Osteoarthritis

Open label trial compared arthroscopic repair to PT in 100 young pts w/ traumatic, MRI proven meniscal tear without knee OA. Outcomes at 24 months - both groups improvved and were not different between groups https://t.co/rbrUAWuKRa https://t.co/OaNTssAvCG

How much does diet and exercise help in knee osteoarthritis? Pragmatic RCT (WE-CAN), n=823 a diet & exercise intervention program led to: - 10kg weight loss - some significant pain improvements We need to fund diet & exercise programs for OA patients! ABST1675 #ACR22 @RheumNow https://t.co/Ctm8ZoRF3o

WE-CAN pragmatic RCT on community-dwelling ♂️&♀️ >/=50y w/ knee #osteoarthritis & obesity: 💠Diet + exercise = significant weight ⬇️and ☑️WOMAC pain score, WOMAC function, 6min walk distance & SF-36 HRQoL 🍽️+🚶‍♀️in OA? = Yes we can! #ACR22 @RheumNow @rheumarhyme https://t.co/Ty2boH52HC

Ab1675 #ACR22 WE-CAN - Knee OA 823 randomized pts, 18 mo: Intensive Diet & Exercise (D+E) Primary endpt: WOMAC pain - 32% reduct in pain in D+E, vs 24% (PBO) 20% more likely: clinically meaningful improve Improved BMI, 6MW, HRQoL, activity Pain Rx, depression: no change @RheumNow https://t.co/Su2g4Z38FV

Does diet & exercise work for knee pain in #osteoarthritis? Pragmatic trial in 3 community sites. 823 RCT, 80% completed -control was education &meetings vs diet&exercise;more intense. 101kg, 77% F, age 65. Diff modest-favoured diet & exercise-works a bit #ACR22 @RheumNow #1675 https://t.co/akjEjVprJl

Plenary session III: Intensive diet and exercise program in overweight/obese pts with knee OA showed significant reduction in weight, pain and function, greater walk distance and quality of life. Abs#1675 @RheumNow #ACR22 https://t.co/vstfJahLQV

Messier et al. WE-CAN pragmatic trial of diet and exercise (vs attention control) in knee OA with high BMI. Significant improvement in pain, walk distance, SF-36 with corresponding reduction in body weight @RheumNow #ACR22 Abstr#1675 https://t.co/uSSzx4u2sp https://t.co/upnIVecRjv

In overweight and obese patients with knee OA, 18-months of diet and exercise delivered in community settings significantly reduced WOMAC knee pain (-0.6) compared to an attention control group. Messier S Abs#1675 https://t.co/GvPCGz0NMN #ACR22 @RheumNow https://t.co/yWAwGwunzT

Promising data on denosumab in erosive OA Phase 2 study - less erosive progression, more symptom improvement Abs# L05 @RheumNow #ACR22 https://t.co/9Fg3r02ZQG

Wittoek et al. 48-week RCT of Denosumab in erosive hand OA. Prevents structural progression! @RheumNow #ACR22 Abstr#L05 #ACRbest https://t.co/CI6VBERSmn https://t.co/OszJkGeJF7

L05 #ACR22 High-dose Denosumab in Erosive Hand OA 48Wk, Double-blind PBO Phase 2 100 patients GUSS change higher in DEN v PBO at w24, incr at w48 New erosions lower in DEN w48 (2% v 7%, OR 0.23, p<0.001) Open label extension w improvement to baseline @RheumNow https://t.co/X6MF9q2bKj

Walrabenstein et al. RCT of 16-week triple intervention - plant-based diet, exercise, stress management - vs usual care in OA. It works, but we don't know which component, or if Hawthorn effect @RheumNow #ACR22 Abstr#1644 https://t.co/p74Ptd8bZ2 https://t.co/EOg7RxRmO7

Utamawatin et al. DB-RCT of Triamcinolone 10mg vs 40mg for knee OA. No difference! Wonder if 10mg would be better than saline? @RheumNow #ACR22 Abstr#1890 https://t.co/vcKze7mSf4 https://t.co/ErEkmUN0Wp

Maksymowych et al. RCT ofAdalimumab for knee OA!? it doesn't work. @RheumNow #ACR22 Abstr#1891 https://t.co/pfPVJ9A1Ex https://t.co/X7sLEaqGvT

Yazici et al. RCT of IA Lorecivivint for moderate/severe knee OA. CLK/DYRK inhibitor. No effect seen. @RheumNow #ACR22 Abstr#1899 https://t.co/XGQrMmNnSR https://t.co/rSJrT6Hms6

Bihlet et al. Anti-histamines may reduce structural progression of knee OA. Post-hoc analysis of 2 trials @RheumNow #ACR22 Abstr#1893 https://t.co/RrrelHDz75 https://t.co/Sf7RpjjAaN

Shanahan et al. RCT of Genicular nerve block for knee OA. It works but temporary, with loss of effect by week 12. @RheumNow #ACR22 Abstr#1892 https://t.co/VySjBGrVeR https://t.co/JNKQeOVB6z

QD Clinic - How to Treat Erosive OA (abstract #L05) 61yoWM with bilateral pain/swelling in DIPs. Labs normal, seronegative and Xrays shows evidence of DIP erosive OA. But what works in EOA? #ACR22 https://t.co/tbIoTg6kxA https://t.co/YcW7TON0En

What's the role of MRI in #osteoarthritis? #ACR22 @RheumNow #acrreview https://t.co/uZEzUSLo88

When referring to radiographs in #osteoarthritis, it can be better described as early, advanced or end-stage as it only shows the extent of joint damage accrued over time, not telling us much on the severity of disease - Dr. Scanzello #ACR22 @RheumNow https://t.co/m7Vdmu6KM6

#osteoarthritis pain is complex! @rheumarhyme 🔸pain sensitization - ⬆️responsiveness of peripheral nociceptors 🔸more severe pain on mov't 🔸assoc . w/ synovitis #ACR22 @RheumNow #acrreview https://t.co/PbQOv6386W