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Autoimmunity Rising in Expectant Mothers

Lancet Rheumatology has published a UK study showing a significant increased in the number of expectant mothers beginning their pregnancies with autoimmune conditions.

The MuM-PreDiCT project run by the University of Birmingham, analyzed the electronic healthcare records from

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Moneyball Rheumatology (5.30.2025) Dr. Jack Cush reviews the book/movie, "Moneyball" and a suggests moneyball strategy is needed to find next level responses for our patients. https://t.co/c79y9UNTcQ https://t.co/at7mDderOP
Dr. John Cush @RheumNow( View Tweet )

Methotrexate Fails in Knee Osteoarthritis

MedPage Today

We'll be blunt: methotrexate flopped in a randomized placebo-controlled trial among patients with osteoarthritis (OA) of the knee.

Contrary to results from a previous trial in hand OA, the old-line disease-modifying anti-rheumatic drug (DMARD) failed to bring any improvement relative to placebo

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Review of ARF & Post-streptococcal reactive arthritis (PSRA) following Group A strept infxn. Early Dx & Rx of Strept can prevent ARF & PSRA. PSRA is a sterile arthritis, bimodal age onset, lower extrem arthritis, usually resolves without lasting sequelae https://t.co/ld208yf0Zk

Dr. John Cush @RheumNow( View Tweet )

Type 2 SLE: Insights from a Biopsychosocial Framework

Many of the common symptoms of lupus - fatigue, nociplastic pain, brain fog - can be invisible and difficult to measure, and can often co-occur with impaired sleep, depression and anxiety. These symptoms have led to a well described discordance between physician and patient perception of lupus

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Denosumab and Osteoporosis - A JAMA Review

An overview of denosumab use in osteoporosis (OP)  by Bauer and Ensrud was published in JAMA. 

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QUOTES TO LIVE BY: "it took me a long time be a good listener and be comfortable with silence. Its important to not just throwing facts back to patients who are suffering. Sometimes pausing is powerful. Its all about establishing relationships " - Dr. Len Calabrese https://t.co/wcKX8nTa2o
Dr. John Cush @RheumNow( View Tweet )
Hydroxychloroquine: Are Your Patients Taking It? Dr. Nathalie Costedoat-Chalumeau dives into monitoring HCQ levels and what they tell us about patient adherence. 💡Learn how to spot non-compliance early. 👉 Now live on RheumNow: https://t.co/KPjyCrMTBr #LupusCare https://t.co/vRASCc9kB0
Dr. John Cush @RheumNow( View Tweet )
Turkish study of 1263 primary care referrals to rheumatology found 35.7% with inflammatory rheumatic Dz (IRD), 17.7% osteoarthritis, and 11.2% regional pain syndromes. Another German study showed low risk of IRD if CRP <5 https://t.co/v5qYb7c7jP https://t.co/iq4NfcC3cH https://t.co/RQan6rQi8a
Dr. John Cush @RheumNow( View Tweet )
Lancet viewpoint on early imaging in axial SpA. Over-reliance on BM edema = incr in misDx. Newer tech (high-res sequences, quantitative MRI, radiomics, artificial intelligence) may improve Dx precision. Remember the SI is susceptible to mechanical stress https://t.co/E80GyQGIM0 https://t.co/egIhNP17pQ
Dr. John Cush @RheumNow( View Tweet )

Moneyball Rheumatology (5.30.2025)

Dr. Jack Cush reviews the book/movie, "Moneyball" and a suggests moneyball strategy is needed to find next level responses for our patients.

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2024 ACR Lupus Nephritis Guidelines: The Controversies Drs. Maria Dall’Era & Michelle Petri discuss the sticking points in the latest lupus nephritis recommendations. 🗣️ Insightful, honest, and essential for your practice. 📍Full update on RheumNow: https://t.co/KPjyCrMTBr https://t.co/VoOslSqs99
Dr. John Cush @RheumNow( View Tweet )

Belimumab in SLE with Mucocutaneous or Vasculitis Findings

A post hoc analysis of a belimumab (BEL) inn systemic lupus erythematosus (SLE) study showed lupus mucocutaneous and vasculitic manifestations improve with BEL and standard care.

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Valves Gone Wild in SLE

Lupus valvulitis is a rare cardiac manifestation of active systemic lupus erythematosus (SLE) and is defined by inflammation of one or more cardiac valves. It is often associated with Libman-Sacks endocarditis, which is characterized by the presence of sterile vegetations on the heart

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Biologics in Pregnancy Patients With Autoimmune Disease A large cohort, claims data study shows that among pregnant women receiving biologic therapies for autoimmune conditions, 72% continued their biologics pregnancy, more so among inflammatory bowel disease (IBD) patients https://t.co/fjtUNaYtp9
Dr. John Cush @RheumNow( View Tweet )

Genetic Link to CPPD

EurekAlert!

In a first-of-its-kind genome-wide association study (GWAS) researchers have discovered two genes, RNF144B and ENPP1, that cause calcium pyrophosphate deposition (CPPD) disease in Americans of European and African descent. This crystalline arthritis is caused by calcium

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2025 ACR Guideline for the Treatment of SLE

The ACR has released its 2025 Systemic Lupus Erythematosus (SLE) treatment guidelines and consensus-based good practice statements, applicable to children and adults with SLE. 

Overall, the goals of SLE management are to achieve remission or a low level disease activity, reduce

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IMPACT Study - Certolizumab Efficacy in APS Pregnancies

A pilot trial assessed the safety and value of tumour necrosis factor α inhibitor treatment with certolizumab in patients with high-risk pregnancies with antiphospholipid syndrome (APS
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Lupus Clinical Slides: Set 1 https://t.co/zFQqHfl8Ch https://t.co/kvVNAS17ec
Dr. John Cush @RheumNow( View Tweet )
T2T in #SLE Lots of #rheumatologists do NOT do a validated measure so #DORIS remission may be over estimated But great algorithm for #lupus #Rx ⁦@RheumNow⁩ #LUPUS2025 https://t.co/mGoopRtK2F
Janet Pope @Janetbirdope( View Tweet )

Diagnosing Neuropsychiatric SLE (5.23.2025)

Dr. Jack Cush reviews the news and journal reports from RheumNow.com - including views on the vagus nerve, NPSLE and CAR-T mania.

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‘Oranges & green vegetables’ ⬆️ #diarrhea in #MMF said Ana Malvar bad #LN outcomes if #nonadherent Good relationship with#HCP helps #adherence ✅education to help deal with side effects pts need to know Why this Rx ?how long S|E Rx #ClinicalPearl #LUPUS2025 @RheumNow https://t.co/RnFGwJSl1F
Janet Pope @Janetbirdope( View Tweet )

Shifting the Management Paradigm for SLE and Lupus Nephritis

The paradigm for treating patients with systemic lupus erythematosus (SLE) is rapidly shifting and our patients will surely benefit with improved outcomes.

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Lupus Clinical Slides: Set 1 https://t.co/zFQqHfl8Ch https://t.co/MBzsixwhQc
Dr. John Cush @RheumNow( View Tweet )

No Cancer Recurrence with Biologic DMARDs in RA

A prospective Danish rheumatoid arthritis (RA) registry study look at the risk of recurrence when a biological disease-modifying antirheumatic drugs (bDMARDs) was ued in patients with a a prior solid cancer (in remission) and found no increased

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