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Osteoarthritis

The path to new technologies in rheumatology must be beset with caution

As we have incorporated technology into our workflows, and consequently saved lives and suffering, we have balanced our excitement about progress with proof that incremental advances can truly deliver benefit. it is easy to let promise carry our caution away - and while most of the time such

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IL-6 Immunotherapy for knee OA PPV-06 FTIH Phase 1 Is it safe? looks it, no serious AES, 6mo follow up Is it immunogenic? apparently so, IL-6 Ab & neutralizing Ab Does it work? will have to wait for Phase 2 Somehow bold knowing TCZ did not work in hand OA AbstLBA0011 #EULAR2024… https://t.co/pO0Dx3jl8E https://t.co/p1zYUtgFoM
Aurelie Najm @AurelieRheumo( View Tweet )
New reccs for knee/hip #OA w/2 overarching principles 1. Biopsychosocial approach 2.Individualized Rx w/shared decision making (includes education, diet/exercise, healthy weight, appropriate assistive device/footware, modify work factors, pain coping skills) #EULAR24 @rheumnow https://t.co/0LVLBMGO7L
TheDaoIndex @KDAO2011( View Tweet )
Thanks for these updates recommendations for hip/knee OA -- but, still not much has changed. #eular2034 https://t.co/NMwFWxwocF
Dr. John Cush @RheumNow( View Tweet )
DMOADs in #osteoarthritis at #EULAR2024: 1) Tonia Vincent: StepUp OA endotype SF proteomics —> endothelial to mesenchymal transition proteins. 2) Phil Conaghan: proregenerative (& degeneration slowing) therapies in pipeline. 3) @Larhumato: novel RCT designs & structure outcomes

Tuhina Neogi, MD, PhD @Tuhina_Neogi( View Tweet )

Mapping the knee #osteoarthritis joint-nerve interactome — presented by @AM_Malf at #EULAR2024. Anatomical and molecular neuroplasticity occurs during OA onset + progression in the joint and DRG. Cool imaging of nerves and their activity with lightsheet microscopy in mice https://t.co/cre6LEVhle
Tuhina Neogi, MD, PhD @Tuhina_Neogi( View Tweet )
Another option for Knee Oa management? Wearable transcutaneous nerve stimulation (W-TENS) reduces the need for surgery. #EULAR2024 @rheumnow abst#POS1072 https://t.co/flcfrCrY2X
Bella Mehta @bella_mehta( View Tweet )
Infrapatellar fat pad morphology- mainly volume on MRI associated progostication in knee #OA - structural changes! using OAI data #EULAR2024 abst#OP0292 @rheumnow

Bella Mehta @bella_mehta( View Tweet )

Some of these drugs dont seem to work in all of knee OA. I guess its really difficult to tease out different subtypes. Subgroup analysis from a Phase 3 intraarticular JTA-004 injection at #EULAR2024 abst#Op0305 @RheumNow https://t.co/jbkLYyl93e
Bella Mehta @bella_mehta( View Tweet )
40% women above 60yo have #osteoarthritis. 25% have hand OA #EULAR24 https://t.co/9ZaQYIYIxn
Vasco C Romao @romaovc( View Tweet )
Australian studyshows knee OA pts unconsciously believe that activity may be dangerous to their condition, despite medical advice telling them otherwise. 69% of people with knee pain had stronger implicit (unconscious) beliefs that exercise was dangerous https://t.co/iytfpcGvD8 https://t.co/N183ffYfPP
Dr. John Cush @RheumNow( View Tweet )
2023 EULAR classification criteria for hand osteoarthritis A EULAR consensus group has established classification criteria for overall hand osteoarthritis (OA) and its subtypes (interphalangeal OA and thumb base OA). https://t.co/wIgjYB2rXF https://t.co/TjSILyC4IT https://t.co/3x6YtXW81u
Dr. John Cush @RheumNow( View Tweet )

2023 EULAR classification criteria for hand osteoarthritis

A EULAR consensus group has established classification criteria for overall hand osteoarthritis (OA) and its subtypes (interphalangeal OA and thumb base OA).

The criteria require two mandatory criteria to be met:

  1. must have

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Metformin Lowers Gout Risk in Pre-Diabetes

A large, propensity score-matched cohort study shows that metformin use in patients with pre-diabetes significantly lowers the risk of future gout. 

Metformin is widely used for diabetes and pre-diabetes. Importantly, its use has been linked with a

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ACR Website to Support Primary Care Practitioners

ACR

The American College of Rheumatology recently launched Rheumatology for Primary Care, a new resource for primary care physicians (PCP) and advanced practice providers (APP) offering them expanded support and

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The ability to predict hip fractures just went to a new level https://t.co/k9cAPIJigd A proteomic risk score was found to be strongly predictive of incident hip fractures in multiple independent populations @NatureAging https://t.co/WZemPZqsev
Eric Topol @EricTopol( View Tweet )
Australian multicenter KARAOKE RCT of 262 adults w/ Knee OA (w/ MRI effusion/synovitis) Rx w/ placebo vs , 2 g/d of krill oil showed no significant benefit in pain VAS score, −19.9 [krill oil] vs −20.2 [placebo]. https://t.co/aeNcVM0p8J https://t.co/2PR0PG6eWj
Dr. John Cush @RheumNow( View Tweet )
Australian multicenter KARAOKE RCT of 262 adults w/ Knee OA (w/ MRI effusion/synovitis) Rx w/ placebo vs , 2 g/d of krill oil showed no significant benefit in pain VAS score, −19.9 [krill oil] vs −20.2 [placebo]. https://t.co/8QSZyzIVh9 https://t.co/WbSb2gcmHb
Dr. John Cush @RheumNow( View Tweet )
Alot of murky "research" on Platelet-rich plasma (PRP). This RCT of120 pts having anterior cruciate ligament reconstruction (half randomized to PRP) shows no PRP benefit, no significant improvement of knee symptoms & function post ACLR https://t.co/AwkCAq1QFb https://t.co/YP0hJd7soc
Dr. John Cush @RheumNow( View Tweet )

"Don't You Know Who I am?" (5.17.2024)

Dr. Jack Cush reviews the news and journal reports from the past 2 weeks. This week's question: can we prevent gout, ILD or psoriasis?

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Retrospective, cross-sectional study from the Osteoarthritis Initiative (OAI), 2607 pts (age 64yrs; BMI 28.5). After 48 mos regular bicycling yielded signif less knee pain (HR 0.83), Xray OA (0.91) & Sxs OA (0.79), Encourage Bicycling! https://t.co/ktocvwujwt https://t.co/DOfE1BFRJh
Dr. John Cush @RheumNow( View Tweet )
Lower Limb Muscle Mass Influences Osteoarthritis Risk The Rotterdam study shows that weight-bearing recreational physical activity caused more incident knee osteoarthritis (KOA), but mainly when there was low muscle mass. https://t.co/N6JnJJgXgY https://t.co/hL7fK0DPWJ
Dr. John Cush @RheumNow( View Tweet )
Biomarker Predictors of Osteoarthritis Science Advances has reported that Duke University researchers have validated a biomarkers of osteoarthritis that may be identified 2 years before the appearance of radiographic OA. S https://t.co/z5Tg9pAgqO https://t.co/ltY4rEg9p3 https://t.co/AjCKaUW59X
Dr. John Cush @RheumNow( View Tweet )

Featured BSR Abstracts (5.2.2024)

Dr. Jack Cush muses on the news, journal reports, FDA announcements and the 2024 BSR abstracts just released.

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Biomarker Predictors of Osteoarthritis Science Advances has reported that Duke University researchers have validated a biomarkers of osteoarthritis that may be identified 2 years before the appearance of radiographic OA. S https://t.co/T9XQ3x9yc2 https://t.co/HdwbXR1nDX
Dr. John Cush @RheumNow( View Tweet )