Osteoarthritis

Intraarticular IL-1Ra Gene Therapy in Knee Osteoarthritis In a dose-escalation trial in nine participants, they observed that a single intra-articular injection of the gene product led to an increase in IL-1Ra in the synovial fluid that remained elevated for up to a year. There https://t.co/YDuUg44ebu
Dr. John Cush @RheumNow( View Tweet )
Presenteeism and absenteeism in RA aren’t just about joints. In this UK study, comorbid anxiety, depression, and OA drove lost productivity. Treating RA is not enough —holistic management matters. POS0403 @RheumNow #EULAR2025

Jiha Lee @JihaRheum( View Tweet )

The relation between RA, comorbidities and presenteism NRAS survey 891 RA pts 75% had at least one comorbidity Absenteeism more likely if One OR = 1.68 or Two OR = 2.26 comorbid conditions In particular Anxiety OR = 2.39 Depression OR = 1.75 Osteoarthritis OR = 1.85 Back

Aurelie Najm @AurelieRheumo( View Tweet )

What do we do when we see Rx signed of CPPD in RA pts? Do these pts have different trajectory? Rx Retro study 388 patients RA 18% at least one sign CPPD ns diff between seeonegative and seropositive pts RA+CPPD group was -older -higher comorbidity score -more likely to be https://t.co/DaW5DZoDzF

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Aurelie Najm @AurelieRheumo( View Tweet )
Targets for OA pain pharmacotherapies some by the wayside: - NGF - TrkA but some very much in play and exciting: - neurotrophin-3 - TRPV1 - Nav1.7, 1.8 Fiona Watt #EULAR2025 @RheumNow https://t.co/DXDKNnVRRo

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David Liew @drdavidliew( View Tweet )
LEVI-04 (neutrophin-3 inhibitor presented as #ACR24 late-breaker in knee OA) more good efficacy data, no rapidly progressive OA safety signal. For us clinicians: impressive impact size, esp relative to alternatives. Finally, something that works?? #EULAR2025 OP0374 @RheumNow https://t.co/iVdlwyaqrv

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David Liew @drdavidliew( View Tweet )
Intraarticular IL-1Ra Gene Therapy in Knee Osteoarthritis In a dose-escalation trial in nine participants, they observed that a single intra-articular injection of the gene product led to an increase in IL-1Ra in the synovial fluid that remained elevated for up to a year. There https://t.co/qi0qHPd06j
Dr. John Cush @RheumNow( View Tweet )
🦵🏼💉LOSEIT study: liraglutide led to slight↑ in medial joint space width in knee OA vs placebo (0.22 vs 0.07 mm), but difference not statistically significant (p=0.17). More potent GLP-1RAs may be needed for greater improvement in structural knee OA @RheumNow #EULAR2025 #OP0223

Mrinalini Dey @DrMiniDey( View Tweet )

▶️Erosive hand OA 🔺Gull-wing erosion @ DIPJs ✅ 🔺Saw-tooth erosions @ PIPJs ✅ #OA #Osteoarthritis #EULAR2025 https://t.co/5Hh4Ki9P8V

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Dr Gurdeep S Dulay @gurdeep_dulay( View Tweet )
Pain & age predict outcomes in #osteoarthritis In a #cohort of 92 pts with #knee #OA Factors were studied for response Better ✅#NSAIDs or #acetaminophen v #opiates ✅Older ✅Lower #WOMAC PAIN & no sensitization 🤔help RCT inclusion #EULAR2025 @RheumNow POS0612 @eular_org https://t.co/9I2JN9sgUe

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Janet Pope @Janetbirdope( View Tweet )
Repurposing drugs to #osteoarthritis No jewel in the rough! Most drugs - MTX, colchicine, TNFi, IL1i, etc are NEGATIVE or yield mixed results from diff #RCTs Not sure this is the way forward for #OA drug discovery 💡 #EULAR2025 @RheumNow @eular_org Abst#POS565 https://t.co/A6SdXtOo7v

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Janet Pope @Janetbirdope( View Tweet )
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Intraarticular IL-1Ra Gene Therapy in Knee Osteoarthritis

Jack Cush, MD

De la Vega et al. have published in Science Translational Medicine the efficacy of an IL-1Ra gene therapy in adults with knee osteoarthritis (OA).

In a dose-escalation trial in nine participants, they observed that a single intra-articular injection of the gene

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MTX Fails Knee OA (6.6.2025) Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow. https://t.co/4FapDWtTIf https://t.co/lYoTXX9IEb

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Dr. John Cush @RheumNow( View Tweet )
Methotrexate Fails in Knee Osteoarthritis We'll be blunt: methotrexate flopped in a randomized placebo-controlled trial among patients with osteoarthritis (OA) of the knee. https://t.co/Y9elFXTkhN https://t.co/rs8wP7A1bv

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Dr. John Cush @RheumNow( View Tweet )
Methotrexate Fails in Knee Osteoarthritis We'll be blunt: methotrexate flopped in a randomized placebo-controlled trial among patients with osteoarthritis (OA) of the knee. https://t.co/Y9elFXTkhN https://t.co/oqDDVPGbh7

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Dr. John Cush @RheumNow( View Tweet )
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MTX Fails Knee OA (6.6.2025)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com

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knee.oa_.jpg (keep)

Methotrexate Fails in Knee Osteoarthritis

MedPage Today

We'll be blunt: methotrexate flopped in a randomized placebo-controlled trial among patients with osteoarthritis (OA) of the knee.

Contrary to results from a previous trial in hand OA, the old-line disease-modifying anti-rheumatic drug (DMARD) failed to bring any improvement relative to placebo

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Turkish study of 1263 primary care referrals to rheumatology found 35.7% with inflammatory rheumatic Dz (IRD), 17.7% osteoarthritis, and 11.2% regional pain syndromes. Another German study showed low risk of IRD if CRP <5 https://t.co/v5qYb7c7jP https://t.co/iq4NfcC3cH https://t.co/6lkTMSBUqc

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Dr. John Cush @RheumNow( View Tweet )
Periprosthetic femoral Fx (PPFF): metanalysis of 36 studies found PPFF risk factors: Uncemented stems (OR 3.36), major teaching hosp (2.0), female (1.6), obesity (1.4), Hi comorbidity(1.4), RA (1.89), (1.67), revised THR (2.6). OA = protective (0.51) https://t.co/y2BpH8LUb6 https://t.co/EjX6R9QTK3

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Dr. John Cush @RheumNow( View Tweet )
Risk Factors for Knee Osteoarthritis New research from the University of Sydney reveals that obesity, having a knee injury and occupational risks such as shift work and lifting heavy loads are primary causes of knee osteoarthritis. https://t.co/Kc686Zc8Xa https://t.co/PtyLU6jBkp

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Dr. John Cush @RheumNow( View Tweet )
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Vitamin D Headlines (5.9.2025)

Jack Cush, MD

Dr. Jack Cush reviews the news, journal reports and lupus highlights from the past week on RheumNow.com. Triple positivity, the gut and CRPS, and hope for better outcomes with Vitamin D therapy. 

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Risk Factors for Knee Osteoarthritis

EurekAlert!

New research from the University of Sydney reveals that obesity, having a knee injury and occupational risks such as shift work and lifting heavy loads are primary causes of knee osteoarthritis.

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Finish Birth Cohort followed since 1986, who were asymptomatic, found abnormal MRI knee findings, esp cartilage defects in the patellofemoral (56%) & tibiofemoral joints (25%) joints. Small/doubtful patellofemoral (52%) & tibiofemoral (17%) osteophytes seen. Most w/ High BMI. https://t.co/nQKREE4XfU
Dr. John Cush @RheumNow( View Tweet )
Finish Birth Cohort followed since 1986, who were asymptomatic, found abnormal MRI knee findings, esp cartilage defects in the patellofemoral (56%) & tibiofemoral joints (25%) joints. Small/doubtful patellofemoral (52%) & tibiofemoral (17%) osteophytes seen. Most w/ High BMI. https://t.co/LHqmRHM5wF
Dr. John Cush @RheumNow( View Tweet )
Metformin Effective in Osteoarthritis The diabetes drug metformin provided overweight/obese patients with osteoarthritis (OA) of the knee with significantly greater pain relief than did placebo in a small randomized trial, researchers said. https://t.co/7krvFFfRFC https://t.co/g1UyNjazUv

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Dr. John Cush @RheumNow( View Tweet )

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