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Biosimilars Reviewed by Expert Panel

As the number of biosimilars in development keeps on growing, reaching nearly 700 products to date, demand for data from randomized controlled trials (RCTs) and an understanding of these new biologics  is peaking the interest of many. 

Tocilizumab Induces and Maintains Remission in Giant Cell Arteritis

Lancet has reported the results of a randomized, double-blind, placebo-controlled trial of tocilizumab in patients with new-onset giant cell arteritis (GCA).

"Lost to Follow-up" Patients are Common in Rheumatology

The frequency of not returning (lost to follow-up) (LTFU) in patients with rheumatic diseases is high. Associated demographic factors included older age in RA, female gender in SLE and Ps/PsA, and younger age in Ps/PsA, with various reasons for being LTFU.

Drugs that May Induce Raynaud's

A systematic review by Khouri examined the extent drugs are capable of inducing Raynaud's phenomenon (RP).

Ixekizumab Superior to Etanercept in Psoriasis

The UNCOVER-2 and UNCOVER-3 trials were presented at the American Academy of Dermatology (AAD) Annual Meeting taking this week in Washington, D.C.

Vitamin D has No Effect on Knee Osteoarthritis

Vitamin D supplementation for individuals with knee osteoarthritis and low 25-hydroxyvitamin D levels did not reduce knee pain or slow cartilage loss, according to a study appearing in the March 8 issue of JAMA.
 

Novel Protein as a Potential Autoantigen in JIA

Juvenile idiopathic arthritis (JIA) is clearly not related to rheumatoid arthritis and until recently has no identifiabile autoantigen linked to JIA.

Pregnancies are Adversely Affected Even Before the Diagnosis of Lupus

Arkema and colleagues assessed maternal and fetal outcomes in patients with SLE, pre-clinical (prior to onset) SLE and prevalent maternal SLE during pregnancy compared with the general population.

The Week in Review - 4 March 2016

Highlights from this week on RheumNow:

Intraarticular Steroids Before Joint Surgery Increase Infection Risk

Hip and knee intraarticular injection of corticosteroids are frequently prescribed to alleviate pain or inflammation in patients with osteoarthritis and rheumatoid arthritis, especially in the period leading up to scheduled arthroplasty.

AAOS Guidelines on Carpal Tunnel Diagnosis

Three million Americans are diagnosed with carpal tunnel syndrome each year. 

Muscle Weakness Predicts Disability in Scleroderma

Muscle weakness was independently associated with disability in patients with scleroderma, and as muscle weakness worsened, disability also increased, according to findings from a retrospective, nested, case control study.

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