4 April 2025

An Epidural Letdown (4.4.2025)

Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com.

An Epidural Letdown (4.4.2025)

Systematic review 21 studies showed potential of RTX with IVIg in autoimmune Dz - 10 studies on pemphigus (85 pts) - al

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Systematic review 21 studies showed potential of RTX with IVIg in autoimmune Dz - 10 studies on pemphigus (85 pts) - all Positive outcomes except 1 paraneoplastic pemphigus. Infections (eg, P. jirovecii pneumonia) seen in 3. 11 studies (24 pts) Rx'd neuropathies, CND lupus& https://t.co/o0RRUBIqmS

Commemorating the 15th Anniversary of the Biologics Price Competition and Innovation Act (by Dr. Sara Yim, FDA) - BPCIA

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Commemorating the 15th Anniversary of the Biologics Price Competition and Innovation Act (by Dr. Sara Yim, FDA) - BPCIA enacted March 23, 2010 - created pathway for biosimilar approvals - Now ~70 FDA approved biosimilars; 18 in 2024 https://t.co/dhST5vAJyT https://t.co/BWefr7k9hh

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Expert discusses the Biologics Price Competition and Innovation Act https://buff.ly/XDWuMWK

South Korean nationwide cohort study of 888,909 newly diagnosed #OA pts compared NSAID safety. Nephrotoxicity varied: lo

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RheumNow

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South Korean nationwide cohort study of 888,909 newly diagnosed #OA pts compared NSAID safety. Nephrotoxicity varied: lowest w/ meloxicam (aHR=1.22 [0.68–2.19]), higher w/ loxoprofen (aHR=3.9 [1.56–10.00]), celecoxib (aHR=2.4 [1.68–3.53]), naproxen (aHR=4.7 [2.16–10.24]) https://t.co/wfWIdoRQGO

3 April 2025

Vamorolone: a New Steroid on the Horizon?

Vamorolone is a potentially new alternative to traditional glucocorticoids for use in inflammatory diseases. It is a dissociated steroidal compound with reduced side effects, and in an animal model of inflammation has shown effective antiinflammatory properties and reduced systemic effects, as compared with prednisolone. But will this hold true in humans and at higher doses?

3 April 2025

Steroids, Prophylaxis and Pneumocystis Pneumonia

A case-control study has shown that glucocorticoids and tapering glucocorticoids are risk factors for the development of Pneumocystis jirovecii pneumonia (PJP). The authors provide guidance on the optimal timing for prophylaxis use and withdrawal.

Congrates to Arthritis Research & Therapy on their 25th anniversay - 25 years of research and therapy in arthritis.

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Congrates to Arthritis Research & Therapy on their 25th anniversay - 25 years of research and therapy in arthritis. Started 25 yrs ago by Drs. Peter Lipsky and Ravinder Maini https://t.co/4GFj9qktzr https://t.co/bUz0Ms0y6M

Links

25 years of research and therapy in arthritis - Arthritis Research & Therapy https://buff.ly/oQMbh2F

An estimated 118,000 people throughout the world have EGPA. Steroids & immunosuppressants have been the mainstay; bu

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RheumNow

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An estimated 118,000 people throughout the world have EGPA. Steroids & immunosuppressants have been the mainstay; but for managing EGPA. Mepolizumab (2015) & Benralizumab (2024) are FDA approved for EGPA. The latter (Fasenra) approval based on the MANDARA trial https://t.co/84W4sOig9d

To promote broader avail. of biosimilars in EU, EMA has proposed a new path for new biosimilars, omitting comparative cl

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To promote broader avail. of biosimilars in EU, EMA has proposed a new path for new biosimilars, omitting comparative clinical trial data, as long as biosimilar shows structural & functional comparability, w/ pharmacokinetic & interaction data (relative to reference product) https://t.co/24aTCuDwdO

Topics

An Epidural Letdown (4.4.2025)

An Epidural Letdown (4.4.2025)

Systematic review 21 studies showed potential of RTX with IVIg in autoimmune Dz - 10 studies on pemphigus (85 pts) - al

Commemorating the 15th Anniversary of the Biologics Price Competition and Innovation Act (by Dr. Sara Yim, FDA) - BPCIA

South Korean nationwide cohort study of 888,909 newly diagnosed #OA pts compared NSAID safety. Nephrotoxicity varied: lo

Congrates to Arthritis Research & Therapy on their 25th anniversay - 25 years of research and therapy in arthritis.

An estimated 118,000 people throughout the world have EGPA. Steroids & immunosuppressants have been the mainstay; bu

To promote broader avail. of biosimilars in EU, EMA has proposed a new path for new biosimilars, omitting comparative cl

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