TIF1-Ab in Dermatomyositis Linked to Higher Cancer Risk
Several epidemiological studies have reported that a diagnosis of DM or PM may be associated with increased cancer risk. The association appears stronger for DM than PM.
News
H2H: Ixekizumab vs. Adalimumab in Psoriatic Arthritis
Lilly has issued an advanced press release on its SPIRIT-H2H trial, wherein ixekizumab (Taltz) was shown to be more effective than than adalimumab (Humira) in a 24 week psoriatic arthritis study.
Rising Physician Exclusion from Medicare and Medicaid
JAMA Network Open has published that an increasing number of physicians are being excluded from Medicare and other forms of public insurance.
Cryotherapy Never FDA Approved
Another injury related to whole body cryotherapy (WBC) has been reported by practitioners in Philadelphia, serving as yet another warning of WBC's potential to cause serious adverse effects.
RheumNow Podcast – Vasculitis and Strange Bedfellows (12.14.18)
Dr. Jack Cush reviews the news from the past week on RheumNow.com.
CDC Top 15 Most Common Opioid Overdose Drugs
The Dec. 12 issue of the National Vital Statistics Reports from the U.S. Centers for Disease Control and Prevention reports that the most commonly abused drugs causing drug overdose deaths (between 2011-2016) include fentanyl, heroin, oxycodone, and cocaine.
Psoriatic Arthritis Does Not Add to Pregnancy Problems
When psoriatic arthritis (PsA) patients become pregnant, they do not have more infertility or adverse pregnancy outcomes compared to healthy controls.
No End in Sight for the Shingrix Vaccine Shortage
There is a national shortage of a new shingles vaccine, Shingrix, which is a problem for those who want to start the vaccine and those seeking to receive their second and final injection.
IL-23 Outduels IL-17 Inhibition in Psoriasis
Johnson & Johnson has announced the preliminary results of its phase 3 ECLIPSE study; a head-to-head trial wherein guselkumab (Tremfya; an IL-23 inhibitor) was compared to secukinumab (Cosentyx; an IL-17 inhibitor) in adults with moderate to severe plaque psoriasis.
CV Risks Similar in Systemic Sclerosis and Rheumatoid Arthritis
Interactions between disease-related inflammatory processes and the development of several morbidities have been well-studied in RA, particularly heart disease. This is not the case for the often-lethal SSc (estimated standardized mortality ratio between 2.5 and 4.0).
Genetic Diagnosis for Previously Undiagnosed Disorders
The NEJM has reported the NIH's Undiagnosed Diseases Network (UDN) study results of genetically identifying new diseases from prospectively followed persons with undiagnosed disorders. The UDN was formed in 2014 as a network of seven clinical sites, two sequencing cores, a coordinating center, central biorepository, a metabolomics core, and a model organisms screening center. It was established to apply a multidisciplinary model in the evaluation of the most challenging cases and to identify the biologic characteristics of newly discovered diseases.
SLE and Risk of Malignancy
The risk for cancer in systemic lupus erythematosus (SLE) patients has been inconsistently studied. A new metanalysis shows that SLE has an increased risk for 16 specific cancers and decreased risk for prostate cancer and cutaneous melanoma.
Patients Don't Always Tell the Truth
Sometimes patients withhold information from their doctors, and a new study suggests that as much as 60 - 80% of patients consciously omit information to their doctors, despite knowing this may bear on their health and well-being.
RheumNow Podcast – Can RA Be Prevented (12.7.18)
Dr. Jack Cush reviews the news and new journal articles from the past week on RheumNow.com:
Chronic Kidney Disease Increasing in the U.S.A.
JAMA has published the Global Burden of Disease (GBD) study showing that that, from 2002 to 2016, the US burden of chronic kidney disease (CKD) increased, with some states exhibiting more than twice the burden as others.
