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IBS in America

Despite advances, IBS remains a burden for many millions. A new AGA-sponsored survey conducted by The Harris Poll, a Stagwell (STGW) agency, reveals that IBS symptoms disrupt patients’ productivity and personal activities 19 days each month, impacting both personal and professional

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Repurposing & Pipeline (8.8.2025)

Dr. Jack Cush reviews the news, reports, pipeline and drug repurposing on this week’s podcast.

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Dermatomyositis Reviewed

Researchers from the University of Pennsylvania have published an open-access review of dermatomyositis (DM) - its manifestations, hallmark cutaneous features, etiopathogenesis and treatment options.

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Inefficiencies of ANA Testing

The Journal of Rheumatology has published an analysis of antinuclear antibody (ANA) multiplex testing showing its nonspecific utility and poor rate of return in identifying ANA-associated autoimmune rheumatic disease (ARDs).

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Rheums Speak - RA Treatment Survey RheumNow's August 2025 “Live Vote” surveys will examine Rheumatologist impressions, knowledge and practices over the last 20 years when treating rheumatoid arthritis. https://t.co/hJSQ5mMJ6b https://t.co/466wOjTSGS
Dr. John Cush @RheumNow( View Tweet )

Smoking and the Global Burden of Rheumatoid Arthritis

Detailed analysis of the Global Burden of Disease (GBD) 2021 database shows that tobacco and smoking is one of the most significant environmental risk factors for Rheumatoid Arthritis (RA) over the last 20 years. 

This study utilized the Global Burden of Disease

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RA leads to ILD: but ILD does not lead to RA

Rheumatoid arthritis is a common autoimmune disease, and approximately 30%-40% of patients develop pulmonary complications such as idiopathic pulmonary fibrosis (IPF), but the causal relationship between the two has long been unclear.

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Survey of 39 Spanish rheumatologists (mean age 50 yrs, 9.6 yrs in practice) finds that while 79% agreed on the importance of using Patient-Reported Outcome Measures (PROMs), only 28% use them routinely (mostly pain, VAS, HAQ) - reason? Time! https://t.co/YnZBXlK24M https://t.co/a8W52XO8jh
Dr. John Cush @RheumNow( View Tweet )

Juvenile Idiopathic Arthritis - NEJM Review

Sandborg et al. has published an overview of juvenile idiopathic arthritis (JIA) - its classification, biology, genetics, , clinical presentations and treatment advances in the New England Journal of Medicine (NEJM).

JIA is the most common form of inflammatory arthritis in the pediatric

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RHEUMATOLOGIST Survey: How has your career/practice evolved in the last 20 years? Click here>>https://t.co/wyKkdUQclz a. just getting started… b. More research &scholarship c. Growing a successful practice d. Greater knowledge and expertise e. Closer to burn-out

Dr. John Cush @RheumNow( View Tweet )

RHEUMATOLOGIST Survey: How has your career/practice evolved in the last 20 years? Click here>>https://t.co/wyKkdUQclz a. just getting started… b. More research &scholarship c. Growing a successful practice d. Greater knowledge and expertise e. Closer to burn-out

Dr. John Cush @RheumNow( View Tweet )

Rheums Speak - RA Treatment Survey

RheumNow's August 2025 “Live Vote” surveys examine Rheumatologist impressions, knowledge and practices over the last 20 years when treating rheumatoid arthritis.

The first survey on RA Treatment (7/28/2025) sheds light on evolving prescribing habits, use of biologics, and key frustrations in RA

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Aging Quiets Lupus

EurekAlert!

UCSF researchers have found that epigentic changes in interferon genes over time may lead to lupus being less active as they age. Lupus is a “classic” autoimmune disease. It causes the immune system’s first-line viral defenses — known as interferons — to attack the body. Nearly every organ is at

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Top 20 Best Rheumatology Hospitals - 2025 Each year, U.S. News ranks hospitals in 15 specialties and for the 8th year in a row Johns Hopkins Hospital in Baltimore has been named the top hospital for rheumatology by U.S. News & World Report. https://t.co/gBA49giwX7 https://t.co/sObhLxgrBf
Dr. John Cush @RheumNow( View Tweet )

A New RA Approval (8.1.2025)

Dr. Jack Cush reviews the news, journal reports and a new treatment for RA from the FDA.

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Rheumatology Salaries Remain Low The annual Medscape Physician Compensation report was published and shows only modest salary gains for most specialists. https://t.co/NcmwrMxpKr https://t.co/mxFbqtUQv2
Dr. John Cush @RheumNow( View Tweet )
CARRA registry study of 2,956 JIA pts (activity: 71% inactive/minimal, 25% persistent moderate/high, 2% “improving”, 2% “flaring”). In 12 mos, Only 10% had DMARD escalation & only 15% escalation despite 2 consecutive visits w/ persistent moderate/high disease activity. This is https://t.co/Gviwgfcdrk
Dr. John Cush @RheumNow( View Tweet )

FDA Approves Vagal Nerve Stimulator for RA

SetPoint Medical announced that the FDA has approved the company’s SetPoint System, a first-in-class neuroimmune modulation innovation for treatment of moderate-to-severe rheumatoid arthritis (RA) for those who are not adequately managed by—or cannot tolerate—existing advanced RA therapies, such

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Options for Refractory axSpA or PsA

MedPage Today

Although most patients with axial spondyloarthritis (axSpA) or psoriatic arthritis (PsA) didn't respond adequately to the interleukin-17 (IL-17) inhibitor ixekizumab (Taltz), enough did that it should still be considered in such cases, a Danish registry study indicated.

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Rituximab is not Superior in EGPA

A cohort study of Eosinophilic Granulomatosis With Polyangiitis (EGPA) patients from the French Vasculitis Study Group failed to show superiority of rituximab compared to conventional strategy with glucocorticoids (GS) alone or in combination with cyclophosphamide.

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Factors Affecting Biologic Use in Rheumatoid Arthritis A San Francisco Rheumatoid Arthritis Panel cohort survey between 1999–2011, showed numerous sociodemographic, disease, and health characteristics that influenced the initiation of treatment with biologic agents for https://t.co/azDYk6saHN
Dr. John Cush @RheumNow( View Tweet )
Cancer screening in RA - retrospective, matched cohort study of 1,614 RA vs 1,597 controls (mean 63 yrs); @ 5 yrs, RA had less cervical cancer screens (52% vs 58%) (aHR:0.83); but no decrease in screens for breast (aHR:0.98), prostate (aHR:0.99), or colorectal (aHR:1.04) CA https://t.co/NnxRnZcZwq
Dr. John Cush @RheumNow( View Tweet )

Rheumatology Salaries Remain Low

The annual Medscape Physician Compensation report was published and shows only modest salary gains for most specialists.

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Top 20 Best Rheumatology Hospitals - 2025

U.S. News & World Report has published its Best Hospitals for 2025, listing the best among many specialties, including rheumatology.  Each year, U.S. News ranks hospitals in 15 specialties and for the 8th year in a row, Johns Hopkins Hospital in Baltimore has been named the top hospital

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HCQ Preserves Renal Function in Lupus Nephritis

MedPage Today

Lupus nephritis patients on long-term therapy with hydroxychloroquine showed significantly less decline in renal function, compared with patients treated otherwise, a 10-year retrospective study indicated.

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