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Abuse of the Safety-Net 340B Drug Programs Dr. Madelaine Feldman comments on the 340B Drug Pricing Program, a safety-net initiative designed to provide costly therapies to vulnerable populations. She argues that the program has deviated from its original intent, with certain… https://t.co/5rIQHsIeAS https://t.co/rXwQPctHDf
Dr. John Cush @RheumNow( View Tweet )

Best of 2024: Prescription Painkiller Misuse in Chronic Pain Patients

EurekAlert!

A new scientific review of 148 studies enrolling over 4.3 million adult chronic pain patients treated with prescription opioid painkillers has found that nearly one in ten patients experiences opioid dependence or opioid use disorder and nearly one in three shows symptoms of dependence and

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Abuse of the Safety-Net 340B Drug Programs

Dr. Madelaine Feldman has written an important commentary on the 340B Drug Pricing Program, a safety-net program that would allow vulnerable populations to receive expensive new therapies. But she points out that "this well-intentioned program has strayed from its original purpose", allowing

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Tocilizumab Efficacy in Giant Cell Arteritis Phenotypes

A Spanish Collaborative Group study of Tocilizumab (TCZ) in Giant Cell Arteritis (GCA) demonstrated high efficacy regardless of the different vascular phenotypes treated. 

Multicentre study of 471 GCA patients treated with TCZ, assessed outcomes according to vascular

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Biosimilars Do Impact Biologic Drug Costs

MedPage Today

Introduction of biosimilars for the rheumatology drug adalimumab, whose original branded version Humira has long been a blockbuster, appears to have led to a dramatic drop in net spending for these products -- even though biosimilars barely dented Humira prescription rates.

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54K Peptic Ulcers Annually (12.13.2024)

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com

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Chikungunya marches on, at a cost A recent article from BMC Global Health suggests that between 2011 and 2020, the mosquito-borne disease chikungunya, has disabled millions and likely amassed close to $50 billion in healthcare and disability-related costs in 110 countries.… https://t.co/TnDObv1obT https://t.co/yjMeBODuFv
Dr. John Cush @RheumNow( View Tweet )

Treat-to-Target LLDAS in Lupus

MedPage Today

Patients with highly active systemic lupus erythematosus (SLE) appeared to sustain much less organ damage and fewer disease flares when drug therapy yielded substantial relief, researchers found.

Unfortunately, only a minority of such patients achieved low disease activity or remission

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Don’t Buy Guitars (12.6.2024)

This year at ACR24, the RheumNow faculty and reporters were prolific, generating >800 Tweets, 56 written articles, 117 Videos and 28 podcasts – all in 4 days! You can best review and learn ACR24 by A) Rheumatology Roundup; b) Topic Panel videos; and c) Topic podcasts.

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Osteoarthritis (OA) affects 53.2 million in the USA & is projected to rise significantly by 2040. Societal costs are $132 billion ($11,00 per/pt). OA is the 3rd most rapidly rising disability, behind diabetes and dementia. https://t.co/n3Rwjjsio3 https://t.co/FPDWd6gEpi
Dr. John Cush @RheumNow( View Tweet )
What factors are assoc with uptake of newer meds in RA? ➡️Incr use of b/tsDMARDs over 10yrs ➡️Use of newer drugs lower in older ppl, socioeconomic deprived & Asian/Black ppl Could this indicate disparities in access to meds? How can we best address this? Ab2608 #ACR24 @RheumNow

Mrinalini Dey @DrMiniDey( View Tweet )

US biosimilar exp Interchangeable biosimilar - can substitute for reference product wo consulting MD Primary endpt: pharmacokinetic data 61 approved biosimilars @RheumKay: “pts should share in financial benefits” Currently 5-87% discount #PBMReform @ACRheumDC @RheumNow #ACR24 https://t.co/RqwbZalZko
Eric Dein @ericdeinmd( View Tweet )
Biosimilar switching in practice Hyrich: UK experience Switching to biosimilar has no immediate benefit to patients but saves NHS money Allows for gain share that can be re-invested in pt care Transparency in switching in explaining to pts and offering resource @RheumNow #ACR24

Eric Dein @ericdeinmd( View Tweet )

A call for ANA stewardship? Abstract 1931: Educating clinicians on wise ANA ordering via EMR Alert plus removing the comprehensive ANA panel --> - ↓ ANA testing (outpatient 15.9%→7.4%, inpatient 25.5%→6.4%) ↓ costs ($440k→$130k) #ACR24 @RheumNow

Akhil Sood MD @AkhilSoodMD( View Tweet )

Biosimilar changes ASP outpacing reimbursement making not affordable to use Working with CMS but needs further legislation to fix this FDA may change interchangeability status for medications to no longer require switching studies @ACRheumDC @RheumNow #ACR24 https://t.co/daYQJvsHRG
Eric Dein @ericdeinmd( View Tweet )
@ACRheumDC State Update: No changes at executive level Some shifts in state legislation With political changes and new administration, states will probably take larger role in healthcare legislation - PBM reform, copay accum, prior auth/step, reprod healthcare @RheumNow #ACR24 https://t.co/jc77HCLxqQ
Eric Dein @ericdeinmd( View Tweet )
@LennMcD @ACRheumDC Many ACR priorities in bills, needs to be passed in law Victories: Incr NIH biomedical research funding, added to DoD funds Medicare reimbursem and telehealth needs addressed by lame duck congress Get involved, reach out, write letters @RheumNow #ACR24 https://t.co/7oCvUFWpx4
Eric Dein @ericdeinmd( View Tweet )
Biosimilar Slow Growth in USA A recent Forbes article, "Biosimilars Are Making Inroads In U.S., But It’s Still A Bumpy Ride", reviews the current state and reasons for slowish uptake of these significant cost-savings alternatives to biologic therapy in treating cancer and… https://t.co/yO3tUVk2jj https://t.co/ft6gqpnWMx
Dr. John Cush @RheumNow( View Tweet )

Early RA Journey - Patient Perspectives and Uncertainties

Canadian early RA (ERA) patients were interviewd to depict their perspectives from onset and diagnosis to referral and care. This report highlights the importance of patient pain and primary care physician (PCP) intake and referral. PCP and HCP delays in referral to a specialist still exist.

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Biosimilar Slow Growth in USA

A recent Forbes article, "Biosimilars Are Making Inroads In U.S., But It’s Still A Bumpy Ride", reviews the current state and reasons for slowish uptake of these significant cost-savings alternatives to biologic therapy in treating cancer and autoimmune disorders. The following are takeaway

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Dr. Quotes (11.8.2024)

Dr. Jack Cush reviews the news and journal reports from this past week from RheumNow.com.

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EULAR Review of Lifestyle Improvements for Rheumatic Patients

A EULAR taskforce has evaluated the effect of lifestyle behaviors in rheumatic and musculoskeletal diseases (RMDs) and concluded that there is moderate evidence for a small benefit for certain dietary components, but overall, high-level evidence regarding dietary exposures on outcomes in RMDs is

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Should They Put Off Hip Replacement Surgery?

The NEJM reports what should be obvious to rheumatologists: that older adults with severe hip osteoarthritis should opt for total hip replacement (THR) over conservative exercise measures as THR yields a clinically important improvement in pain and function.

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Medscape 2024 Medical Student Experience Survey

Medscape has published a survey overview of US Medical Student impressions and experiences, satisfaction, what they think of their education and how prepared are they for the USMLE (boards) and residency.

The survey was done between march and June 2024 and included 768 US medical

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SGLT2 Inhibitor Protective Effects in Lupus

Systemic lupus erythematosus (SLE) outcomes were assessed based on whether they received sodium-glucose co-transporter 2 inhibitors (SGLT2i), in the setting of comorbid type 2 diabetes (T2D).

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