Venom Peptide-Steroid Conjugate Effective in Collagen Induced Arthritis

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Science Translational Medicine features a report from the Fred Hutchinson Cancer Research Center showing that a scopion venom peptide, coupled to steroid, can significantly reduce joint inflammation in a rat model of rheumatoid arthritis (RA).

Updates on Psoriatic Arthritis at ACR 2018

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I think 2018 was the year that belonged to psoriatic arthritis (although some may argue in favor of immune conditions induced by Checkpoint inhibitors). Many years ago the late Professor Verna Wright in Leeds (UK) was a lone voice for many years describing the clinical subtypes of Psoriatic arthritis as something distinctive from rheumatoid arthritis. For a long time we thought that the treatments for PsA were just the same as RA since we were treating the same problem of synovitis.

Drug Interactions with Cannabinoids

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Cannbinoids are widely available and used for a variety of indications, but little is known about their safety and their potential for drug interactions. The Canadian Medical Journal has published a review of drug interactions with cannabinoids, many of which are mediated by cytochrome-P450 metabolism.

Airway Inflammation Drives Rheumatoid Risk

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A cohort analysis of the Nurses' Health Study suggests that asthma and COPD are associated with increased risk for incident rheumatoid arthritis (RA), independent of smoking- thus airway inflammation may be an important factor in the evolution of pre-cllnical RA.

Don't Blame the Weather in Sjogren's

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Seasonal variations in symptoms -- commonly reported by patients with rheumatic diseases -- were not observed in a large cohort of patients with primary Sjogren's syndrome, French investigators found.

Folate Levels Protect from CV Mortality in RA

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In a study of rheumatoid arthritis (RA) patients, JAMA reports that serum folate level of greater than 4.3 ng/mL was associated with lower CV mortality risk.

Interleukin-37 Targeting in Gout

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The Annals of Rheumatic Disease reports that interleukin- 27 (IL-37) may play an important role in the pathogenesis of gout, paving the way for future therapy with recombinant IL-37 in gouty arthritis.

RheumNow Podcast- Methotrexate Mechanisms (2.28.20)

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Dr Jack Cush Reviews the news and journal articles from the past week on RheumNow.com

Fatigue Looms Large in Lupus

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Fatigue is an important component of the disease experience in systemic lupus erythematosus (SLE), and can have a profound impact on patients' perception of well-being, Italian researchers reported.

Why You Should Come to RheumNow Live March 13th

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RheumNow Live kicks off its second annual meeting - a little, big meeting in Fort Worth - in just 2 weeks and I think you should be there.

Bariatric Surgery Improves Rheumatoid Activity

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Obesity is a risk factor for the onset of rheumatoid arthritis (RA) and may also an impediment to optimal DMARD and biologic responses.  A new study has shown that after 1 year, obese RA patients undergoing bariatric surgery with weight loss had significantly lower disease activity.

ACR Releases Reproductive Health Guidelines for Rheumatic Diseases

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Today, the American College of Rheumatology (ACR) published the 2020 Guideline for the Management of Reproductive Health in Rheumatic and Musculoskeletal Diseases.