Notch and TGFβ Signaling in Refractory Rheumatoid Arthritis

Save

Spatial transcriptomic profiling of rheumatoid arthritis (RA) synovial biopsies (pre- and post-treatment) has revealed new insights into the pathobiology or treatment resistent RA. 

TOPKAT Trial: Partial vs Total Knee Replacement

Save

Patients with osteoarthritis (OA) primarily affecting only one knee joint compartment did just as well with partial knee replacement (PKR) as with total arthroplasty after 10 years in a randomized trial -- and maybe a little bit better.

DMARD Responses in Localized Scleroderma

Save

JAMA Dermatology has published the results of a juvenile localized scleroderma (JLS) trial showing that mycophenolate mofetil (MMF) and methotrexate (MTX) are equally effective in treating JLS, noting low flare rates and possibly better tolerability with MMF.

B Cells at the Brink in Sjögren Disease

Save

The current issue of Arthritis & Rheumatology reviews current understanding of the immunopathogenesis of Sjögren disease (SjD) and how that has influenced the quest for drug development for this most systemic autoimmune disorder. 

Consensus on Managing Vertebral Fractures in Advanced CKD

Save

A coalition of leading international experts have released the first comprehensive Consensus Statement on the Management of Vertebral Fractures in Chronic Kidney Disease (CKD) Stages G4–G5D.

Treat-to-Target in Gout and Cardiovascular Outcomes

Save

Trends in Rheumatoid Arthritis Mortality

Save

A recent study examines trends in rheumatoid arthritis (RA)-related mortality among U.S. postmenopausal women (aged 55 and older). They found RA mortality rates have declined, yet disparities in who is most affected persist, especially for white women, and those over 85 yrs of age.

Reduced Healthy Working Life Expectancy with Arthritis

Save

Using the long-running, U.S.-based Health and Retirement Study (HRS), which enrolls people age 50 and older, as the data source, Ross Wilkie, PhD, of Keele University in Staffordshire, England, and colleagues estimated that those reporting an arthritis diagnosis could expect just 6.18 more years of being able to work without physical limitations, compared with 11.71 years for those without arthritis.

Assess Reproductive Health in SLE Clinic Visits

Save

Due to the complexity of SLE, rheumatology providers should take an active role in assessing reproductive health, providing education on how SLE may affect pregnancy, and taking a collaborative, multidisciplinary approach with the patient’s gynecologist.

Emergencies, Independence & Hemorrhage (1.23.2026)

Save

Dr. Jack Cush reviews the news and reports from the past two weeks on RheumNow.Com

BIOBADASER III Registry shows No Cancer Risk with b/tsDMARDs

Save

APPIPRA Study - Benefits of Early Treatment

Save

Treating people who are at high risk of rheumatoid arthritis (RA) can delay the onset of the disease for several years, with benefits also continuing well after treatment has stopped.