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HLA-B*5801 Testing Needed in Asians and Blacks with Gout

Choi and colleagues analyzed US hospitalizations (2009–2013) to assess the frequency and racial distribution of patients hospitalized with Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) related to the use of urate-lowering (ULT) therapy (predominantly allopurinol).

Does Psoriasis Increase Risk of Abdominal Aneurysm?

Danish researchers studied a cohort of 59,423 mild psoriasis and 11,566 severe psoriasis patients over a 14 year period, and found 240 and 50 cases of abdominal aortic aneurysms (AAA), repectively. (Citation source http://buff.ly/1YxGpDA)

CV Events Strike Early in Lupus

Patients with systemic lupus erythematosus are at risk of cardiovascular events early in the course of disease -- and even before their lupus is diagnosed, an international study found.

RheumNow Week in Review - 15 April 2016

Video recap of highlights from this week at RheumNow.com.

Surgical Management of Spinal Stenosis - To Fuse or Not To Fuse?

Three articles (2 studies, 1 commentary) in this week's issue of NEJM tackle the issue of whether fusion adds anything to long-term outcomes in those undergoing decompression for lumbar spinal fusion.

Biosimilar Reports - April 2016

Major advances in biosimilars have occurred in the last three months, beginning with the FDA Arthritis Advisory Committee voting 21-3 to approve Celltrion’s Inflectra (CT-P13) and ending with the recent approval of Inflectra (generically referred to as infliximab dyyb).

Lupus Patients Genomically Stratified to Explain Treatment Responses

Systemic lupus is a clinically heterogeneous disorder, unified by requisite clinical features and exuberant humoral response to unknown triggers.  While the diagnosis is easy, the disease course and management can be complicated and challenging.  

Could Rheumatoid Synovium Be a Nursery for ACPA Producing Plasma Cells ?

One of the hallmarks of aggressive rheumatoid arthritis (RA) is presence of antibodies against citrullinated protein antigens (ACPA).

Population-Based TB Risk and Prevention with RA and Biologics

In a retrospective cohort comparison study, 42,180 rheumatoid arthritis (RA) patients were compared 1:4 with 168,000 normal controls to examine the incidence of new tuberculosis in Taiwan. The RA population included those receiving csDMARDs (36,162), etanercept (3,577), adalimumab (1,67

A Rocky Start for Biosimilar Inflectra?

This week, when the FDA approved the biosimilar drug Inflectra as an alternative to infliximab (Remicade), it was only the second biosimilar to be granted approval in the United States, and was the fi

Methotrexate Toxicity Quantified

Methotrexate (MTX) is a highly favored drug in rheumatology.  Yet it has numerous nuisance side effects that may limit its use or patient acceptance.

March 2016 Top Social Media News

In March 2016, RheumNow published 82 social media “tweets” regarding news, research and teaching points that impact the rheumatology community. These feeds had a reach (impressions) of 86,400 with, 76 mentions, and over 2700 visits to learn on RheumNow.com.

RheumNow Week in Review - 8 April 2016

Dr. Jack Cush reviews the rheumatology highlights from the news, media, and journals from this past week:

Altering the Microbiome May Benefit Lupus Patients

 
Previous research has suggested a potential role for gut dysbiosis and alterations Th17 and regulatory T (Treg), along with IL-17, IL-22, and IL-23, in the pathogenesis of SLE. 

Lopez and colleagues from Spain have studied the gut microbiome of l

Statin Side Effects Are For Real

The GAUSS-3 trial, recently published in JAMA, examined cholesterol-lowering interventions in patients with a high LDL (>120 mg/dl) and a history of statin intolerance to 2 or more statins. 

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