8-9, 2025.

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Eric Dein @ericdeinmd B England 75% of RA pts have multi-morbidity Pts develop multi-morbidity BEFORE the onset of RA Should we have different goals: Prioritize LDA over remission in pts w multimorbidity Collaborate w PCP: one size doesn't fit all, do something better than… https://t.co/RIe7BhSgvJ https://t.co/4dVdR088XF
Dr. John Cush @RheumNow( View Tweet )
Adela Castro @AdelaCastro222 Multimorbidity in Rheumatoid Arthritis: -Affects >75% of pts -Reduces quality of life and increases mortality -Highly associated w/ D2T RA -Requires multidisciplinary care teams (PCP, specialists, case management, PT) -Management should start early… https://t.co/Sshm8CUWOA https://t.co/W9dojZT99T
Dr. John Cush @RheumNow( View Tweet )
Jeffrey Curtis @RADoctor Great talk at #RNL2025 by Dr Una Makris on managing geriatric rheumatology patients. How often do we under-treat #Rheumatoid arthritis patients with advanced therapies because we fall into the trap of ageism? https://t.co/kWLxt15n4X https://t.co/cmLjqigNol
Dr. John Cush @RheumNow( View Tweet )
Eric Dein @ericdeinmd J Curtis #RNL2025 AI Will Not Replace You - AI cannot replace human interaction, examination, procedures, interpreting guidelines for an individual, providing empathy, and facilitate good patient education Will become a tool... but not a replacement to a… https://t.co/FVe8CtcxfK https://t.co/0mXjEikN1K
Dr. John Cush @RheumNow( View Tweet )

That's not my problem - or is it? Multimorbidity in RA

Traditionally, rheumatologists have often been deferential to the non-articular concerns in RA to other providers, though these issues are often left unaddressed. What role do rheumatologists have in the management of multimorbidity in our patients?

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@RichardPAConway on PMR #RNL2025 @RheumNow PMR mimics: look for mimics in unusual/refractory cases - Suspect the mimics to avoid undertreatment or over-treatment Conway: PMR is NOT easy. Easy to misdiagnosis, easy to mistreat. "One of our most challenging cases" https://t.co/WqPWwCuutF
Eric Dein @ericdeinmd( View Tweet )
TheDaoIndex @KDAO2011 Potential uses of #AI for #RA -office workflow (scribe, triage) -research (match eligible pts for trials) -help with diagnosis (and likelihood of risk) -consume guidelines for disease mgmt @RADoctor #RNL2025 https://t.co/k2nOytpKBH https://t.co/7Y2OvBv9pP
Dr. John Cush @RheumNow( View Tweet )

Obinutuzumab Efficacy in Active Lupus Nephritis

A phase 3, randomized controlled trial of an anti-CD20 monoclonal antibody, obinutuzumab, was shown to be effective and safe in patients with active lupus nephritis.

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The ‘dark’ side of #Hidradenitis #suppurativa 👇 Smell of leaking lesions #HS ⬆️skin folds, buttock, axilla, also thighs, neck ⬆️depression @RheumNow #RNL2025 ‘ If pt doesn’t get in gown then not ready for systemic #Rx!’ Jennifer Clay #ClinicalPearl https://t.co/tZzz5tielt
Janet Pope @Janetbirdope( View Tweet )
Full read review and overview of Fibromyalgia - manifestations, pathophysiology, treatments and guidelines. Multidisciplinary, patient-centered treatment should includes a combination of pharmacological and nonpharmacological options. https://t.co/x4OVeQ5RJz https://t.co/i1fD6XQbnx
Dr. John Cush @RheumNow( View Tweet )
Importance of not over-relying on lab tests. We can test for what we can test for, but this is not comprehensive. For me in clinical practice - Postive antibodies can confirm diagnosis of DM but negative cannot exclude it. @RheumNow #RNL2025 https://t.co/Kyfzne4BSD
Richard Conway @RichardPAConway( View Tweet )
QD Clinic - dsDNA without Lupus Insufficient Sxs to Dx SLE, but persistent dsDNA positivity - what to do? Features Dr. Jack Cush. QD Clinics - lessons from the clinic, sponsored by RNL2025 in Dallas, TX; Feb 8 & 9, 2025 Register at https://t.co/2dcFVgu8z6https://t.co/hCXRhTJB7G https://t.co/y3Tzh5bRLJ
Dr. John Cush @RheumNow( View Tweet )
Some pearls from RA POD at #RNL2025 -What do rheumatologists want from AI: Right drug for right patient, improving documenting in less time and possibly include multimorbidity management? -Utilize AI as enhancer not replacement of the physician. AI must be trained well in a… https://t.co/9YNmeVx4t6

Adela Castro @AdelaCastro222( View Tweet )

J Curtis #RNL2025 @RheumNow AI Will Not Replace You - AI cannot replace human interaction, examination, procedures, interpreting guidelines for an individual, providing empathy, and facilitate good patient education Will become a tool... but not a replacement to a good clinician https://t.co/qPcNOjWepi
Eric Dein @ericdeinmd( View Tweet )
QD Clinic - New Palmoplantar Psoriasis and PsA New Onset Palmoplantar PsO and PsA - what are the options? Features Dr. Jack Cush. QD Clinics - lessons from the clinic, sponsored by RNL2025 in Dallas, TX; Feb 8 & 9, 2025 Register at https://t.co/2dcFVgu8z6https://t.co/3ubBL6HVGF https://t.co/Zdd6Dih5eZ
Dr. John Cush @RheumNow( View Tweet )

Drug Naming Games (2.7.2025)

Dr. Jack Cush reviews the news, regulatory and journal reports from the past week on RheumNow.com.

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Granzyme - a major driver of inflammatory & autoimmune diseases

EurekAlert!

Our immune system is armed with an array of defenses designed to detect and eliminate harmful threats. One of its most powerful defense mechanisms is the complement system—a group of proteins that patrols our body, ever vigilant for signs of infection or injury. Now, over 100 years after the

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Cannabis Hospitalizations and Mortality Risk

A Canadian population, retrospective cohort study shows individuals needing hospital-based (emergency department or hospitalization) care for a cannabis use disorder (CUD) were at increased risk of death. 

Cannabis use disorders (CUD) are associated with

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QD Clinic - dsDNA without Lupus Insufficient Sxs to Dx SLE, but persistent dsDNA positivity - what to do? Features Dr. Jack Cush. QD Clinics - lessons from the clinic, sponsored by RNL2025 in Dallas, TX; Feb 8 & 9, 2025 Register at https://t.co/2dcFVgu8z6https://t.co/ov8THqrPyC https://t.co/jmtqxcWzJ0
Dr. John Cush @RheumNow( View Tweet )
QD Clinic - New Palmoplantar Psoriasis and PsA New Onset Palmoplantar PsO and PsA - what are the options? Features Dr. Jack Cush. QD Clinics - lessons from the clinic, sponsored by RNL2025 in Dallas, TX; Feb 8 & 9, 2025 Register at https://t.co/2dcFVgu8z6https://t.co/HZZuDvga58 https://t.co/wWKhnIECwB
Dr. John Cush @RheumNow( View Tweet )

ACR Commends Legislation Addressing Harmful Medicare Payment Cuts to Physicians

ACR

The American College of Rheumatology (ACR) applauded the bipartisan introduction of the Medicare Patient Access and Practice Stabilization Act of 2025, legislation to fully offset the harmful 2.8% cut in the Medicare Physician Fee Schedule (MPFS). The bill, led by Representatives Greg Murphy

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Is Rheumatoid Arthritis Becoming Milder?

A 24 year, prospective study analyzing very early rheumatoid arthritis (RA) in three consecutive eras suggests that RA has evolved since 2005, demonstrating less seropositivity, inflammation, and erosions but is characterized by more comorbidity, smoking and corticosteroid use.

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Pain Management in Rheumatoid Arthritis

BMC has published a full read literture review of pharmacological pain management in rheumatoid arthritis, pointing out that the best evidence for pain control comes from the use of DMARDs and treat-to-target strategies.  In contrast, there is widespread use of analgesics in RA,

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BSR Guideline on Management of Sjögren disease

The British Society for Rheumatology has published its guideline for the management of adult and juvenile onset Sjogren's disease. 

This guideline is an update to the 2017 guideline and is based on medical literature review focused on 19 clinical questions. While most of the

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